Better tolerance of preservative-free latanoprost compared to preserved glaucoma eye drops: the 12-month real-life FREE study

Mario A Economou,1 Helene Kolstad Laukeland,2,3 Iwona Grabska-Liberek,4 Jean-François Rouland5 1Anterior Segment Department, St Erik’s Eye Hospital, Karolinska Institute, Stockholm, Sweden; 2Department of Ophthalmology, University Hospital, Trondheim, Norway; 3Department of Lab...

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Autores principales:	Economou MA, Laukeland HK, Grabska-Liberek I, Rouland JF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Glaucoma prostaglandins preservative-free latanoprost patient satisfaction conjunctival hyperemia ocular surface diseases Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/73837d2e8a2542d1b4b98674f8f4ebc1
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spelling	oai:doaj.org-article:73837d2e8a2542d1b4b98674f8f4ebc12021-12-02T03:24:19ZBetter tolerance of preservative-free latanoprost compared to preserved glaucoma eye drops: the 12-month real-life FREE study1177-5483https://doaj.org/article/73837d2e8a2542d1b4b98674f8f4ebc12018-11-01T00:00:00Zhttps://www.dovepress.com/better-tolerance-of-preservative-free-latanoprost-compared-to-preserve-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Mario A Economou,1 Helene Kolstad Laukeland,2,3 Iwona Grabska-Liberek,4 Jean-François Rouland5 1Anterior Segment Department, St Erik’s Eye Hospital, Karolinska Institute, Stockholm, Sweden; 2Department of Ophthalmology, University Hospital, Trondheim, Norway; 3Department of Laboratory Medicine, Norwegian University of Science and Technology, Trondheim, Norway; 4Department of Ophthalmology, Ophthalmology Clinic Postgraduate Centre of Medical Education, Warszawa, Poland; 5Department of Ophtalmology, Claude Huriez Hospital, University Hospital, Lille, France Background: Lack of efficacy due to bad compliance caused by intolerance issues is the main reason for a change to a better tolerated ocular treatment, such as using preservative-free (PF) eye drops.Aim: To assess the efficacy and local tolerance after 12 months and patient satisfaction regarding local treatment tolerance and handling at inclusion and after 6 months of PF latanoprost compared to preserved glaucoma eye drops.Methods: This was an international, prospective, and observational real-life study. Up to three visits, one at inclusion and two follow-up visits (one after 6 and one after 12 months) were planned. Efficacy, local tolerance, and patient satisfaction were the main evaluation criteria.Results: Data from 721 patients were available for the statistical analysis. Overall, 64.8% (467/721) of patients switched treatment before inclusion: 62.2% in the preserved and 68.9% in the PF latanoprost group. IOP values were similar between PF latanoprost and preserved eye drops and remained stable at all visits. Ocular signs and symptoms improved after switching to PF latanoprost; the prevalence of conjunctival hyperemia was significantly lower (P=0.0015) at both follow-up visits. At follow-up visit 1, 49.5% of the patients who switched to PF latanoprost decreased or stopped the use of artificial tears. Satisfaction regarding tolerance in patients using PF latanoprost improved significantly after the switch from preserved eye drops to PF latanoprost (88.9% and 42.5%, respectively, P<0.0001).Conclusion: This first real-life study showed that PF latanoprost was as efficacious but better tolerated than preserved eye drops over a sustained period of 12 months, while providing a significantly higher patient satisfaction and potentially allowing improvement in the patient’s daily life. Keywords: glaucoma, prostaglandins, preservative-free latanoprost, patient satisfaction, conjunctival hyperemia, ocular surface diseases Economou MALaukeland HKGrabska-Liberek IRouland JFDove Medical PressarticleGlaucomaprostaglandinspreservative-free latanoprostpatient satisfactionconjunctival hyperemiaocular surface diseasesOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 2399-2407 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Glaucoma prostaglandins preservative-free latanoprost patient satisfaction conjunctival hyperemia ocular surface diseases Ophthalmology RE1-994
