The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2
The role of endothelial copper transporter ATP7A in vascular function and angiogenesis remains largely unexplored. Here the authors show that ATP7A promotes VEGFR2 signaling and angiogenesis by limiting autophagy-mediated degradation of VEGFR2, which enhances reparative neovascularization.
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Nature Portfolio
2021
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oai:doaj.org-article:7349411310e2453bb951aceb39ac71222021-12-02T15:00:50ZThe P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR210.1038/s41467-021-23408-12041-1723https://doaj.org/article/7349411310e2453bb951aceb39ac71222021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23408-1https://doaj.org/toc/2041-1723The role of endothelial copper transporter ATP7A in vascular function and angiogenesis remains largely unexplored. Here the authors show that ATP7A promotes VEGFR2 signaling and angiogenesis by limiting autophagy-mediated degradation of VEGFR2, which enhances reparative neovascularization.Dipankar AshVaradarajan SudhaharSeock-Won YounMustafa Nazir OkurArchita DasJohn P. O’BryanMaggie McMenaminYali HouJack H. KaplanTohru FukaiMasuko Ushio-FukaiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Dipankar Ash Varadarajan Sudhahar Seock-Won Youn Mustafa Nazir Okur Archita Das John P. O’Bryan Maggie McMenamin Yali Hou Jack H. Kaplan Tohru Fukai Masuko Ushio-Fukai The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2 |
| description |
The role of endothelial copper transporter ATP7A in vascular function and angiogenesis remains largely unexplored. Here the authors show that ATP7A promotes VEGFR2 signaling and angiogenesis by limiting autophagy-mediated degradation of VEGFR2, which enhances reparative neovascularization. |
| format |
article |
| author |
Dipankar Ash Varadarajan Sudhahar Seock-Won Youn Mustafa Nazir Okur Archita Das John P. O’Bryan Maggie McMenamin Yali Hou Jack H. Kaplan Tohru Fukai Masuko Ushio-Fukai |
| author_facet |
Dipankar Ash Varadarajan Sudhahar Seock-Won Youn Mustafa Nazir Okur Archita Das John P. O’Bryan Maggie McMenamin Yali Hou Jack H. Kaplan Tohru Fukai Masuko Ushio-Fukai |
| author_sort |
Dipankar Ash |
| title |
The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2 |
| title_short |
The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2 |
| title_full |
The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2 |
| title_fullStr |
The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2 |
| title_full_unstemmed |
The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2 |
| title_sort |
p-type atpase transporter atp7a promotes angiogenesis by limiting autophagic degradation of vegfr2 |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/7349411310e2453bb951aceb39ac7122 |
| work_keys_str_mv |
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