Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma

Liposarcoma (LPS) is a rare cancer that can acquire resistance to chemotherapy. Here, the authors map super-enhancers in LPS, finding BET-protein dependent mechanisms that can be targeted by a BET protein degrader, which also can overcome acquired resistance to chemotherapy in LPS.

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Autores principales:	Ye Chen, Liang Xu, Anand Mayakonda, Mo-Li Huang, Deepika Kanojia, Tuan Zea Tan, Pushkar Dakle, Ruby Yu-Tong Lin, Xin-Yu Ke, Jonathan W. Said, Jianxiang Chen, Sigal Gery, Ling-Wen Ding, Yan-Yi Jiang, Angela Pang, Mark Edward Puhaindran, Boon Cher Goh, H. Phillip Koeffler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/737f0325add94122b8c3c1a96fabd32f
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spelling	oai:doaj.org-article:737f0325add94122b8c3c1a96fabd32f2021-12-02T15:35:53ZBromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma10.1038/s41467-019-09257-z2041-1723https://doaj.org/article/737f0325add94122b8c3c1a96fabd32f2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09257-zhttps://doaj.org/toc/2041-1723Liposarcoma (LPS) is a rare cancer that can acquire resistance to chemotherapy. Here, the authors map super-enhancers in LPS, finding BET-protein dependent mechanisms that can be targeted by a BET protein degrader, which also can overcome acquired resistance to chemotherapy in LPS.Ye ChenLiang XuAnand MayakondaMo-Li HuangDeepika KanojiaTuan Zea TanPushkar DakleRuby Yu-Tong LinXin-Yu KeJonathan W. SaidJianxiang ChenSigal GeryLing-Wen DingYan-Yi JiangAngela PangMark Edward PuhaindranBoon Cher GohH. Phillip KoefflerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ye Chen Liang Xu Anand Mayakonda Mo-Li Huang Deepika Kanojia Tuan Zea Tan Pushkar Dakle Ruby Yu-Tong Lin Xin-Yu Ke Jonathan W. Said Jianxiang Chen Sigal Gery Ling-Wen Ding Yan-Yi Jiang Angela Pang Mark Edward Puhaindran Boon Cher Goh H. Phillip Koeffler Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma
description	Liposarcoma (LPS) is a rare cancer that can acquire resistance to chemotherapy. Here, the authors map super-enhancers in LPS, finding BET-protein dependent mechanisms that can be targeted by a BET protein degrader, which also can overcome acquired resistance to chemotherapy in LPS.
format	article
author	Ye Chen Liang Xu Anand Mayakonda Mo-Li Huang Deepika Kanojia Tuan Zea Tan Pushkar Dakle Ruby Yu-Tong Lin Xin-Yu Ke Jonathan W. Said Jianxiang Chen Sigal Gery Ling-Wen Ding Yan-Yi Jiang Angela Pang Mark Edward Puhaindran Boon Cher Goh H. Phillip Koeffler
author_facet	Ye Chen Liang Xu Anand Mayakonda Mo-Li Huang Deepika Kanojia Tuan Zea Tan Pushkar Dakle Ruby Yu-Tong Lin Xin-Yu Ke Jonathan W. Said Jianxiang Chen Sigal Gery Ling-Wen Ding Yan-Yi Jiang Angela Pang Mark Edward Puhaindran Boon Cher Goh H. Phillip Koeffler
author_sort	Ye Chen
title	Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma
title_short	Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma
title_full	Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma
title_fullStr	Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma
title_full_unstemmed	Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma
title_sort	bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/737f0325add94122b8c3c1a96fabd32f
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Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma

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