Wild type, dEX3 and 2B survivin isoforms localize to the tumor cell plasma membrane, are secreted in exosomes, and interact with extracellular tubulin

The Inhibitor of Apoptosis Protein survivin (svn) is upregulated in nearly all types of cancer and represents a promising therapeutic target. Localization to specific subcellular compartments and interactions with various binding partners allow survivin to play diverse roles in apoptosis resistance...

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Autores principales: Sheila Figel, Meaghan Birkemeier, Sanam Sahjram Dharma, Tara Barone, Emma Steinmetz, Michael Ciesielski, Robert Fenstermaker
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/7384950b302c4a2e83e8329711c4cf61
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