Rapid host strain improvement by in vivo rearrangement of a synthetic yeast chromosome

The Sc2.0 project has built the Synthetic Chromosome Rearrangement and Modification by LoxP-mediated Evolution (SCRaMbLE) system into their synthetic chromosomes. Here the authors use SCRaMbLE to rapidly develop, diversify and screen strains for diverse production and growth characteristics.

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Bibliographic Details
Main Authors: B. A. Blount, G-O. F. Gowers, J. C. H. Ho, R. Ledesma-Amaro, D. Jovicevic, R. M. McKiernan, Z. X. Xie, B. Z. Li, Y. J. Yuan, T. Ellis
Format: article
Language:EN
Published: Nature Portfolio 2018
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Online Access:https://doaj.org/article/738aaf777cd743a989f5123aa889b4c7
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