Brain-Derived Neurotrophic Factor, Neutrophils and Cysteinyl Leukotriene Receptor 1 as Potential Prognostic Biomarkers for Patients with Colon Cancer

The tumor microenvironment has been recognized as a complex network in which immune cells play an important role in cancer progression. We found significantly higher CD66b neutrophil expression in tumor tissue than in matched normal mucosa in the Malmö colon cancer (CC) cohort and poorer survival of...

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Autores principales:	Syrina F. Mehrabi, Souvik Ghatak, Lubna M. Mehdawi, Geriolda Topi, Shakti Ranjan Satapathy, Anita Sjölander
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	BDNF LTD<sub>4</sub> CysLT<sub>1</sub> montelukast neutrophils colon cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/73906e63c76643929561493ea61ae8b3
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spelling	oai:doaj.org-article:73906e63c76643929561493ea61ae8b32021-11-11T15:33:50ZBrain-Derived Neurotrophic Factor, Neutrophils and Cysteinyl Leukotriene Receptor 1 as Potential Prognostic Biomarkers for Patients with Colon Cancer10.3390/cancers132155202072-6694https://doaj.org/article/73906e63c76643929561493ea61ae8b32021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5520https://doaj.org/toc/2072-6694The tumor microenvironment has been recognized as a complex network in which immune cells play an important role in cancer progression. We found significantly higher CD66b neutrophil expression in tumor tissue than in matched normal mucosa in the Malmö colon cancer (CC) cohort and poorer survival of stage I-III patients with high CD66b expression. Additionally, mice lacking CysLT<sub>1</sub>R expression (<i>cysltr1<sup>−/−</sup></i>) produce less brain-derived neurotrophic factor (BDNF) compared to WT mice and Montelukast (a CysLT<sub>1</sub>R antagonist)-treated mice also reduced BDNF expression in a mouse xenograft model with human SW480 CC cells. CD66b and BDNF expression was significantly higher in patient tumor tissues than in the matched normal mucosa. The univariate Cox PH analysis yielded CD66b and BDNF as an independent predictor of overall survival, which was also found in the public TCGA-COAD dataset. We also discovered a strong positive correlation between CD66b, BDNF and CysLT<sub>1</sub>R expression in the Malmö CC cohort and in the TCGA-COAD dataset. Our data suggest that CD66b/BDNF/CysLT<sub>1</sub>R expression as a prognostic combined biomarker signature for CC patients.Syrina F. MehrabiSouvik GhatakLubna M. MehdawiGeriolda TopiShakti Ranjan SatapathyAnita SjölanderMDPI AGarticleBDNFLTD<sub>4</sub>CysLT<sub>1</sub>montelukastneutrophilscolon cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5520, p 5520 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	BDNF LTD<sub>4</sub> CysLT<sub>1</sub> montelukast neutrophils colon cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	BDNF LTD<sub>4</sub> CysLT<sub>1</sub> montelukast neutrophils colon cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Syrina F. Mehrabi Souvik Ghatak Lubna M. Mehdawi Geriolda Topi Shakti Ranjan Satapathy Anita Sjölander Brain-Derived Neurotrophic Factor, Neutrophils and Cysteinyl Leukotriene Receptor 1 as Potential Prognostic Biomarkers for Patients with Colon Cancer
description	The tumor microenvironment has been recognized as a complex network in which immune cells play an important role in cancer progression. We found significantly higher CD66b neutrophil expression in tumor tissue than in matched normal mucosa in the Malmö colon cancer (CC) cohort and poorer survival of stage I-III patients with high CD66b expression. Additionally, mice lacking CysLT<sub>1</sub>R expression (<i>cysltr1<sup>−/−</sup></i>) produce less brain-derived neurotrophic factor (BDNF) compared to WT mice and Montelukast (a CysLT<sub>1</sub>R antagonist)-treated mice also reduced BDNF expression in a mouse xenograft model with human SW480 CC cells. CD66b and BDNF expression was significantly higher in patient tumor tissues than in the matched normal mucosa. The univariate Cox PH analysis yielded CD66b and BDNF as an independent predictor of overall survival, which was also found in the public TCGA-COAD dataset. We also discovered a strong positive correlation between CD66b, BDNF and CysLT<sub>1</sub>R expression in the Malmö CC cohort and in the TCGA-COAD dataset. Our data suggest that CD66b/BDNF/CysLT<sub>1</sub>R expression as a prognostic combined biomarker signature for CC patients.
format	article
author	Syrina F. Mehrabi Souvik Ghatak Lubna M. Mehdawi Geriolda Topi Shakti Ranjan Satapathy Anita Sjölander
author_facet	Syrina F. Mehrabi Souvik Ghatak Lubna M. Mehdawi Geriolda Topi Shakti Ranjan Satapathy Anita Sjölander
author_sort	Syrina F. Mehrabi
title	Brain-Derived Neurotrophic Factor, Neutrophils and Cysteinyl Leukotriene Receptor 1 as Potential Prognostic Biomarkers for Patients with Colon Cancer
title_short	Brain-Derived Neurotrophic Factor, Neutrophils and Cysteinyl Leukotriene Receptor 1 as Potential Prognostic Biomarkers for Patients with Colon Cancer
title_full	Brain-Derived Neurotrophic Factor, Neutrophils and Cysteinyl Leukotriene Receptor 1 as Potential Prognostic Biomarkers for Patients with Colon Cancer
title_fullStr	Brain-Derived Neurotrophic Factor, Neutrophils and Cysteinyl Leukotriene Receptor 1 as Potential Prognostic Biomarkers for Patients with Colon Cancer
title_full_unstemmed	Brain-Derived Neurotrophic Factor, Neutrophils and Cysteinyl Leukotriene Receptor 1 as Potential Prognostic Biomarkers for Patients with Colon Cancer
title_sort	brain-derived neurotrophic factor, neutrophils and cysteinyl leukotriene receptor 1 as potential prognostic biomarkers for patients with colon cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/73906e63c76643929561493ea61ae8b3
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Brain-Derived Neurotrophic Factor, Neutrophils and Cysteinyl Leukotriene Receptor 1 as Potential Prognostic Biomarkers for Patients with Colon Cancer

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