Macropinocytosis confers resistance to therapies targeting cancer anabolism

Macropinocytosis allows cancer cells to cope with nutrient stress. Here, the authors use a selective, genetic approach to inhibit macropinocytosis and show that consuming necrotic cell debris via macropinocytosis—necrocytosis—affords resistance to many therapies that target biosynthesis.

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Detalles Bibliográficos
Autores principales: Vaishali Jayashankar, Aimee L. Edinger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/737b7cdd758c4542bc38e47261135578
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