Immune Cell Infiltration Analysis Demonstrates Excessive Mast Cell Activation in Psoriasis

Psoriasis represents multiple inflammatory processes and exaggerated physiological responses to epithelial damage by innate and adaptive immune components, thus it is critical to compare the immune cell niche in disease and healthy skin. Here, we inferred the proportions of different immune cell typ...

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Autores principales:	Yongjun Zhang, Yanqiang Shi, Jingxia Lin, Xuefei Li, Bin Yang, Jiajian Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	psoriasis inflammatory immune cell niche mast cell activation. Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/738c81774dd34c3e974670e83051f525
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spelling	oai:doaj.org-article:738c81774dd34c3e974670e83051f5252021-11-30T13:08:57ZImmune Cell Infiltration Analysis Demonstrates Excessive Mast Cell Activation in Psoriasis1664-322410.3389/fimmu.2021.773280https://doaj.org/article/738c81774dd34c3e974670e83051f5252021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.773280/fullhttps://doaj.org/toc/1664-3224Psoriasis represents multiple inflammatory processes and exaggerated physiological responses to epithelial damage by innate and adaptive immune components, thus it is critical to compare the immune cell niche in disease and healthy skin. Here, we inferred the proportions of different immune cell types in psoriatic and healthy skin using the CIBERSORT algorithm with expression profiles as input. As a result, we observed a dramatic change of immune cell profiles in psoriatic skin compared with healthy skin. Interestingly, the resting mast cells is almost eliminated in psoriatic skin. In contrast, the activated mast cells are enriched in psoriatic skin, indicating that mast cells activation may play an important role in psoriasis pathogenesis. In addition, we found that the proportion of the resting mast cells gradually come back to the normal level in lesioned skin upon etanercept treatment, suggesting that mast cells play a critical role in immune cell niche maintenance. Further experiments validated a significant decrease in mast cell population and an excessive mast cell activation in psoriatic skin compared with healthy skin. In conclusion, our integrative analyses of the immune cell profiles and the corresponding marker genes expression provide a better understanding of the inflammation response in psoriasis and important clues for clinical applications.Yongjun ZhangYanqiang ShiJingxia LinXuefei LiBin YangJiajian ZhouFrontiers Media S.A.articlepsoriasisinflammatoryimmune cell nichemast cellactivation.Immunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	psoriasis inflammatory immune cell niche mast cell activation. Immunologic diseases. Allergy RC581-607
spellingShingle	psoriasis inflammatory immune cell niche mast cell activation. Immunologic diseases. Allergy RC581-607 Yongjun Zhang Yanqiang Shi Jingxia Lin Xuefei Li Bin Yang Jiajian Zhou Immune Cell Infiltration Analysis Demonstrates Excessive Mast Cell Activation in Psoriasis
description	Psoriasis represents multiple inflammatory processes and exaggerated physiological responses to epithelial damage by innate and adaptive immune components, thus it is critical to compare the immune cell niche in disease and healthy skin. Here, we inferred the proportions of different immune cell types in psoriatic and healthy skin using the CIBERSORT algorithm with expression profiles as input. As a result, we observed a dramatic change of immune cell profiles in psoriatic skin compared with healthy skin. Interestingly, the resting mast cells is almost eliminated in psoriatic skin. In contrast, the activated mast cells are enriched in psoriatic skin, indicating that mast cells activation may play an important role in psoriasis pathogenesis. In addition, we found that the proportion of the resting mast cells gradually come back to the normal level in lesioned skin upon etanercept treatment, suggesting that mast cells play a critical role in immune cell niche maintenance. Further experiments validated a significant decrease in mast cell population and an excessive mast cell activation in psoriatic skin compared with healthy skin. In conclusion, our integrative analyses of the immune cell profiles and the corresponding marker genes expression provide a better understanding of the inflammation response in psoriasis and important clues for clinical applications.
format	article
author	Yongjun Zhang Yanqiang Shi Jingxia Lin Xuefei Li Bin Yang Jiajian Zhou
author_facet	Yongjun Zhang Yanqiang Shi Jingxia Lin Xuefei Li Bin Yang Jiajian Zhou
author_sort	Yongjun Zhang
title	Immune Cell Infiltration Analysis Demonstrates Excessive Mast Cell Activation in Psoriasis
title_short	Immune Cell Infiltration Analysis Demonstrates Excessive Mast Cell Activation in Psoriasis
title_full	Immune Cell Infiltration Analysis Demonstrates Excessive Mast Cell Activation in Psoriasis
title_fullStr	Immune Cell Infiltration Analysis Demonstrates Excessive Mast Cell Activation in Psoriasis
title_full_unstemmed	Immune Cell Infiltration Analysis Demonstrates Excessive Mast Cell Activation in Psoriasis
title_sort	immune cell infiltration analysis demonstrates excessive mast cell activation in psoriasis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/738c81774dd34c3e974670e83051f525
work_keys_str_mv	AT yongjunzhang immunecellinfiltrationanalysisdemonstratesexcessivemastcellactivationinpsoriasis AT yanqiangshi immunecellinfiltrationanalysisdemonstratesexcessivemastcellactivationinpsoriasis AT jingxialin immunecellinfiltrationanalysisdemonstratesexcessivemastcellactivationinpsoriasis AT xuefeili immunecellinfiltrationanalysisdemonstratesexcessivemastcellactivationinpsoriasis AT binyang immunecellinfiltrationanalysisdemonstratesexcessivemastcellactivationinpsoriasis AT jiajianzhou immunecellinfiltrationanalysisdemonstratesexcessivemastcellactivationinpsoriasis
_version_	1718406569900638208

Immune Cell Infiltration Analysis Demonstrates Excessive Mast Cell Activation in Psoriasis

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