Elucidating the fundamental fibrotic processes driving abdominal adhesion formation

Abdominal adhesions are a common cause of bowel obstruction, but knowledge regarding adhesion biology and anti-adhesion therapies remains limited. Here the authors report a systematic analysis of mouse and human adhesion tissues demonstrating that visceral fibroblast JUN and associated PDGFRA expres...

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Autores principales:	Deshka S. Foster, Clement D. Marshall, Gunsagar S. Gulati, Malini S. Chinta, Alan Nguyen, Ankit Salhotra, R. Ellen Jones, Austin Burcham, Tristan Lerbs, Lu Cui, Megan E. King, Ashley L. Titan, R. Chase Ransom, Anoop Manjunath, Michael S. Hu, Charles P. Blackshear, Shamik Mascharak, Alessandra L. Moore, Jeffrey A. Norton, Cindy J. Kin, Andrew A. Shelton, Michael Januszyk, Geoffrey C. Gurtner, Gerlinde Wernig, Michael T. Longaker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/737d1dd933494725beaf1af250bea456
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spelling	oai:doaj.org-article:737d1dd933494725beaf1af250bea4562021-12-02T18:50:53ZElucidating the fundamental fibrotic processes driving abdominal adhesion formation10.1038/s41467-020-17883-12041-1723https://doaj.org/article/737d1dd933494725beaf1af250bea4562020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17883-1https://doaj.org/toc/2041-1723Abdominal adhesions are a common cause of bowel obstruction, but knowledge regarding adhesion biology and anti-adhesion therapies remains limited. Here the authors report a systematic analysis of mouse and human adhesion tissues demonstrating that visceral fibroblast JUN and associated PDGFRA expression promote adhesions, and JUN suppression can prevent adhesion formation.Deshka S. FosterClement D. MarshallGunsagar S. GulatiMalini S. ChintaAlan NguyenAnkit SalhotraR. Ellen JonesAustin BurchamTristan LerbsLu CuiMegan E. KingAshley L. TitanR. Chase RansomAnoop ManjunathMichael S. HuCharles P. BlackshearShamik MascharakAlessandra L. MooreJeffrey A. NortonCindy J. KinAndrew A. SheltonMichael JanuszykGeoffrey C. GurtnerGerlinde WernigMichael T. LongakerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Deshka S. Foster Clement D. Marshall Gunsagar S. Gulati Malini S. Chinta Alan Nguyen Ankit Salhotra R. Ellen Jones Austin Burcham Tristan Lerbs Lu Cui Megan E. King Ashley L. Titan R. Chase Ransom Anoop Manjunath Michael S. Hu Charles P. Blackshear Shamik Mascharak Alessandra L. Moore Jeffrey A. Norton Cindy J. Kin Andrew A. Shelton Michael Januszyk Geoffrey C. Gurtner Gerlinde Wernig Michael T. Longaker Elucidating the fundamental fibrotic processes driving abdominal adhesion formation
description	Abdominal adhesions are a common cause of bowel obstruction, but knowledge regarding adhesion biology and anti-adhesion therapies remains limited. Here the authors report a systematic analysis of mouse and human adhesion tissues demonstrating that visceral fibroblast JUN and associated PDGFRA expression promote adhesions, and JUN suppression can prevent adhesion formation.
format	article
author	Deshka S. Foster Clement D. Marshall Gunsagar S. Gulati Malini S. Chinta Alan Nguyen Ankit Salhotra R. Ellen Jones Austin Burcham Tristan Lerbs Lu Cui Megan E. King Ashley L. Titan R. Chase Ransom Anoop Manjunath Michael S. Hu Charles P. Blackshear Shamik Mascharak Alessandra L. Moore Jeffrey A. Norton Cindy J. Kin Andrew A. Shelton Michael Januszyk Geoffrey C. Gurtner Gerlinde Wernig Michael T. Longaker
author_facet	Deshka S. Foster Clement D. Marshall Gunsagar S. Gulati Malini S. Chinta Alan Nguyen Ankit Salhotra R. Ellen Jones Austin Burcham Tristan Lerbs Lu Cui Megan E. King Ashley L. Titan R. Chase Ransom Anoop Manjunath Michael S. Hu Charles P. Blackshear Shamik Mascharak Alessandra L. Moore Jeffrey A. Norton Cindy J. Kin Andrew A. Shelton Michael Januszyk Geoffrey C. Gurtner Gerlinde Wernig Michael T. Longaker
author_sort	Deshka S. Foster
title	Elucidating the fundamental fibrotic processes driving abdominal adhesion formation
title_short	Elucidating the fundamental fibrotic processes driving abdominal adhesion formation
title_full	Elucidating the fundamental fibrotic processes driving abdominal adhesion formation
title_fullStr	Elucidating the fundamental fibrotic processes driving abdominal adhesion formation
title_full_unstemmed	Elucidating the fundamental fibrotic processes driving abdominal adhesion formation
title_sort	elucidating the fundamental fibrotic processes driving abdominal adhesion formation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/737d1dd933494725beaf1af250bea456
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Elucidating the fundamental fibrotic processes driving abdominal adhesion formation

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