Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance

Centromeres are centrochromatin domains with CENP-A and H3 nucleosomes carrying transcription-associated modifications. Here the authors target synthetic modules to the centromeres to show that transcription plus histone modifications are required for CENP-A assembly and centrochromatin maintenance.

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Autores principales:	Oscar Molina, Giulia Vargiu, Maria Alba Abad, Alisa Zhiteneva, A. Arockia Jeyaprakash, Hiroshi Masumoto, Natalay Kouprina, Vladimir Larionov, William C. Earnshaw
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7355b73cb5fc45f4a8cb124130f7a9aa
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spelling	oai:doaj.org-article:7355b73cb5fc45f4a8cb124130f7a9aa2021-12-02T17:32:54ZEpigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance10.1038/ncomms133342041-1723https://doaj.org/article/7355b73cb5fc45f4a8cb124130f7a9aa2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13334https://doaj.org/toc/2041-1723Centromeres are centrochromatin domains with CENP-A and H3 nucleosomes carrying transcription-associated modifications. Here the authors target synthetic modules to the centromeres to show that transcription plus histone modifications are required for CENP-A assembly and centrochromatin maintenance.Oscar MolinaGiulia VargiuMaria Alba AbadAlisa ZhitenevaA. Arockia JeyaprakashHiroshi MasumotoNatalay KouprinaVladimir LarionovWilliam C. EarnshawNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Oscar Molina Giulia Vargiu Maria Alba Abad Alisa Zhiteneva A. Arockia Jeyaprakash Hiroshi Masumoto Natalay Kouprina Vladimir Larionov William C. Earnshaw Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance
description	Centromeres are centrochromatin domains with CENP-A and H3 nucleosomes carrying transcription-associated modifications. Here the authors target synthetic modules to the centromeres to show that transcription plus histone modifications are required for CENP-A assembly and centrochromatin maintenance.
format	article
author	Oscar Molina Giulia Vargiu Maria Alba Abad Alisa Zhiteneva A. Arockia Jeyaprakash Hiroshi Masumoto Natalay Kouprina Vladimir Larionov William C. Earnshaw
author_facet	Oscar Molina Giulia Vargiu Maria Alba Abad Alisa Zhiteneva A. Arockia Jeyaprakash Hiroshi Masumoto Natalay Kouprina Vladimir Larionov William C. Earnshaw
author_sort	Oscar Molina
title	Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance
title_short	Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance
title_full	Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance
title_fullStr	Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance
title_full_unstemmed	Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance
title_sort	epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7355b73cb5fc45f4a8cb124130f7a9aa
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Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance

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