Exploring the link between cadmium and psoriasis in a nationally representative sample

Abstract Psoriasis, a skin inflammatory disease, originates from dysregulated interactions of the immune system. Cadmium, an environment pollutant, increases the levels of inflammation markers and influences the immune system. To clarify the relationship between cadmium and psoriasis, 5,927 particip...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fang-Yih Liaw, Wei-Liang Chen, Tung-Wei Kao, Yaw-Wen Chang, Ching-Fu Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7373f23e19774e72a6d2776b6133c131
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7373f23e19774e72a6d2776b6133c131
record_format	dspace
spelling	oai:doaj.org-article:7373f23e19774e72a6d2776b6133c1312021-12-02T12:32:30ZExploring the link between cadmium and psoriasis in a nationally representative sample10.1038/s41598-017-01827-92045-2322https://doaj.org/article/7373f23e19774e72a6d2776b6133c1312017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01827-9https://doaj.org/toc/2045-2322Abstract Psoriasis, a skin inflammatory disease, originates from dysregulated interactions of the immune system. Cadmium, an environment pollutant, increases the levels of inflammation markers and influences the immune system. To clarify the relationship between cadmium and psoriasis, 5,927 participants, ≥20 years, in the National Health and Nutrition Examination Survey (NHANES) 2003–2006 were studied. Psoriasis severity was assessed using self-reported dermatology questionnaires. Cadmium was measured using blood chemistry. Three adjusted models were applied for the interaction between serum cadmium and severity of psoriasis. Psoriasis patients had significantly higher blood cadmium (0.67 vs. 0.52 μg/L, p = 0.006). There was a strong linear increase in predicted blood cadmium values with an increase in severity of psoriasis (p for trend = 0.002). The β coefficient of the predicted serum cadmium in the “few patches to extensive psoriasis” group was 0.234 (p = 0.002) after adjusting covariates. Participants with severe psoriasis have higher blood cadmium. Environmental exposure to cadmium can predispose to the worsening of psoriasis. Although there are still limitations in this study, such as not included treatment data, these results have substantial public health implications for the general population, as they demonstrate the importance of cadmium exposure prevention, particularly among psoriasis patients.Fang-Yih LiawWei-Liang ChenTung-Wei KaoYaw-Wen ChangChing-Fu HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fang-Yih Liaw Wei-Liang Chen Tung-Wei Kao Yaw-Wen Chang Ching-Fu Huang Exploring the link between cadmium and psoriasis in a nationally representative sample
description	Abstract Psoriasis, a skin inflammatory disease, originates from dysregulated interactions of the immune system. Cadmium, an environment pollutant, increases the levels of inflammation markers and influences the immune system. To clarify the relationship between cadmium and psoriasis, 5,927 participants, ≥20 years, in the National Health and Nutrition Examination Survey (NHANES) 2003–2006 were studied. Psoriasis severity was assessed using self-reported dermatology questionnaires. Cadmium was measured using blood chemistry. Three adjusted models were applied for the interaction between serum cadmium and severity of psoriasis. Psoriasis patients had significantly higher blood cadmium (0.67 vs. 0.52 μg/L, p = 0.006). There was a strong linear increase in predicted blood cadmium values with an increase in severity of psoriasis (p for trend = 0.002). The β coefficient of the predicted serum cadmium in the “few patches to extensive psoriasis” group was 0.234 (p = 0.002) after adjusting covariates. Participants with severe psoriasis have higher blood cadmium. Environmental exposure to cadmium can predispose to the worsening of psoriasis. Although there are still limitations in this study, such as not included treatment data, these results have substantial public health implications for the general population, as they demonstrate the importance of cadmium exposure prevention, particularly among psoriasis patients.
format	article
author	Fang-Yih Liaw Wei-Liang Chen Tung-Wei Kao Yaw-Wen Chang Ching-Fu Huang
author_facet	Fang-Yih Liaw Wei-Liang Chen Tung-Wei Kao Yaw-Wen Chang Ching-Fu Huang
author_sort	Fang-Yih Liaw
title	Exploring the link between cadmium and psoriasis in a nationally representative sample
title_short	Exploring the link between cadmium and psoriasis in a nationally representative sample
title_full	Exploring the link between cadmium and psoriasis in a nationally representative sample
title_fullStr	Exploring the link between cadmium and psoriasis in a nationally representative sample
title_full_unstemmed	Exploring the link between cadmium and psoriasis in a nationally representative sample
title_sort	exploring the link between cadmium and psoriasis in a nationally representative sample
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7373f23e19774e72a6d2776b6133c131
work_keys_str_mv	AT fangyihliaw exploringthelinkbetweencadmiumandpsoriasisinanationallyrepresentativesample AT weiliangchen exploringthelinkbetweencadmiumandpsoriasisinanationallyrepresentativesample AT tungweikao exploringthelinkbetweencadmiumandpsoriasisinanationallyrepresentativesample AT yawwenchang exploringthelinkbetweencadmiumandpsoriasisinanationallyrepresentativesample AT chingfuhuang exploringthelinkbetweencadmiumandpsoriasisinanationallyrepresentativesample
_version_	1718394040758566912

Exploring the link between cadmium and psoriasis in a nationally representative sample

Ejemplares similares