A non-lethal traumatic/hemorrhagic insult strongly modulates the compartment-specific PAI-1 response in the subsequent polymicrobial sepsis.

A non-lethal traumatic/hemorrhagic insult strongly modulates the compartment-specific PAI-1 response in the subsequent polymicrobial sepsis.

<h4>Introduction</h4>Plasminogen activator inhibitor 1 (PAI-1) is a key factor in trauma- and sepsis-induced coagulopathy. We examined how trauma-hemorrhage (TH) modulates PAI-1 responses in subsequent cecal ligation and puncture (CLP)-induced sepsis, and the association of PAI-1 with se...

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Autores principales: Pierre Raeven, Alma Salibasic, Susanne Drechsler, Katrin Maria Weixelbaumer, Mohammad Jafarmadar, Martijn van Griensven, Soheyl Bahrami, Marcin Filip Osuchowski
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/738315d5776e4f0a99738fbe4536ea95
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