spellingShingle	Glaucoma prostaglandins preservative-free latanoprost patient satisfaction conjunctival hyperemia ocular surface diseases Ophthalmology RE1-994 Economou MA Laukeland HK Grabska-Liberek I Rouland JF Better tolerance of preservative-free latanoprost compared to preserved glaucoma eye drops: the 12-month real-life FREE study
description	Mario A Economou,1 Helene Kolstad Laukeland,2,3 Iwona Grabska-Liberek,4 Jean-François Rouland5 1Anterior Segment Department, St Erik’s Eye Hospital, Karolinska Institute, Stockholm, Sweden; 2Department of Ophthalmology, University Hospital, Trondheim, Norway; 3Department of Laboratory Medicine, Norwegian University of Science and Technology, Trondheim, Norway; 4Department of Ophthalmology, Ophthalmology Clinic Postgraduate Centre of Medical Education, Warszawa, Poland; 5Department of Ophtalmology, Claude Huriez Hospital, University Hospital, Lille, France Background: Lack of efficacy due to bad compliance caused by intolerance issues is the main reason for a change to a better tolerated ocular treatment, such as using preservative-free (PF) eye drops.Aim: To assess the efficacy and local tolerance after 12 months and patient satisfaction regarding local treatment tolerance and handling at inclusion and after 6 months of PF latanoprost compared to preserved glaucoma eye drops.Methods: This was an international, prospective, and observational real-life study. Up to three visits, one at inclusion and two follow-up visits (one after 6 and one after 12 months) were planned. Efficacy, local tolerance, and patient satisfaction were the main evaluation criteria.Results: Data from 721 patients were available for the statistical analysis. Overall, 64.8% (467/721) of patients switched treatment before inclusion: 62.2% in the preserved and 68.9% in the PF latanoprost group. IOP values were similar between PF latanoprost and preserved eye drops and remained stable at all visits. Ocular signs and symptoms improved after switching to PF latanoprost; the prevalence of conjunctival hyperemia was significantly lower (P=0.0015) at both follow-up visits. At follow-up visit 1, 49.5% of the patients who switched to PF latanoprost decreased or stopped the use of artificial tears. Satisfaction regarding tolerance in patients using PF latanoprost improved significantly after the switch from preserved eye drops to PF latanoprost (88.9% and 42.5%, respectively, P<0.0001).Conclusion: This first real-life study showed that PF latanoprost was as efficacious but better tolerated than preserved eye drops over a sustained period of 12 months, while providing a significantly higher patient satisfaction and potentially allowing improvement in the patient’s daily life. Keywords: glaucoma, prostaglandins, preservative-free latanoprost, patient satisfaction, conjunctival hyperemia, ocular surface diseases
format	article
author	Economou MA Laukeland HK Grabska-Liberek I Rouland JF
author_facet	Economou MA Laukeland HK Grabska-Liberek I Rouland JF
author_sort	Economou MA
title	Better tolerance of preservative-free latanoprost compared to preserved glaucoma eye drops: the 12-month real-life FREE study
title_short	Better tolerance of preservative-free latanoprost compared to preserved glaucoma eye drops: the 12-month real-life FREE study
title_full	Better tolerance of preservative-free latanoprost compared to preserved glaucoma eye drops: the 12-month real-life FREE study
title_fullStr	Better tolerance of preservative-free latanoprost compared to preserved glaucoma eye drops: the 12-month real-life FREE study
title_full_unstemmed	Better tolerance of preservative-free latanoprost compared to preserved glaucoma eye drops: the 12-month real-life FREE study
title_sort	better tolerance of preservative-free latanoprost compared to preserved glaucoma eye drops: the 12-month real-life free study
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/73837d2e8a2542d1b4b98674f8f4ebc1
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Better tolerance of preservative-free latanoprost compared to preserved glaucoma eye drops: the 12-month real-life FREE study

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