The Role of Iron in Cancer Progression
Iron is an essential trace element for the human body, and its deficiency or excess can induce a variety of biological processes. Plenty of evidences have shown that iron metabolism is closely related to the occurrence and development of tumors. In addition, iron plays an important role in cell deat...
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Frontiers Media S.A.
2021
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| Acceso en línea: | https://doaj.org/article/737230df8e06450aba27451893e8271e |
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oai:doaj.org-article:737230df8e06450aba27451893e8271e2021-11-10T06:36:40ZThe Role of Iron in Cancer Progression2234-943X10.3389/fonc.2021.778492https://doaj.org/article/737230df8e06450aba27451893e8271e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.778492/fullhttps://doaj.org/toc/2234-943XIron is an essential trace element for the human body, and its deficiency or excess can induce a variety of biological processes. Plenty of evidences have shown that iron metabolism is closely related to the occurrence and development of tumors. In addition, iron plays an important role in cell death, which is very important for the development of potential strategies for tumor treatment. Here, we reviewed the latest research about iron metabolism disorders in various types of tumors, the functions and properties of iron in ferroptosis and ferritinophagy, and new opportunities for iron-based on treatment methods for tumors, providing more information regarding the prevention and treatment of tumors.Qianqian GuoLiwen LiShanshan HouZiqiao YuanChenhui LiWenzhou ZhangLufeng ZhengXiaoman LiFrontiers Media S.A.articleironcancerferroptosisferritinophagyprognostictherapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
iron cancer ferroptosis ferritinophagy prognostic therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
iron cancer ferroptosis ferritinophagy prognostic therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Qianqian Guo Liwen Li Shanshan Hou Ziqiao Yuan Chenhui Li Wenzhou Zhang Lufeng Zheng Xiaoman Li The Role of Iron in Cancer Progression |
| description |
Iron is an essential trace element for the human body, and its deficiency or excess can induce a variety of biological processes. Plenty of evidences have shown that iron metabolism is closely related to the occurrence and development of tumors. In addition, iron plays an important role in cell death, which is very important for the development of potential strategies for tumor treatment. Here, we reviewed the latest research about iron metabolism disorders in various types of tumors, the functions and properties of iron in ferroptosis and ferritinophagy, and new opportunities for iron-based on treatment methods for tumors, providing more information regarding the prevention and treatment of tumors. |
| format |
article |
| author |
Qianqian Guo Liwen Li Shanshan Hou Ziqiao Yuan Chenhui Li Wenzhou Zhang Lufeng Zheng Xiaoman Li |
| author_facet |
Qianqian Guo Liwen Li Shanshan Hou Ziqiao Yuan Chenhui Li Wenzhou Zhang Lufeng Zheng Xiaoman Li |
| author_sort |
Qianqian Guo |
| title |
The Role of Iron in Cancer Progression |
| title_short |
The Role of Iron in Cancer Progression |
| title_full |
The Role of Iron in Cancer Progression |
| title_fullStr |
The Role of Iron in Cancer Progression |
| title_full_unstemmed |
The Role of Iron in Cancer Progression |
| title_sort |
role of iron in cancer progression |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/737230df8e06450aba27451893e8271e |
| work_keys_str_mv |
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| _version_ |
1718440479099453440 |