Integrated omics dissection of proteome dynamics during cardiac remodeling

Transcriptome data provide only a partial picture of disease states. Here, via integration of transcript-, protein abundance and protein turnover data for a mouse model of cardiac hypertrophy, the authors uncover additional disease gene signatures, and show that turnover data sheds unique light on p...

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Auteurs principaux:	Edward Lau, Quan Cao, Maggie P. Y. Lam, Jie Wang, Dominic C. M. Ng, Brian J. Bleakley, Jessica M. Lee, David A. Liem, Ding Wang, Henning Hermjakob, Peipei Ping
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/735fc1b56e0a42518ad0a64c538beba9
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spelling	oai:doaj.org-article:735fc1b56e0a42518ad0a64c538beba92021-12-02T15:33:41ZIntegrated omics dissection of proteome dynamics during cardiac remodeling10.1038/s41467-017-02467-32041-1723https://doaj.org/article/735fc1b56e0a42518ad0a64c538beba92018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02467-3https://doaj.org/toc/2041-1723Transcriptome data provide only a partial picture of disease states. Here, via integration of transcript-, protein abundance and protein turnover data for a mouse model of cardiac hypertrophy, the authors uncover additional disease gene signatures, and show that turnover data sheds unique light on posttranslational regulation.Edward LauQuan CaoMaggie P. Y. LamJie WangDominic C. M. NgBrian J. BleakleyJessica M. LeeDavid A. LiemDing WangHenning HermjakobPeipei PingNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Edward Lau Quan Cao Maggie P. Y. Lam Jie Wang Dominic C. M. Ng Brian J. Bleakley Jessica M. Lee David A. Liem Ding Wang Henning Hermjakob Peipei Ping Integrated omics dissection of proteome dynamics during cardiac remodeling
description	Transcriptome data provide only a partial picture of disease states. Here, via integration of transcript-, protein abundance and protein turnover data for a mouse model of cardiac hypertrophy, the authors uncover additional disease gene signatures, and show that turnover data sheds unique light on posttranslational regulation.
format	article
author	Edward Lau Quan Cao Maggie P. Y. Lam Jie Wang Dominic C. M. Ng Brian J. Bleakley Jessica M. Lee David A. Liem Ding Wang Henning Hermjakob Peipei Ping
author_facet	Edward Lau Quan Cao Maggie P. Y. Lam Jie Wang Dominic C. M. Ng Brian J. Bleakley Jessica M. Lee David A. Liem Ding Wang Henning Hermjakob Peipei Ping
author_sort	Edward Lau
title	Integrated omics dissection of proteome dynamics during cardiac remodeling
title_short	Integrated omics dissection of proteome dynamics during cardiac remodeling
title_full	Integrated omics dissection of proteome dynamics during cardiac remodeling
title_fullStr	Integrated omics dissection of proteome dynamics during cardiac remodeling
title_full_unstemmed	Integrated omics dissection of proteome dynamics during cardiac remodeling
title_sort	integrated omics dissection of proteome dynamics during cardiac remodeling
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/735fc1b56e0a42518ad0a64c538beba9
work_keys_str_mv	AT edwardlau integratedomicsdissectionofproteomedynamicsduringcardiacremodeling AT quancao integratedomicsdissectionofproteomedynamicsduringcardiacremodeling AT maggiepylam integratedomicsdissectionofproteomedynamicsduringcardiacremodeling AT jiewang integratedomicsdissectionofproteomedynamicsduringcardiacremodeling AT dominiccmng integratedomicsdissectionofproteomedynamicsduringcardiacremodeling AT brianjbleakley integratedomicsdissectionofproteomedynamicsduringcardiacremodeling AT jessicamlee integratedomicsdissectionofproteomedynamicsduringcardiacremodeling AT davidaliem integratedomicsdissectionofproteomedynamicsduringcardiacremodeling AT dingwang integratedomicsdissectionofproteomedynamicsduringcardiacremodeling AT henninghermjakob integratedomicsdissectionofproteomedynamicsduringcardiacremodeling AT peipeiping integratedomicsdissectionofproteomedynamicsduringcardiacremodeling
_version_	1718387031496720384

Integrated omics dissection of proteome dynamics during cardiac remodeling

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