The Parathyroid Hormone-Related Protein/Parathyroid Hormone 1 Receptor Axis in Adipose Tissue

Adipose tissue is an organ that shows great plasticity and is able to adapt to the conditions to which the body is subdued. It participates in the regulation of energetic homeostasis and has endocrine functions. Recent studies have shown how the parathyroid hormone-related protein (PTHrP)/Parathyroi...

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Autor principal:	Adriana Izquierdo-Lahuerta
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	PTHrP PTH1R PPARgamma adipose tissue Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/735d2f1e0b284df397ca67fb65cfde64
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spelling	oai:doaj.org-article:735d2f1e0b284df397ca67fb65cfde642021-11-25T16:52:00ZThe Parathyroid Hormone-Related Protein/Parathyroid Hormone 1 Receptor Axis in Adipose Tissue10.3390/biom111115702218-273Xhttps://doaj.org/article/735d2f1e0b284df397ca67fb65cfde642021-10-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1570https://doaj.org/toc/2218-273XAdipose tissue is an organ that shows great plasticity and is able to adapt to the conditions to which the body is subdued. It participates in the regulation of energetic homeostasis and has endocrine functions. Recent studies have shown how the parathyroid hormone-related protein (PTHrP)/Parathyroid Hormone Receptor 1 (PTH1R) axis participates in the regulation of adipogenesis, opposing the action of Peroxisome proliferator-activated receptor gamma (PPARγ). In addition to this, PTHrP is overexpressed in adipose tissue in situations of wear and tear of the body, favoring browning and lipolysis in this tissue. It is also overexpressed in adipose tissue in stressful situations but in the opposite direction, in obesity, metabolic syndrome, type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM). In conclusion, the PTHrP/PTH1R axis has a main role in adipose tissue, participating in its differentiation and remodeling. PTHrP might be used in obesity treatment and its complications for its ability to reprogram adipogenesis and adipose tissue expansion, WAT browning and for the improvement of the insulin sensitivity. In addition, PTHrP could even be used as a marker of placental status and maternal adaptations to prevent future metabolic problems in mothers and children, as well as in the treatment of bone-related diseases such as osteoporosis.Adriana Izquierdo-LahuertaMDPI AGarticlePTHrPPTH1RPPARgammaadipose tissueMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1570, p 1570 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PTHrP PTH1R PPARgamma adipose tissue Microbiology QR1-502
spellingShingle	PTHrP PTH1R PPARgamma adipose tissue Microbiology QR1-502 Adriana Izquierdo-Lahuerta The Parathyroid Hormone-Related Protein/Parathyroid Hormone 1 Receptor Axis in Adipose Tissue
description	Adipose tissue is an organ that shows great plasticity and is able to adapt to the conditions to which the body is subdued. It participates in the regulation of energetic homeostasis and has endocrine functions. Recent studies have shown how the parathyroid hormone-related protein (PTHrP)/Parathyroid Hormone Receptor 1 (PTH1R) axis participates in the regulation of adipogenesis, opposing the action of Peroxisome proliferator-activated receptor gamma (PPARγ). In addition to this, PTHrP is overexpressed in adipose tissue in situations of wear and tear of the body, favoring browning and lipolysis in this tissue. It is also overexpressed in adipose tissue in stressful situations but in the opposite direction, in obesity, metabolic syndrome, type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM). In conclusion, the PTHrP/PTH1R axis has a main role in adipose tissue, participating in its differentiation and remodeling. PTHrP might be used in obesity treatment and its complications for its ability to reprogram adipogenesis and adipose tissue expansion, WAT browning and for the improvement of the insulin sensitivity. In addition, PTHrP could even be used as a marker of placental status and maternal adaptations to prevent future metabolic problems in mothers and children, as well as in the treatment of bone-related diseases such as osteoporosis.
format	article
author	Adriana Izquierdo-Lahuerta
author_facet	Adriana Izquierdo-Lahuerta
author_sort	Adriana Izquierdo-Lahuerta
title	The Parathyroid Hormone-Related Protein/Parathyroid Hormone 1 Receptor Axis in Adipose Tissue
title_short	The Parathyroid Hormone-Related Protein/Parathyroid Hormone 1 Receptor Axis in Adipose Tissue
title_full	The Parathyroid Hormone-Related Protein/Parathyroid Hormone 1 Receptor Axis in Adipose Tissue
title_fullStr	The Parathyroid Hormone-Related Protein/Parathyroid Hormone 1 Receptor Axis in Adipose Tissue
title_full_unstemmed	The Parathyroid Hormone-Related Protein/Parathyroid Hormone 1 Receptor Axis in Adipose Tissue
title_sort	parathyroid hormone-related protein/parathyroid hormone 1 receptor axis in adipose tissue
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/735d2f1e0b284df397ca67fb65cfde64
work_keys_str_mv	AT adrianaizquierdolahuerta theparathyroidhormonerelatedproteinparathyroidhormone1receptoraxisinadiposetissue AT adrianaizquierdolahuerta parathyroidhormonerelatedproteinparathyroidhormone1receptoraxisinadiposetissue
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The Parathyroid Hormone-Related Protein/Parathyroid Hormone 1 Receptor Axis in Adipose Tissue

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