Novel cancer stem cell marker MVP enhances temozolomide-resistance in glioblastoma

The resistance of highly aggressive glioblastoma multiforme (GBM) to chemotherapy is a major clinical problem resulting in a poor prognosis. GBM contains a rare population of self-renewing cancer stem cells (CSCs) that proliferate, spurring the growth of new tumors, and evade chemotherapy. In cancer...

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Autores principales:	Kum Hee Noh, Song-Hee Lee, Haeri Lee, Ae Jin Jeong, Kyu Oh Kim, Hyun Mu Shin, Hang-Rae Kim, Myung-Jin Park, Jong Bae Park, Jiyoung Lee, Sang-Kyu Ye
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Cancer stem cells Glioblastoma Major vault protein Tumorsphere Temozolomide Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7393f4778934404fa599493d9bbbd6d4
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spelling	oai:doaj.org-article:7393f4778934404fa599493d9bbbd6d42021-11-04T04:28:02ZNovel cancer stem cell marker MVP enhances temozolomide-resistance in glioblastoma1936-523310.1016/j.tranon.2021.101255https://doaj.org/article/7393f4778934404fa599493d9bbbd6d42022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1936523321002448https://doaj.org/toc/1936-5233The resistance of highly aggressive glioblastoma multiforme (GBM) to chemotherapy is a major clinical problem resulting in a poor prognosis. GBM contains a rare population of self-renewing cancer stem cells (CSCs) that proliferate, spurring the growth of new tumors, and evade chemotherapy. In cancer, major vault protein (MVP) is thought to contribute to drug resistance. However, the role of MVP as CSCs marker remains unknown and whether MVP could sensitize GBM cells to Temozolomide (TMZ) also is unclear. We found that sensitivity to TMZ was suppressed by significantly increasing the MVP expression in GBM cells with TMZ resistance. Also, MVP was associated with the expression of other multidrug-resistant proteins in tumorsphere of TMZ-resistant GBM cell, and was highly co-expressed with CSC markers in tumorsphere culture. On the other hands, knockdown of MVP resulted in reduced sphere formation and invasive capacity. Moreover, high expression of MVP was associated with tumor malignancy and survival rate in glioblastoma patients. Our study describes that MVP is a potentially novel maker for glioblastoma stem cells and may be useful as a target for preventing TMZ resistance in GBM patients.Kum Hee NohSong-Hee LeeHaeri LeeAe Jin JeongKyu Oh KimHyun Mu ShinHang-Rae KimMyung-Jin ParkJong Bae ParkJiyoung LeeSang-Kyu YeElsevierarticleCancer stem cellsGlioblastomaMajor vault proteinTumorsphereTemozolomideNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENTranslational Oncology, Vol 15, Iss 1, Pp 101255- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cancer stem cells Glioblastoma Major vault protein Tumorsphere Temozolomide Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Cancer stem cells Glioblastoma Major vault protein Tumorsphere Temozolomide Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Kum Hee Noh Song-Hee Lee Haeri Lee Ae Jin Jeong Kyu Oh Kim Hyun Mu Shin Hang-Rae Kim Myung-Jin Park Jong Bae Park Jiyoung Lee Sang-Kyu Ye Novel cancer stem cell marker MVP enhances temozolomide-resistance in glioblastoma
description	The resistance of highly aggressive glioblastoma multiforme (GBM) to chemotherapy is a major clinical problem resulting in a poor prognosis. GBM contains a rare population of self-renewing cancer stem cells (CSCs) that proliferate, spurring the growth of new tumors, and evade chemotherapy. In cancer, major vault protein (MVP) is thought to contribute to drug resistance. However, the role of MVP as CSCs marker remains unknown and whether MVP could sensitize GBM cells to Temozolomide (TMZ) also is unclear. We found that sensitivity to TMZ was suppressed by significantly increasing the MVP expression in GBM cells with TMZ resistance. Also, MVP was associated with the expression of other multidrug-resistant proteins in tumorsphere of TMZ-resistant GBM cell, and was highly co-expressed with CSC markers in tumorsphere culture. On the other hands, knockdown of MVP resulted in reduced sphere formation and invasive capacity. Moreover, high expression of MVP was associated with tumor malignancy and survival rate in glioblastoma patients. Our study describes that MVP is a potentially novel maker for glioblastoma stem cells and may be useful as a target for preventing TMZ resistance in GBM patients.
format	article
author	Kum Hee Noh Song-Hee Lee Haeri Lee Ae Jin Jeong Kyu Oh Kim Hyun Mu Shin Hang-Rae Kim Myung-Jin Park Jong Bae Park Jiyoung Lee Sang-Kyu Ye
author_facet	Kum Hee Noh Song-Hee Lee Haeri Lee Ae Jin Jeong Kyu Oh Kim Hyun Mu Shin Hang-Rae Kim Myung-Jin Park Jong Bae Park Jiyoung Lee Sang-Kyu Ye
author_sort	Kum Hee Noh
title	Novel cancer stem cell marker MVP enhances temozolomide-resistance in glioblastoma
title_short	Novel cancer stem cell marker MVP enhances temozolomide-resistance in glioblastoma
title_full	Novel cancer stem cell marker MVP enhances temozolomide-resistance in glioblastoma
title_fullStr	Novel cancer stem cell marker MVP enhances temozolomide-resistance in glioblastoma
title_full_unstemmed	Novel cancer stem cell marker MVP enhances temozolomide-resistance in glioblastoma
title_sort	novel cancer stem cell marker mvp enhances temozolomide-resistance in glioblastoma
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/7393f4778934404fa599493d9bbbd6d4
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Novel cancer stem cell marker MVP enhances temozolomide-resistance in glioblastoma

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