Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance

Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance

Centromeres are centrochromatin domains with CENP-A and H3 nucleosomes carrying transcription-associated modifications. Here the authors target synthetic modules to the centromeres to show that transcription plus histone modifications are required for CENP-A assembly and centrochromatin maintenance.

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Autores principales: Oscar Molina, Giulia Vargiu, Maria Alba Abad, Alisa Zhiteneva, A. Arockia Jeyaprakash, Hiroshi Masumoto, Natalay Kouprina, Vladimir Larionov, William C. Earnshaw
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/7355b73cb5fc45f4a8cb124130f7a9aa
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