Nanostructured Coating of Non-Crystalline Tantalum Pentoxide on Polyetheretherketone Enhances RBMS Cells/HGE Cells Adhesion

Zhiying Pang,1,* Zhangyi Pan,1,* Min Ma,1 Zhiyan Xu,2 Shiqi Mei,2 Zengxin Jiang,3 Feng Yin1 1Department of Joint Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, People’s Republic of China; 2Key Laboratory for Ultrafine Materials of Ministry of Educa...

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Autores principales:	Pang Z, Pan Z, Ma M, Xu Z, Mei S, Jiang Z, Yin F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	polyetheretherketone tantalum pentoxide nanostructured coating cytocompatibility dental implant applications Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7388d8e0998c4627af9d854285990f95
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spelling	oai:doaj.org-article:7388d8e0998c4627af9d854285990f952021-12-02T13:43:56ZNanostructured Coating of Non-Crystalline Tantalum Pentoxide on Polyetheretherketone Enhances RBMS Cells/HGE Cells Adhesion1178-2013https://doaj.org/article/7388d8e0998c4627af9d854285990f952021-01-01T00:00:00Zhttps://www.dovepress.com/nanostructured-coating-of-non-crystalline-tantalum-pentoxide-on-polyet-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Zhiying Pang,1,* Zhangyi Pan,1,* Min Ma,1 Zhiyan Xu,2 Shiqi Mei,2 Zengxin Jiang,3 Feng Yin1 1Department of Joint Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, People’s Republic of China; 2Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, People’s Republic of China; 3Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zengxin Jiang Tel +86 21-64041990Email Dr_Jiangzx@163.comFeng Yin Tel +86 21-64041990Email 001yinfeng@sina.comPurpose: As a dental material, polyetheretherketone (PEEK) is bioinert that does not induce cellular response and bone/gingival tissues regeneration. This study was to develop bioactive coating on PEEK and investigate the effects of coating on cellular response.Materials and Methods: Tantalum pentoxide (TP) coating was fabricated on PEEK surface by vacuum evaporation and responses of rat bone marrow mesenchymal stem (RBMS) cells/human gingival epithelial (HGE) were studied.Results: A dense coating (around 400 nm in thickness) of TP was closely combined with PEEK (PKTP). Moreover, the coating was non-crystalline TP, which contained many small humps (around 10 nm in size), exhibiting a nanostructured surface. In addition, the roughness, hydrophilicity, surface energy, and protein adsorption of PKTP were remarkably higher than that of PEEK. Furthermore, the responses (adhesion, proliferation, and osteogenic gene expression) of RBMS cells, and responses (adhesion and proliferation) of HGE cells to PKTP were remarkably improved in comparison with PEEK. It could be suggested that the nanostructured coating of TP on PEEK played crucial roles in inducing the responses of RBMS/HGE cells.Conclusion: PKTP with elevated surface performances and outstanding cytocompatibility might have enormous potential for dental implant application.Keywords: polyetheretherketone, tantalum pentoxide, nanostructured coating, cytocompatibility, dental implant applicationsPang ZPan ZMa MXu ZMei SJiang ZYin FDove Medical Pressarticlepolyetheretherketonetantalum pentoxidenanostructured coatingcytocompatibilitydental implant applicationsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 725-740 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polyetheretherketone tantalum pentoxide nanostructured coating cytocompatibility dental implant applications Medicine (General) R5-920
spellingShingle	polyetheretherketone tantalum pentoxide nanostructured coating cytocompatibility dental implant applications Medicine (General) R5-920 Pang Z Pan Z Ma M Xu Z Mei S Jiang Z Yin F Nanostructured Coating of Non-Crystalline Tantalum Pentoxide on Polyetheretherketone Enhances RBMS Cells/HGE Cells Adhesion
description	Zhiying Pang,1,* Zhangyi Pan,1,* Min Ma,1 Zhiyan Xu,2 Shiqi Mei,2 Zengxin Jiang,3 Feng Yin1 1Department of Joint Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, People’s Republic of China; 2Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, People’s Republic of China; 3Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zengxin Jiang Tel +86 21-64041990Email Dr_Jiangzx@163.comFeng Yin Tel +86 21-64041990Email 001yinfeng@sina.comPurpose: As a dental material, polyetheretherketone (PEEK) is bioinert that does not induce cellular response and bone/gingival tissues regeneration. This study was to develop bioactive coating on PEEK and investigate the effects of coating on cellular response.Materials and Methods: Tantalum pentoxide (TP) coating was fabricated on PEEK surface by vacuum evaporation and responses of rat bone marrow mesenchymal stem (RBMS) cells/human gingival epithelial (HGE) were studied.Results: A dense coating (around 400 nm in thickness) of TP was closely combined with PEEK (PKTP). Moreover, the coating was non-crystalline TP, which contained many small humps (around 10 nm in size), exhibiting a nanostructured surface. In addition, the roughness, hydrophilicity, surface energy, and protein adsorption of PKTP were remarkably higher than that of PEEK. Furthermore, the responses (adhesion, proliferation, and osteogenic gene expression) of RBMS cells, and responses (adhesion and proliferation) of HGE cells to PKTP were remarkably improved in comparison with PEEK. It could be suggested that the nanostructured coating of TP on PEEK played crucial roles in inducing the responses of RBMS/HGE cells.Conclusion: PKTP with elevated surface performances and outstanding cytocompatibility might have enormous potential for dental implant application.Keywords: polyetheretherketone, tantalum pentoxide, nanostructured coating, cytocompatibility, dental implant applications
format	article
author	Pang Z Pan Z Ma M Xu Z Mei S Jiang Z Yin F
author_facet	Pang Z Pan Z Ma M Xu Z Mei S Jiang Z Yin F
author_sort	Pang Z
title	Nanostructured Coating of Non-Crystalline Tantalum Pentoxide on Polyetheretherketone Enhances RBMS Cells/HGE Cells Adhesion
title_short	Nanostructured Coating of Non-Crystalline Tantalum Pentoxide on Polyetheretherketone Enhances RBMS Cells/HGE Cells Adhesion
title_full	Nanostructured Coating of Non-Crystalline Tantalum Pentoxide on Polyetheretherketone Enhances RBMS Cells/HGE Cells Adhesion
title_fullStr	Nanostructured Coating of Non-Crystalline Tantalum Pentoxide on Polyetheretherketone Enhances RBMS Cells/HGE Cells Adhesion
title_full_unstemmed	Nanostructured Coating of Non-Crystalline Tantalum Pentoxide on Polyetheretherketone Enhances RBMS Cells/HGE Cells Adhesion
title_sort	nanostructured coating of non-crystalline tantalum pentoxide on polyetheretherketone enhances rbms cells/hge cells adhesion
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/7388d8e0998c4627af9d854285990f95
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Nanostructured Coating of Non-Crystalline Tantalum Pentoxide on Polyetheretherketone Enhances RBMS Cells/HGE Cells Adhesion

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