De-novo multilayering in fibrovascular pigment epithelial detachment

Abstract This study describes the occurrence of multilayered pigment-epithelial detachment (MLPED) as a De-novo phenomenon (DN-MLPED) and compare the features with multi-layering secondary to chronic anti-vascular endothelial growth factor (anti-VEGF) therapy (s-MLPED). We did a retrospective evalua...

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Autores principales:	Manoj Soman, Jay U. Sheth, Asmita Indurkar, Padmanabhan Meleth, Unnikrishnan Nair
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7382fd9b7b3e46eab87b2614487398f2
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spelling	oai:doaj.org-article:7382fd9b7b3e46eab87b2614487398f22021-12-02T15:09:15ZDe-novo multilayering in fibrovascular pigment epithelial detachment10.1038/s41598-021-96746-12045-2322https://doaj.org/article/7382fd9b7b3e46eab87b2614487398f22021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96746-1https://doaj.org/toc/2045-2322Abstract This study describes the occurrence of multilayered pigment-epithelial detachment (MLPED) as a De-novo phenomenon (DN-MLPED) and compare the features with multi-layering secondary to chronic anti-vascular endothelial growth factor (anti-VEGF) therapy (s-MLPED). We did a retrospective evaluation of spectral-domain optical coherence tomography (SD-OCT) features, treatment-profile, and visual-acuity (VA) outcomes in eyes with MLPED. Out of 17 eyes with MLPED, 7 eyes had DN-MLPED and 10 eyes had s-MLPED. There was no significant difference in baseline and final VA between the groups. At the final visit, no significant visual improvement was noted in both the groups, although a possible trend towards an improvement was seen in DN-MLPED eyes while the s-MLPED demonstrated a declining trend (DN-MLPED—LogMAR-BCVA: Baseline = 0.79 [∼ 20/123] ± 0.91; Final = 0.76 [∼ 20/115] ± 0.73; p = 0.87; s-MLPED—LogMAR BCVA: Baseline = 0.43 [∼ 20/54] ± 0.68; Final = 0.94 [∼ 20/174] ± 0.71; p = 0.06). Moreover, after presentation, the median number of injections in DN-MLPED eyes were significantly lower compared to s-MLPED eyes (DN-MLPED:4; s-MLPED:12; p = 0.03) (Median follow-up: DN-MLPED = 26 months; s-MLPED = 54 months; p = 0.15). Subretinal hyperreflective-material (SHRM) deposition heralded the onset of multilayering and was seen to progress in all DN-PED eyes and 1/4 eyes of s-MLPED. To conclude, MLPED is a unique form of cicatrizing fibrovascular-PED which can evolve denovo too. Long-standing disease with intermittent or low-grade activity can potentially explain this unique phenomenon. With fewer anti-VEGF therapy, the de-novo MLPED eyes show more visual stability as compared to s-MLPED eyes.Manoj SomanJay U. ShethAsmita IndurkarPadmanabhan MelethUnnikrishnan NairNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manoj Soman Jay U. Sheth Asmita Indurkar Padmanabhan Meleth Unnikrishnan Nair De-novo multilayering in fibrovascular pigment epithelial detachment
description	Abstract This study describes the occurrence of multilayered pigment-epithelial detachment (MLPED) as a De-novo phenomenon (DN-MLPED) and compare the features with multi-layering secondary to chronic anti-vascular endothelial growth factor (anti-VEGF) therapy (s-MLPED). We did a retrospective evaluation of spectral-domain optical coherence tomography (SD-OCT) features, treatment-profile, and visual-acuity (VA) outcomes in eyes with MLPED. Out of 17 eyes with MLPED, 7 eyes had DN-MLPED and 10 eyes had s-MLPED. There was no significant difference in baseline and final VA between the groups. At the final visit, no significant visual improvement was noted in both the groups, although a possible trend towards an improvement was seen in DN-MLPED eyes while the s-MLPED demonstrated a declining trend (DN-MLPED—LogMAR-BCVA: Baseline = 0.79 [∼ 20/123] ± 0.91; Final = 0.76 [∼ 20/115] ± 0.73; p = 0.87; s-MLPED—LogMAR BCVA: Baseline = 0.43 [∼ 20/54] ± 0.68; Final = 0.94 [∼ 20/174] ± 0.71; p = 0.06). Moreover, after presentation, the median number of injections in DN-MLPED eyes were significantly lower compared to s-MLPED eyes (DN-MLPED:4; s-MLPED:12; p = 0.03) (Median follow-up: DN-MLPED = 26 months; s-MLPED = 54 months; p = 0.15). Subretinal hyperreflective-material (SHRM) deposition heralded the onset of multilayering and was seen to progress in all DN-PED eyes and 1/4 eyes of s-MLPED. To conclude, MLPED is a unique form of cicatrizing fibrovascular-PED which can evolve denovo too. Long-standing disease with intermittent or low-grade activity can potentially explain this unique phenomenon. With fewer anti-VEGF therapy, the de-novo MLPED eyes show more visual stability as compared to s-MLPED eyes.
format	article
author	Manoj Soman Jay U. Sheth Asmita Indurkar Padmanabhan Meleth Unnikrishnan Nair
author_facet	Manoj Soman Jay U. Sheth Asmita Indurkar Padmanabhan Meleth Unnikrishnan Nair
author_sort	Manoj Soman
title	De-novo multilayering in fibrovascular pigment epithelial detachment
title_short	De-novo multilayering in fibrovascular pigment epithelial detachment
title_full	De-novo multilayering in fibrovascular pigment epithelial detachment
title_fullStr	De-novo multilayering in fibrovascular pigment epithelial detachment
title_full_unstemmed	De-novo multilayering in fibrovascular pigment epithelial detachment
title_sort	de-novo multilayering in fibrovascular pigment epithelial detachment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7382fd9b7b3e46eab87b2614487398f2
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De-novo multilayering in fibrovascular pigment epithelial detachment

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