Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease

Abstract The joint disease called pararamosis is an occupational disease caused by accidental contact with bristles of the caterpillar Premolis semirufa. The chronic inflammatory process narrows the joint space and causes alterations in bone structure and cartilage degeneration, leading to joint sti...

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Autores principales:	Giselle Pidde, Milton Y. Nishiyama, Ursula Castro de Oliveira, Isadora M. Villas-Boas, Adriana F. Paes-Leme, Inácio L. Junqueira-de-Azevedo, Rafael Marques-Porto, Carla C. Squaiella-Baptistão, Denise V. Tambourgi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/736b93df965e40d5943af7832e4cf9a0
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spelling	oai:doaj.org-article:736b93df965e40d5943af7832e4cf9a02021-12-02T10:49:11ZIntegrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease10.1038/s41598-020-79769-y2045-2322https://doaj.org/article/736b93df965e40d5943af7832e4cf9a02021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79769-yhttps://doaj.org/toc/2045-2322Abstract The joint disease called pararamosis is an occupational disease caused by accidental contact with bristles of the caterpillar Premolis semirufa. The chronic inflammatory process narrows the joint space and causes alterations in bone structure and cartilage degeneration, leading to joint stiffness. Aiming to determine the bristle components that could be responsible for this peculiar envenomation, in this work we have examined the toxin composition of the caterpillar bristles extract and compared it with the differentially expressed genes (DEGs) in synovial biopsies of patients affected with rheumatoid arthritis (RA) and osteoarthritis (OA). Among the proteins identified, 129 presented an average of 63% homology with human proteins and shared important conserved domains. Among the human homologous proteins, we identified seven DEGs upregulated in synovial biopsies from RA or OA patients using meta-analysis. This approach allowed us to suggest possible toxins from the pararama bristles that could be responsible for starting the joint disease observed in pararamosis. Moreover, the study of pararamosis, in turn, may lead to the discovery of specific pharmacological targets related to the early stages of articular diseases.Giselle PiddeMilton Y. NishiyamaUrsula Castro de OliveiraIsadora M. Villas-BoasAdriana F. Paes-LemeInácio L. Junqueira-de-AzevedoRafael Marques-PortoCarla C. Squaiella-BaptistãoDenise V. TambourgiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giselle Pidde Milton Y. Nishiyama Ursula Castro de Oliveira Isadora M. Villas-Boas Adriana F. Paes-Leme Inácio L. Junqueira-de-Azevedo Rafael Marques-Porto Carla C. Squaiella-Baptistão Denise V. Tambourgi Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease
description	Abstract The joint disease called pararamosis is an occupational disease caused by accidental contact with bristles of the caterpillar Premolis semirufa. The chronic inflammatory process narrows the joint space and causes alterations in bone structure and cartilage degeneration, leading to joint stiffness. Aiming to determine the bristle components that could be responsible for this peculiar envenomation, in this work we have examined the toxin composition of the caterpillar bristles extract and compared it with the differentially expressed genes (DEGs) in synovial biopsies of patients affected with rheumatoid arthritis (RA) and osteoarthritis (OA). Among the proteins identified, 129 presented an average of 63% homology with human proteins and shared important conserved domains. Among the human homologous proteins, we identified seven DEGs upregulated in synovial biopsies from RA or OA patients using meta-analysis. This approach allowed us to suggest possible toxins from the pararama bristles that could be responsible for starting the joint disease observed in pararamosis. Moreover, the study of pararamosis, in turn, may lead to the discovery of specific pharmacological targets related to the early stages of articular diseases.
format	article
author	Giselle Pidde Milton Y. Nishiyama Ursula Castro de Oliveira Isadora M. Villas-Boas Adriana F. Paes-Leme Inácio L. Junqueira-de-Azevedo Rafael Marques-Porto Carla C. Squaiella-Baptistão Denise V. Tambourgi
author_facet	Giselle Pidde Milton Y. Nishiyama Ursula Castro de Oliveira Isadora M. Villas-Boas Adriana F. Paes-Leme Inácio L. Junqueira-de-Azevedo Rafael Marques-Porto Carla C. Squaiella-Baptistão Denise V. Tambourgi
author_sort	Giselle Pidde
title	Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease
title_short	Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease
title_full	Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease
title_fullStr	Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease
title_full_unstemmed	Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease
title_sort	integrative multiomics analysis of premolis semirufa caterpillar venom in the search for molecules leading to a joint disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/736b93df965e40d5943af7832e4cf9a0
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Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease

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