Construction and Validation of New Nomograms to Predict Risk and Prognostic Factors of Breast Cancer Bone Metastasis in Asian Females: A Population-Based Retrospective Study

Junsen Deng,1,&ast; Di Zhang,2,&ast; Wenming Zhang,1 Junhui Li2 1Department of Orthopedics Surgery, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Zhengzhou, 45000, Henan, People’s Republic of China; 2Department of Spine Surgery, Luoyang Orthopedic Hosp...

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Autores principales:	Deng J, Zhang D, Zhang W, Li J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	breast cancer bone metastasis prognosis nomogram seer Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/736723f42a9e4870a3543c45bfaddccd
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spelling	oai:doaj.org-article:736723f42a9e4870a3543c45bfaddccd2021-11-25T18:55:29ZConstruction and Validation of New Nomograms to Predict Risk and Prognostic Factors of Breast Cancer Bone Metastasis in Asian Females: A Population-Based Retrospective Study1178-7074https://doaj.org/article/736723f42a9e4870a3543c45bfaddccd2021-11-01T00:00:00Zhttps://www.dovepress.com/construction-and-validation-of-new-nomograms-to-predict-risk-and-progn-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Junsen Deng,1,&ast; Di Zhang,2,&ast; Wenming Zhang,1 Junhui Li2 1Department of Orthopedics Surgery, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Zhengzhou, 45000, Henan, People’s Republic of China; 2Department of Spine Surgery, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Zhengzhou, 45000, Henan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Junsen DengDepartment of Orthopedics Surgery, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Zhengzhou, 45000, Henan, People’s Republic of ChinaEmail djstougao@126.comPurpose: To construct a breast cancer bone-only metastasis (BCBM) risk and prognostic model for Asian females and provide a reference for treatment selection in breast cancer (BC) patients with bone-only metastasis (BM).Patients and Methods: The data for newly diagnosed female patients of Asian Pacific Islander (API) ethnicity between 2010 and 2018 were obtained from the Surveillance, Epidemiology, and End Results database. A total of 16,972 patients were identified. Logistic regression analyses were used to establish a risk model for BCBM. Cox proportional hazards regression analyses were used to construct nomograms for the prognosis of BC and BCBM. Subsequently, the degree of discrimination of the nomogram was evaluated using the consistency index (C-index) and receiver operating curve.Results: The main independent risk factors of BM in Asian females with BC were primary site surgery (p< 0.0001), ER (p=0.0015), and T-stage (p=0.0046). The C-index values in the training and validation cohorts were 0.933 and 0.941, respectively. The main independent risk factors of the prognosis of BC were age (p< 0.001), summary stage (p< 0.001), and grade (p=0.002). The C-index values of 5-year overall survival (OS) in the training and validation cohorts were 0.823 and 0.804, respectively. The risk factors of the prognosis of Asian females with BCBM were subtype (p< 0.001), histology (p< 0.001), and grade (p=0.033). The C-index values of 5-year OS in the training and validation cohorts were 0.793 and 0.723, respectively.Conclusion: Using population-based analysis, this study constructed a prediction model for the risk and prognosis of BM in Asian females with BC. Another newly constructed model was effective in predicting OS in BCBM patients. These models can help prevent skeletal-related events and weigh the risks and benefits of surgery for metastatic lesions in BCBM patients.Keywords: breast cancer, bone metastasis, prognosis, nomogram, SEERDeng JZhang DZhang WLi JDove Medical Pressarticlebreast cancerbone metastasisprognosisnomogramseerMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8881-8902 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer bone metastasis prognosis nomogram seer Medicine (General) R5-920
spellingShingle	breast cancer bone metastasis prognosis nomogram seer Medicine (General) R5-920 Deng J Zhang D Zhang W Li J Construction and Validation of New Nomograms to Predict Risk and Prognostic Factors of Breast Cancer Bone Metastasis in Asian Females: A Population-Based Retrospective Study
description	Junsen Deng,1,&ast; Di Zhang,2,&ast; Wenming Zhang,1 Junhui Li2 1Department of Orthopedics Surgery, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Zhengzhou, 45000, Henan, People’s Republic of China; 2Department of Spine Surgery, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Zhengzhou, 45000, Henan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Junsen DengDepartment of Orthopedics Surgery, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Zhengzhou, 45000, Henan, People’s Republic of ChinaEmail djstougao@126.comPurpose: To construct a breast cancer bone-only metastasis (BCBM) risk and prognostic model for Asian females and provide a reference for treatment selection in breast cancer (BC) patients with bone-only metastasis (BM).Patients and Methods: The data for newly diagnosed female patients of Asian Pacific Islander (API) ethnicity between 2010 and 2018 were obtained from the Surveillance, Epidemiology, and End Results database. A total of 16,972 patients were identified. Logistic regression analyses were used to establish a risk model for BCBM. Cox proportional hazards regression analyses were used to construct nomograms for the prognosis of BC and BCBM. Subsequently, the degree of discrimination of the nomogram was evaluated using the consistency index (C-index) and receiver operating curve.Results: The main independent risk factors of BM in Asian females with BC were primary site surgery (p< 0.0001), ER (p=0.0015), and T-stage (p=0.0046). The C-index values in the training and validation cohorts were 0.933 and 0.941, respectively. The main independent risk factors of the prognosis of BC were age (p< 0.001), summary stage (p< 0.001), and grade (p=0.002). The C-index values of 5-year overall survival (OS) in the training and validation cohorts were 0.823 and 0.804, respectively. The risk factors of the prognosis of Asian females with BCBM were subtype (p< 0.001), histology (p< 0.001), and grade (p=0.033). The C-index values of 5-year OS in the training and validation cohorts were 0.793 and 0.723, respectively.Conclusion: Using population-based analysis, this study constructed a prediction model for the risk and prognosis of BM in Asian females with BC. Another newly constructed model was effective in predicting OS in BCBM patients. These models can help prevent skeletal-related events and weigh the risks and benefits of surgery for metastatic lesions in BCBM patients.Keywords: breast cancer, bone metastasis, prognosis, nomogram, SEER
format	article
author	Deng J Zhang D Zhang W Li J
author_facet	Deng J Zhang D Zhang W Li J
author_sort	Deng J
title	Construction and Validation of New Nomograms to Predict Risk and Prognostic Factors of Breast Cancer Bone Metastasis in Asian Females: A Population-Based Retrospective Study
title_short	Construction and Validation of New Nomograms to Predict Risk and Prognostic Factors of Breast Cancer Bone Metastasis in Asian Females: A Population-Based Retrospective Study
title_full	Construction and Validation of New Nomograms to Predict Risk and Prognostic Factors of Breast Cancer Bone Metastasis in Asian Females: A Population-Based Retrospective Study
title_fullStr	Construction and Validation of New Nomograms to Predict Risk and Prognostic Factors of Breast Cancer Bone Metastasis in Asian Females: A Population-Based Retrospective Study
title_full_unstemmed	Construction and Validation of New Nomograms to Predict Risk and Prognostic Factors of Breast Cancer Bone Metastasis in Asian Females: A Population-Based Retrospective Study
title_sort	construction and validation of new nomograms to predict risk and prognostic factors of breast cancer bone metastasis in asian females: a population-based retrospective study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/736723f42a9e4870a3543c45bfaddccd
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Construction and Validation of New Nomograms to Predict Risk and Prognostic Factors of Breast Cancer Bone Metastasis in Asian Females: A Population-Based Retrospective Study

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