Ischemic brain infarcts and vasculitis in histoplasmosis of the central nervous system: A case report and review of the literature

Histoplasmosis is one of the most common endemic mycoses affecting immunocompromised individuals in the United States and Latin America. Involvement of the central nervous system carries higher mortality rates and worse prognosis, given its resemblance to stroke, vasculitis, and meningitis of other...

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Autores principales:	Roberto Pineda-Reyes, Irene Riestra Guiance, Avi Landman, Minh Quang Ho
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Mycoses Fungal lung diseases Stroke Lacunar stroke Central nervous system Vasculitis Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/737b14db20c64aaa982c7a160d78670e
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spelling	oai:doaj.org-article:737b14db20c64aaa982c7a160d78670e2021-11-24T04:30:59ZIschemic brain infarcts and vasculitis in histoplasmosis of the central nervous system: A case report and review of the literature2214-250910.1016/j.idcr.2021.e01347https://doaj.org/article/737b14db20c64aaa982c7a160d78670e2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2214250921003036https://doaj.org/toc/2214-2509Histoplasmosis is one of the most common endemic mycoses affecting immunocompromised individuals in the United States and Latin America. Involvement of the central nervous system carries higher mortality rates and worse prognosis, given its resemblance to stroke, vasculitis, and meningitis of other etiologies. The diagnosis is challenging, due to its subtle clinical presentation and the poor sensitivity of the cerebrospinal fluid culture. Herein the authors present a case of a middle-aged man with HIV, who presented with intermittent headaches exacerbated by an oculomotor nerve palsy, concerning for acute stroke. A diagnosis of central nervous system histoplasmosis was made, and his neurological deficits subsided after initiation of treatment. The stroke-like syndrome in this scenario may be secondary to granulomatous vasculitis of small caliber cerebral blood vessels. Histoplasmosis of the central nervous system remains a challenging diagnosis, which requires a high index of suspicion by the clinician for an early institution of therapy in order to improve outcomes.Roberto Pineda-ReyesIrene Riestra GuianceAvi LandmanMinh Quang HoElsevierarticleMycosesFungal lung diseasesStrokeLacunar strokeCentral nervous systemVasculitisInfectious and parasitic diseasesRC109-216ENIDCases, Vol 26, Iss , Pp e01347- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mycoses Fungal lung diseases Stroke Lacunar stroke Central nervous system Vasculitis Infectious and parasitic diseases RC109-216
spellingShingle	Mycoses Fungal lung diseases Stroke Lacunar stroke Central nervous system Vasculitis Infectious and parasitic diseases RC109-216 Roberto Pineda-Reyes Irene Riestra Guiance Avi Landman Minh Quang Ho Ischemic brain infarcts and vasculitis in histoplasmosis of the central nervous system: A case report and review of the literature
description	Histoplasmosis is one of the most common endemic mycoses affecting immunocompromised individuals in the United States and Latin America. Involvement of the central nervous system carries higher mortality rates and worse prognosis, given its resemblance to stroke, vasculitis, and meningitis of other etiologies. The diagnosis is challenging, due to its subtle clinical presentation and the poor sensitivity of the cerebrospinal fluid culture. Herein the authors present a case of a middle-aged man with HIV, who presented with intermittent headaches exacerbated by an oculomotor nerve palsy, concerning for acute stroke. A diagnosis of central nervous system histoplasmosis was made, and his neurological deficits subsided after initiation of treatment. The stroke-like syndrome in this scenario may be secondary to granulomatous vasculitis of small caliber cerebral blood vessels. Histoplasmosis of the central nervous system remains a challenging diagnosis, which requires a high index of suspicion by the clinician for an early institution of therapy in order to improve outcomes.
format	article
author	Roberto Pineda-Reyes Irene Riestra Guiance Avi Landman Minh Quang Ho
author_facet	Roberto Pineda-Reyes Irene Riestra Guiance Avi Landman Minh Quang Ho
author_sort	Roberto Pineda-Reyes
title	Ischemic brain infarcts and vasculitis in histoplasmosis of the central nervous system: A case report and review of the literature
title_short	Ischemic brain infarcts and vasculitis in histoplasmosis of the central nervous system: A case report and review of the literature
title_full	Ischemic brain infarcts and vasculitis in histoplasmosis of the central nervous system: A case report and review of the literature
title_fullStr	Ischemic brain infarcts and vasculitis in histoplasmosis of the central nervous system: A case report and review of the literature
title_full_unstemmed	Ischemic brain infarcts and vasculitis in histoplasmosis of the central nervous system: A case report and review of the literature
title_sort	ischemic brain infarcts and vasculitis in histoplasmosis of the central nervous system: a case report and review of the literature
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/737b14db20c64aaa982c7a160d78670e
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Ischemic brain infarcts and vasculitis in histoplasmosis of the central nervous system: A case report and review of the literature

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