Interleukin 17 enhances bone morphogenetic protein-2-induced ectopic bone formation

Abstract Interleukin 17 (IL-17) stimulates the osteogenic differentiation of progenitor cells in vitro through a synergy with bone morphogenetic protein (BMP)-2. This study investigates whether the diverse responses mediated by IL-17 in vivo also lead to enhanced BMP-2-induced bone formation. Since...

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Autores principales:	M. Croes, M. C. Kruyt, W. M. Groen, K. M. A. van Dorenmalen, W. J. A. Dhert, F. C. Öner, J. Alblas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/738aad42290648b0a143de8cf1da883a
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spelling	oai:doaj.org-article:738aad42290648b0a143de8cf1da883a2021-12-02T16:08:13ZInterleukin 17 enhances bone morphogenetic protein-2-induced ectopic bone formation10.1038/s41598-018-25564-92045-2322https://doaj.org/article/738aad42290648b0a143de8cf1da883a2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25564-9https://doaj.org/toc/2045-2322Abstract Interleukin 17 (IL-17) stimulates the osteogenic differentiation of progenitor cells in vitro through a synergy with bone morphogenetic protein (BMP)-2. This study investigates whether the diverse responses mediated by IL-17 in vivo also lead to enhanced BMP-2-induced bone formation. Since IL-17 is known to induce osteoclastogenesis, we studied the interactions between IL-17 and BMP-2 in ceramic scaffolds either or not carrying a coating with the bisphosphonate zoledronic acid (ZOL). Histological evaluation revealed that IL-17 alone did not induce any osteoclasts at day 10. On the other hand, BMP-2 clearly stimulated early tissue ingrowth and osteoclastogenesis. Both of these processes were blocked in presence of ZOL. IL-17 signaling restored early vascularized connective tissue formation and osteoclastogenesis induced by BMP-2 in ZOL-coated scaffolds. After 12 weeks, the bone volume induced by co-delivery of BMP-2 and IL-17 was doubled as compared to that induced by BMP-2 alone. We conclude that IL-17 has osteo-stimulatory effects through a synergy with bone-inductive BMP-2. Although local and single application of IL-17 does not mediate osteoclast formation, it could promote other processes involved in bone formation such as connective tissue ingrowth. The use of IL-17 may contribute to the development of improved bone graft substitutes.M. CroesM. C. KruytW. M. GroenK. M. A. van DorenmalenW. J. A. DhertF. C. ÖnerJ. AlblasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Croes M. C. Kruyt W. M. Groen K. M. A. van Dorenmalen W. J. A. Dhert F. C. Öner J. Alblas Interleukin 17 enhances bone morphogenetic protein-2-induced ectopic bone formation
description	Abstract Interleukin 17 (IL-17) stimulates the osteogenic differentiation of progenitor cells in vitro through a synergy with bone morphogenetic protein (BMP)-2. This study investigates whether the diverse responses mediated by IL-17 in vivo also lead to enhanced BMP-2-induced bone formation. Since IL-17 is known to induce osteoclastogenesis, we studied the interactions between IL-17 and BMP-2 in ceramic scaffolds either or not carrying a coating with the bisphosphonate zoledronic acid (ZOL). Histological evaluation revealed that IL-17 alone did not induce any osteoclasts at day 10. On the other hand, BMP-2 clearly stimulated early tissue ingrowth and osteoclastogenesis. Both of these processes were blocked in presence of ZOL. IL-17 signaling restored early vascularized connective tissue formation and osteoclastogenesis induced by BMP-2 in ZOL-coated scaffolds. After 12 weeks, the bone volume induced by co-delivery of BMP-2 and IL-17 was doubled as compared to that induced by BMP-2 alone. We conclude that IL-17 has osteo-stimulatory effects through a synergy with bone-inductive BMP-2. Although local and single application of IL-17 does not mediate osteoclast formation, it could promote other processes involved in bone formation such as connective tissue ingrowth. The use of IL-17 may contribute to the development of improved bone graft substitutes.
format	article
author	M. Croes M. C. Kruyt W. M. Groen K. M. A. van Dorenmalen W. J. A. Dhert F. C. Öner J. Alblas
author_facet	M. Croes M. C. Kruyt W. M. Groen K. M. A. van Dorenmalen W. J. A. Dhert F. C. Öner J. Alblas
author_sort	M. Croes
title	Interleukin 17 enhances bone morphogenetic protein-2-induced ectopic bone formation
title_short	Interleukin 17 enhances bone morphogenetic protein-2-induced ectopic bone formation
title_full	Interleukin 17 enhances bone morphogenetic protein-2-induced ectopic bone formation
title_fullStr	Interleukin 17 enhances bone morphogenetic protein-2-induced ectopic bone formation
title_full_unstemmed	Interleukin 17 enhances bone morphogenetic protein-2-induced ectopic bone formation
title_sort	interleukin 17 enhances bone morphogenetic protein-2-induced ectopic bone formation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/738aad42290648b0a143de8cf1da883a
work_keys_str_mv	AT mcroes interleukin17enhancesbonemorphogeneticprotein2inducedectopicboneformation AT mckruyt interleukin17enhancesbonemorphogeneticprotein2inducedectopicboneformation AT wmgroen interleukin17enhancesbonemorphogeneticprotein2inducedectopicboneformation AT kmavandorenmalen interleukin17enhancesbonemorphogeneticprotein2inducedectopicboneformation AT wjadhert interleukin17enhancesbonemorphogeneticprotein2inducedectopicboneformation AT fconer interleukin17enhancesbonemorphogeneticprotein2inducedectopicboneformation AT jalblas interleukin17enhancesbonemorphogeneticprotein2inducedectopicboneformation
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Interleukin 17 enhances bone morphogenetic protein-2-induced ectopic bone formation

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