Relationship of coronary collateral circulation with eosinophils in patients with unstable angina pectoris

Jun Wang,1,* Qun Li,2,* Shi-jing Li,1 De-zhao Wang,2 Bu-xing Chen2 1Department of Cardiology, Beijing Mentougou District Hospital, 2Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China *These authors contributed equally to&am...

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Autores principales:	Wang J, Li Q, Li SJ, Wang DZ, Chen BX
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	unstable angina pectoris coronary collateral circulation eosinophils coronary artery disease Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/738c3d60d89f48bf9d662b451bfb59b2
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spelling	oai:doaj.org-article:738c3d60d89f48bf9d662b451bfb59b22021-12-02T02:13:26ZRelationship of coronary collateral circulation with eosinophils in patients with unstable angina pectoris1178-1998https://doaj.org/article/738c3d60d89f48bf9d662b451bfb59b22016-01-01T00:00:00Zhttps://www.dovepress.com/relationship-of-coronary-collateral-circulation-with-eosinophils-in-pa-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Jun Wang,1,* Qun Li,2,* Shi-jing Li,1 De-zhao Wang,2 Bu-xing Chen2 1Department of Cardiology, Beijing Mentougou District Hospital, 2Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China *These authors contributed equally to this work Background: Eosinophils (EOS) have been associated with prognosis of patients with coronary artery disease, and those who showed plenitudinous coronary collateral circulation (CCC) often have good clinical consequences. However, the relationship between EOS and CCC was seldom reported. Objective: To investigate the relationship between EOS and CCC development in patients with unstable angina pectoris (UAP).Methods: The study population consisted of 502 consecutive patients with UAP who underwent coronary angiography and coronary stenosis ≥80%. CCC was graded according to the Rentrop grading system of 0–3. Rentrop grades of 0 and 1 indicated low-grade CCC group, whereas grades 2 and 3 indicated high-grade CCC group.Results: The EOS was significantly higher in the high-grade CCC group compared with the low-grade CCC group. In multiple logistic regression analysis, EOS (odds ratio: 1.969; 95% confidence interval [CI]: 1.210–3.3205; P=0.006) and neutrophil count (odds ratio: 0.757; 95% CI: 0.584–0.981; P=0.035) were predictors of high-grade CCC development. EOS of >0.12×109/L could independently predict high-grade CCC with 72.5% sensitivity and 58.4% specificity (area under the curve: 0.681; 95% CI: 0.632–0.729).Conclusion: EOS were associated with high-grade CCC in patients with UAP with coronary stenosis ≥80%. Increased EOS count may play an important role in the development of CCC in patients with UAP. Keywords: unstable angina pectoris, coronary collateral circulation, eosinophils, coronary artery diseaseWang JLi QLi SJWang DZChen BXDove Medical Pressarticleunstable angina pectoriscoronary collateral circulationeosinophilscoronary artery diseaseGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 105-110 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	unstable angina pectoris coronary collateral circulation eosinophils coronary artery disease Geriatrics RC952-954.6
spellingShingle	unstable angina pectoris coronary collateral circulation eosinophils coronary artery disease Geriatrics RC952-954.6 Wang J Li Q Li SJ Wang DZ Chen BX Relationship of coronary collateral circulation with eosinophils in patients with unstable angina pectoris
description	Jun Wang,1,* Qun Li,2,* Shi-jing Li,1 De-zhao Wang,2 Bu-xing Chen2 1Department of Cardiology, Beijing Mentougou District Hospital, 2Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China *These authors contributed equally to this work Background: Eosinophils (EOS) have been associated with prognosis of patients with coronary artery disease, and those who showed plenitudinous coronary collateral circulation (CCC) often have good clinical consequences. However, the relationship between EOS and CCC was seldom reported. Objective: To investigate the relationship between EOS and CCC development in patients with unstable angina pectoris (UAP).Methods: The study population consisted of 502 consecutive patients with UAP who underwent coronary angiography and coronary stenosis ≥80%. CCC was graded according to the Rentrop grading system of 0–3. Rentrop grades of 0 and 1 indicated low-grade CCC group, whereas grades 2 and 3 indicated high-grade CCC group.Results: The EOS was significantly higher in the high-grade CCC group compared with the low-grade CCC group. In multiple logistic regression analysis, EOS (odds ratio: 1.969; 95% confidence interval [CI]: 1.210–3.3205; P=0.006) and neutrophil count (odds ratio: 0.757; 95% CI: 0.584–0.981; P=0.035) were predictors of high-grade CCC development. EOS of >0.12×109/L could independently predict high-grade CCC with 72.5% sensitivity and 58.4% specificity (area under the curve: 0.681; 95% CI: 0.632–0.729).Conclusion: EOS were associated with high-grade CCC in patients with UAP with coronary stenosis ≥80%. Increased EOS count may play an important role in the development of CCC in patients with UAP. Keywords: unstable angina pectoris, coronary collateral circulation, eosinophils, coronary artery disease
format	article
author	Wang J Li Q Li SJ Wang DZ Chen BX
author_facet	Wang J Li Q Li SJ Wang DZ Chen BX
author_sort	Wang J
title	Relationship of coronary collateral circulation with eosinophils in patients with unstable angina pectoris
title_short	Relationship of coronary collateral circulation with eosinophils in patients with unstable angina pectoris
title_full	Relationship of coronary collateral circulation with eosinophils in patients with unstable angina pectoris
title_fullStr	Relationship of coronary collateral circulation with eosinophils in patients with unstable angina pectoris
title_full_unstemmed	Relationship of coronary collateral circulation with eosinophils in patients with unstable angina pectoris
title_sort	relationship of coronary collateral circulation with eosinophils in patients with unstable angina pectoris
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/738c3d60d89f48bf9d662b451bfb59b2
work_keys_str_mv	AT wangj relationshipofcoronarycollateralcirculationwitheosinophilsinpatientswithunstableanginapectoris AT liq relationshipofcoronarycollateralcirculationwitheosinophilsinpatientswithunstableanginapectoris AT lisj relationshipofcoronarycollateralcirculationwitheosinophilsinpatientswithunstableanginapectoris AT wangdz relationshipofcoronarycollateralcirculationwitheosinophilsinpatientswithunstableanginapectoris AT chenbx relationshipofcoronarycollateralcirculationwitheosinophilsinpatientswithunstableanginapectoris
_version_	1718402603337908224

Relationship of coronary collateral circulation with eosinophils in patients with unstable angina pectoris

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