Wild type, dEX3 and 2B survivin isoforms localize to the tumor cell plasma membrane, are secreted in exosomes, and interact with extracellular tubulin

The Inhibitor of Apoptosis Protein survivin (svn) is upregulated in nearly all types of cancer and represents a promising therapeutic target. Localization to specific subcellular compartments and interactions with various binding partners allow survivin to play diverse roles in apoptosis resistance...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sheila Figel, Meaghan Birkemeier, Sanam Sahjram Dharma, Tara Barone, Emma Steinmetz, Michael Ciesielski, Robert Fenstermaker
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Survivin Survivin-2B Survivin-dEX3 Exosome Plasma membrane Tubulin Biology (General) QH301-705.5 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/7384950b302c4a2e83e8329711c4cf61
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7384950b302c4a2e83e8329711c4cf61
record_format	dspace
spelling	oai:doaj.org-article:7384950b302c4a2e83e8329711c4cf612021-11-22T04:27:26ZWild type, dEX3 and 2B survivin isoforms localize to the tumor cell plasma membrane, are secreted in exosomes, and interact with extracellular tubulin2405-580810.1016/j.bbrep.2021.101174https://doaj.org/article/7384950b302c4a2e83e8329711c4cf612021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405580821002685https://doaj.org/toc/2405-5808The Inhibitor of Apoptosis Protein survivin (svn) is upregulated in nearly all types of cancer and represents a promising therapeutic target. Localization to specific subcellular compartments and interactions with various binding partners allow survivin to play diverse roles in apoptosis resistance and mitosis. Survivin has recently been found in two extracellular compartments: the outer plasma membrane and secreted exosomes. In addition to svn-wt, splice variants svn-dEX3 and svn-2B are also overexpressed in human tumors. Here we show that, similarly to svn-wt, svn-dEX3 and svn-2B can be displayed on the outer plasma membrane, and secreted in exosomes. Additionally, we have identified a novel interaction of all three forms of survivin with secreted tubulin.Sheila FigelMeaghan BirkemeierSanam Sahjram DharmaTara BaroneEmma SteinmetzMichael CiesielskiRobert FenstermakerElsevierarticleSurvivinSurvivin-2BSurvivin-dEX3ExosomePlasma membraneTubulinBiology (General)QH301-705.5BiochemistryQD415-436ENBiochemistry and Biophysics Reports, Vol 28, Iss , Pp 101174- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Survivin Survivin-2B Survivin-dEX3 Exosome Plasma membrane Tubulin Biology (General) QH301-705.5 Biochemistry QD415-436
spellingShingle	Survivin Survivin-2B Survivin-dEX3 Exosome Plasma membrane Tubulin Biology (General) QH301-705.5 Biochemistry QD415-436 Sheila Figel Meaghan Birkemeier Sanam Sahjram Dharma Tara Barone Emma Steinmetz Michael Ciesielski Robert Fenstermaker Wild type, dEX3 and 2B survivin isoforms localize to the tumor cell plasma membrane, are secreted in exosomes, and interact with extracellular tubulin
description	The Inhibitor of Apoptosis Protein survivin (svn) is upregulated in nearly all types of cancer and represents a promising therapeutic target. Localization to specific subcellular compartments and interactions with various binding partners allow survivin to play diverse roles in apoptosis resistance and mitosis. Survivin has recently been found in two extracellular compartments: the outer plasma membrane and secreted exosomes. In addition to svn-wt, splice variants svn-dEX3 and svn-2B are also overexpressed in human tumors. Here we show that, similarly to svn-wt, svn-dEX3 and svn-2B can be displayed on the outer plasma membrane, and secreted in exosomes. Additionally, we have identified a novel interaction of all three forms of survivin with secreted tubulin.
format	article
author	Sheila Figel Meaghan Birkemeier Sanam Sahjram Dharma Tara Barone Emma Steinmetz Michael Ciesielski Robert Fenstermaker
author_facet	Sheila Figel Meaghan Birkemeier Sanam Sahjram Dharma Tara Barone Emma Steinmetz Michael Ciesielski Robert Fenstermaker
author_sort	Sheila Figel
title	Wild type, dEX3 and 2B survivin isoforms localize to the tumor cell plasma membrane, are secreted in exosomes, and interact with extracellular tubulin
title_short	Wild type, dEX3 and 2B survivin isoforms localize to the tumor cell plasma membrane, are secreted in exosomes, and interact with extracellular tubulin
title_full	Wild type, dEX3 and 2B survivin isoforms localize to the tumor cell plasma membrane, are secreted in exosomes, and interact with extracellular tubulin
title_fullStr	Wild type, dEX3 and 2B survivin isoforms localize to the tumor cell plasma membrane, are secreted in exosomes, and interact with extracellular tubulin
title_full_unstemmed	Wild type, dEX3 and 2B survivin isoforms localize to the tumor cell plasma membrane, are secreted in exosomes, and interact with extracellular tubulin
title_sort	wild type, dex3 and 2b survivin isoforms localize to the tumor cell plasma membrane, are secreted in exosomes, and interact with extracellular tubulin
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/7384950b302c4a2e83e8329711c4cf61
work_keys_str_mv	AT sheilafigel wildtypedex3and2bsurvivinisoformslocalizetothetumorcellplasmamembranearesecretedinexosomesandinteractwithextracellulartubulin AT meaghanbirkemeier wildtypedex3and2bsurvivinisoformslocalizetothetumorcellplasmamembranearesecretedinexosomesandinteractwithextracellulartubulin AT sanamsahjramdharma wildtypedex3and2bsurvivinisoformslocalizetothetumorcellplasmamembranearesecretedinexosomesandinteractwithextracellulartubulin AT tarabarone wildtypedex3and2bsurvivinisoformslocalizetothetumorcellplasmamembranearesecretedinexosomesandinteractwithextracellulartubulin AT emmasteinmetz wildtypedex3and2bsurvivinisoformslocalizetothetumorcellplasmamembranearesecretedinexosomesandinteractwithextracellulartubulin AT michaelciesielski wildtypedex3and2bsurvivinisoformslocalizetothetumorcellplasmamembranearesecretedinexosomesandinteractwithextracellulartubulin AT robertfenstermaker wildtypedex3and2bsurvivinisoformslocalizetothetumorcellplasmamembranearesecretedinexosomesandinteractwithextracellulartubulin
_version_	1718418167630397440

Wild type, dEX3 and 2B survivin isoforms localize to the tumor cell plasma membrane, are secreted in exosomes, and interact with extracellular tubulin

Ejemplares similares