Calcium ions promote formation of amyloid β-peptide (1-40) oligomers causally implicated in neuronal toxicity of Alzheimer's disease.

Calcium ions promote formation of amyloid β-peptide (1-40) oligomers causally implicated in neuronal toxicity of Alzheimer's disease.

Amyloid β-peptide (Aβ) is directly linked to Alzheimer's disease (AD). In its monomeric form, Aβ aggregates to produce fibrils and a range of oligomers, the latter being the most neurotoxic. Dysregulation of Ca(2+) homeostasis in aging brains and in neurodegenerative disorders plays a crucial r...

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Autores principales: Anna Itkin, Vincent Dupres, Yves F Dufrêne, Burkhard Bechinger, Jean-Marie Ruysschaert, Vincent Raussens
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Medicine
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Science
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Acceso en línea:https://doaj.org/article/73560769eb2b4e0fbcf4cfe302884870
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