Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations

Somatic and germline mutations are found at different densities across the genome. Here, the authors compare human somatic tumour mutations with the germline of humans, chimpanzees, and gorillas, and find that the mutation density of tumours correlates better with non-human great apes than with the...

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Autores principales: José María Heredia-Genestar, Tomàs Marquès-Bonet, David Juan, Arcadi Navarro
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/73956e4b69204f6f98cdc12093e6eea7
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spelling oai:doaj.org-article:73956e4b69204f6f98cdc12093e6eea72021-12-02T14:58:51ZExtreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations10.1038/s41467-020-16296-42041-1723https://doaj.org/article/73956e4b69204f6f98cdc12093e6eea72020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16296-4https://doaj.org/toc/2041-1723Somatic and germline mutations are found at different densities across the genome. Here, the authors compare human somatic tumour mutations with the germline of humans, chimpanzees, and gorillas, and find that the mutation density of tumours correlates better with non-human great apes than with the human germline.José María Heredia-GenestarTomàs Marquès-BonetDavid JuanArcadi NavarroNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
José María Heredia-Genestar
Tomàs Marquès-Bonet
David Juan
Arcadi Navarro
Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations
description Somatic and germline mutations are found at different densities across the genome. Here, the authors compare human somatic tumour mutations with the germline of humans, chimpanzees, and gorillas, and find that the mutation density of tumours correlates better with non-human great apes than with the human germline.
format article
author José María Heredia-Genestar
Tomàs Marquès-Bonet
David Juan
Arcadi Navarro
author_facet José María Heredia-Genestar
Tomàs Marquès-Bonet
David Juan
Arcadi Navarro
author_sort José María Heredia-Genestar
title Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations
title_short Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations
title_full Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations
title_fullStr Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations
title_full_unstemmed Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations
title_sort extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/73956e4b69204f6f98cdc12093e6eea7
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AT davidjuan extremedifferencesbetweenhumangermlineandtumormutationdensitiesaredrivenbyancestralhumanspecificdeviations
AT arcadinavarro extremedifferencesbetweenhumangermlineandtumormutationdensitiesaredrivenbyancestralhumanspecificdeviations
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