Macropinocytosis confers resistance to therapies targeting cancer anabolism

Macropinocytosis allows cancer cells to cope with nutrient stress. Here, the authors use a selective, genetic approach to inhibit macropinocytosis and show that consuming necrotic cell debris via macropinocytosis—necrocytosis—affords resistance to many therapies that target biosynthesis.

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Detalles Bibliográficos
Autores principales:	Vaishali Jayashankar, Aimee L. Edinger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/737b7cdd758c4542bc38e47261135578
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spelling	oai:doaj.org-article:737b7cdd758c4542bc38e472611355782021-12-02T14:40:51ZMacropinocytosis confers resistance to therapies targeting cancer anabolism10.1038/s41467-020-14928-32041-1723https://doaj.org/article/737b7cdd758c4542bc38e472611355782020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14928-3https://doaj.org/toc/2041-1723Macropinocytosis allows cancer cells to cope with nutrient stress. Here, the authors use a selective, genetic approach to inhibit macropinocytosis and show that consuming necrotic cell debris via macropinocytosis—necrocytosis—affords resistance to many therapies that target biosynthesis.Vaishali JayashankarAimee L. EdingerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vaishali Jayashankar Aimee L. Edinger Macropinocytosis confers resistance to therapies targeting cancer anabolism
description	Macropinocytosis allows cancer cells to cope with nutrient stress. Here, the authors use a selective, genetic approach to inhibit macropinocytosis and show that consuming necrotic cell debris via macropinocytosis—necrocytosis—affords resistance to many therapies that target biosynthesis.
format	article
author	Vaishali Jayashankar Aimee L. Edinger
author_facet	Vaishali Jayashankar Aimee L. Edinger
author_sort	Vaishali Jayashankar
title	Macropinocytosis confers resistance to therapies targeting cancer anabolism
title_short	Macropinocytosis confers resistance to therapies targeting cancer anabolism
title_full	Macropinocytosis confers resistance to therapies targeting cancer anabolism
title_fullStr	Macropinocytosis confers resistance to therapies targeting cancer anabolism
title_full_unstemmed	Macropinocytosis confers resistance to therapies targeting cancer anabolism
title_sort	macropinocytosis confers resistance to therapies targeting cancer anabolism
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/737b7cdd758c4542bc38e47261135578
work_keys_str_mv	AT vaishalijayashankar macropinocytosisconfersresistancetotherapiestargetingcanceranabolism AT aimeeledinger macropinocytosisconfersresistancetotherapiestargetingcanceranabolism
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Macropinocytosis confers resistance to therapies targeting cancer anabolism

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