On-line range verification for proton beam therapy using spherical ionoacoustic waves with resonant frequency

Abstract In contrast to conventional X-ray therapy, proton beam therapy (PBT) can confine radiation doses to tumours because of the presence of the Bragg peak. However, the precision of the treatment is currently limited by the uncertainty in the beam range. Recently, a unique range verification met...

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Autores principales:	Taisuke Takayanagi, Tomoki Uesaka, Yuta Nakamura, Mehmet Burcin Unlu, Yasutoshi Kuriyama, Tomonori Uesugi, Yoshihiro Ishi, Nobuki Kudo, Masanori Kobayashi, Kikuo Umegaki, Satoshi Tomioka, Taeko Matsuura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/738560bb3dd84384b0afdf6ce903d946
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spelling	oai:doaj.org-article:738560bb3dd84384b0afdf6ce903d9462021-12-02T15:09:22ZOn-line range verification for proton beam therapy using spherical ionoacoustic waves with resonant frequency10.1038/s41598-020-77422-22045-2322https://doaj.org/article/738560bb3dd84384b0afdf6ce903d9462020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77422-2https://doaj.org/toc/2045-2322Abstract In contrast to conventional X-ray therapy, proton beam therapy (PBT) can confine radiation doses to tumours because of the presence of the Bragg peak. However, the precision of the treatment is currently limited by the uncertainty in the beam range. Recently, a unique range verification methodology has been proposed based on simulation studies that exploit spherical ionoacoustic waves with resonant frequency (SPIREs). SPIREs are emitted from spherical gold markers in tumours initially introduced for accurate patient positioning when the proton beam is injected. These waves have a remarkable property: their amplitude is linearly correlated with the residual beam range at the marker position. Here, we present proof-of-principle experiments using short-pulsed proton beams at the clinical dose to demonstrate the feasibility of using SPIREs for beam-range verification with submillimetre accuracy. These results should substantially contribute to reducing the range uncertainty in future PBT applications.Taisuke TakayanagiTomoki UesakaYuta NakamuraMehmet Burcin UnluYasutoshi KuriyamaTomonori UesugiYoshihiro IshiNobuki KudoMasanori KobayashiKikuo UmegakiSatoshi TomiokaTaeko MatsuuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Taisuke Takayanagi Tomoki Uesaka Yuta Nakamura Mehmet Burcin Unlu Yasutoshi Kuriyama Tomonori Uesugi Yoshihiro Ishi Nobuki Kudo Masanori Kobayashi Kikuo Umegaki Satoshi Tomioka Taeko Matsuura On-line range verification for proton beam therapy using spherical ionoacoustic waves with resonant frequency
description	Abstract In contrast to conventional X-ray therapy, proton beam therapy (PBT) can confine radiation doses to tumours because of the presence of the Bragg peak. However, the precision of the treatment is currently limited by the uncertainty in the beam range. Recently, a unique range verification methodology has been proposed based on simulation studies that exploit spherical ionoacoustic waves with resonant frequency (SPIREs). SPIREs are emitted from spherical gold markers in tumours initially introduced for accurate patient positioning when the proton beam is injected. These waves have a remarkable property: their amplitude is linearly correlated with the residual beam range at the marker position. Here, we present proof-of-principle experiments using short-pulsed proton beams at the clinical dose to demonstrate the feasibility of using SPIREs for beam-range verification with submillimetre accuracy. These results should substantially contribute to reducing the range uncertainty in future PBT applications.
format	article
author	Taisuke Takayanagi Tomoki Uesaka Yuta Nakamura Mehmet Burcin Unlu Yasutoshi Kuriyama Tomonori Uesugi Yoshihiro Ishi Nobuki Kudo Masanori Kobayashi Kikuo Umegaki Satoshi Tomioka Taeko Matsuura
author_facet	Taisuke Takayanagi Tomoki Uesaka Yuta Nakamura Mehmet Burcin Unlu Yasutoshi Kuriyama Tomonori Uesugi Yoshihiro Ishi Nobuki Kudo Masanori Kobayashi Kikuo Umegaki Satoshi Tomioka Taeko Matsuura
author_sort	Taisuke Takayanagi
title	On-line range verification for proton beam therapy using spherical ionoacoustic waves with resonant frequency
title_short	On-line range verification for proton beam therapy using spherical ionoacoustic waves with resonant frequency
title_full	On-line range verification for proton beam therapy using spherical ionoacoustic waves with resonant frequency
title_fullStr	On-line range verification for proton beam therapy using spherical ionoacoustic waves with resonant frequency
title_full_unstemmed	On-line range verification for proton beam therapy using spherical ionoacoustic waves with resonant frequency
title_sort	on-line range verification for proton beam therapy using spherical ionoacoustic waves with resonant frequency
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/738560bb3dd84384b0afdf6ce903d946
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On-line range verification for proton beam therapy using spherical ionoacoustic waves with resonant frequency

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