Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations
Somatic and germline mutations are found at different densities across the genome. Here, the authors compare human somatic tumour mutations with the germline of humans, chimpanzees, and gorillas, and find that the mutation density of tumours correlates better with non-human great apes than with the...
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Nature Portfolio
2020
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oai:doaj.org-article:73956e4b69204f6f98cdc12093e6eea72021-12-02T14:58:51ZExtreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations10.1038/s41467-020-16296-42041-1723https://doaj.org/article/73956e4b69204f6f98cdc12093e6eea72020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16296-4https://doaj.org/toc/2041-1723Somatic and germline mutations are found at different densities across the genome. Here, the authors compare human somatic tumour mutations with the germline of humans, chimpanzees, and gorillas, and find that the mutation density of tumours correlates better with non-human great apes than with the human germline.José María Heredia-GenestarTomàs Marquès-BonetDavid JuanArcadi NavarroNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020) |
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Science Q José María Heredia-Genestar Tomàs Marquès-Bonet David Juan Arcadi Navarro Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations |
description |
Somatic and germline mutations are found at different densities across the genome. Here, the authors compare human somatic tumour mutations with the germline of humans, chimpanzees, and gorillas, and find that the mutation density of tumours correlates better with non-human great apes than with the human germline. |
format |
article |
author |
José María Heredia-Genestar Tomàs Marquès-Bonet David Juan Arcadi Navarro |
author_facet |
José María Heredia-Genestar Tomàs Marquès-Bonet David Juan Arcadi Navarro |
author_sort |
José María Heredia-Genestar |
title |
Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations |
title_short |
Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations |
title_full |
Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations |
title_fullStr |
Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations |
title_full_unstemmed |
Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations |
title_sort |
extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/73956e4b69204f6f98cdc12093e6eea7 |
work_keys_str_mv |
AT josemariaherediagenestar extremedifferencesbetweenhumangermlineandtumormutationdensitiesaredrivenbyancestralhumanspecificdeviations AT tomasmarquesbonet extremedifferencesbetweenhumangermlineandtumormutationdensitiesaredrivenbyancestralhumanspecificdeviations AT davidjuan extremedifferencesbetweenhumangermlineandtumormutationdensitiesaredrivenbyancestralhumanspecificdeviations AT arcadinavarro extremedifferencesbetweenhumangermlineandtumormutationdensitiesaredrivenbyancestralhumanspecificdeviations |
_version_ |
1718389272522784768 |