Synthesis and antimalarial activity of some triphenyltin(IV) aminobenzoate compounds against Plasmodium falciparum

This paper presents antimalarial activity of several triphenyltin(IV) aminobenzoate compounds synthesized from the reaction of triphenyltin(IV) hydroxide with 2-, 3-, and 4-aminobenzoic acid. The activity of the compounds as anti-malaria agents was evaluated using Plasmodium falciparum, and demonstr...

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Autores principales:	Hadi Sutopo, Fenska Mona Dwi, Noviany Noviany, Satria Heri, Simanjuntak Wasinton, Naseer Muhammad Moazzam
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	antimalarial activity ic50 triphenyltin(iv) aminobenzoate p. falciparum Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/7397988e467143d99dfd56a7fdd032b1
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spelling	oai:doaj.org-article:7397988e467143d99dfd56a7fdd032b12021-12-05T14:10:56ZSynthesis and antimalarial activity of some triphenyltin(IV) aminobenzoate compounds against Plasmodium falciparum0792-12412191-021910.1515/mgmc-2021-0028https://doaj.org/article/7397988e467143d99dfd56a7fdd032b12021-09-01T00:00:00Zhttps://doi.org/10.1515/mgmc-2021-0028https://doaj.org/toc/0792-1241https://doaj.org/toc/2191-0219This paper presents antimalarial activity of several triphenyltin(IV) aminobenzoate compounds synthesized from the reaction of triphenyltin(IV) hydroxide with 2-, 3-, and 4-aminobenzoic acid. The activity of the compounds as anti-malaria agents was evaluated using Plasmodium falciparum, and demonstrated that the compounds have about the same IC50 with that of chloroquine (2×10−3 μg/mL) applied as the positive control. The result also showed that the Plasmodium is non-resistent to the compounds synthesized, which is the opposite to chloroquine.Hadi SutopoFenska Mona DwiNoviany NovianySatria HeriSimanjuntak WasintonNaseer Muhammad MoazzamDe Gruyterarticleantimalarial activityic50triphenyltin(iv) aminobenzoatep. falciparumChemistryQD1-999ENMain Group Metal Chemistry, Vol 44, Iss 1, Pp 256-260 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antimalarial activity ic50 triphenyltin(iv) aminobenzoate p. falciparum Chemistry QD1-999
spellingShingle	antimalarial activity ic50 triphenyltin(iv) aminobenzoate p. falciparum Chemistry QD1-999 Hadi Sutopo Fenska Mona Dwi Noviany Noviany Satria Heri Simanjuntak Wasinton Naseer Muhammad Moazzam Synthesis and antimalarial activity of some triphenyltin(IV) aminobenzoate compounds against Plasmodium falciparum
description	This paper presents antimalarial activity of several triphenyltin(IV) aminobenzoate compounds synthesized from the reaction of triphenyltin(IV) hydroxide with 2-, 3-, and 4-aminobenzoic acid. The activity of the compounds as anti-malaria agents was evaluated using Plasmodium falciparum, and demonstrated that the compounds have about the same IC50 with that of chloroquine (2×10−3 μg/mL) applied as the positive control. The result also showed that the Plasmodium is non-resistent to the compounds synthesized, which is the opposite to chloroquine.
format	article
author	Hadi Sutopo Fenska Mona Dwi Noviany Noviany Satria Heri Simanjuntak Wasinton Naseer Muhammad Moazzam
author_facet	Hadi Sutopo Fenska Mona Dwi Noviany Noviany Satria Heri Simanjuntak Wasinton Naseer Muhammad Moazzam
author_sort	Hadi Sutopo
title	Synthesis and antimalarial activity of some triphenyltin(IV) aminobenzoate compounds against Plasmodium falciparum
title_short	Synthesis and antimalarial activity of some triphenyltin(IV) aminobenzoate compounds against Plasmodium falciparum
title_full	Synthesis and antimalarial activity of some triphenyltin(IV) aminobenzoate compounds against Plasmodium falciparum
title_fullStr	Synthesis and antimalarial activity of some triphenyltin(IV) aminobenzoate compounds against Plasmodium falciparum
title_full_unstemmed	Synthesis and antimalarial activity of some triphenyltin(IV) aminobenzoate compounds against Plasmodium falciparum
title_sort	synthesis and antimalarial activity of some triphenyltin(iv) aminobenzoate compounds against plasmodium falciparum
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/7397988e467143d99dfd56a7fdd032b1
work_keys_str_mv	AT hadisutopo synthesisandantimalarialactivityofsometriphenyltinivaminobenzoatecompoundsagainstplasmodiumfalciparum AT fenskamonadwi synthesisandantimalarialactivityofsometriphenyltinivaminobenzoatecompoundsagainstplasmodiumfalciparum AT novianynoviany synthesisandantimalarialactivityofsometriphenyltinivaminobenzoatecompoundsagainstplasmodiumfalciparum AT satriaheri synthesisandantimalarialactivityofsometriphenyltinivaminobenzoatecompoundsagainstplasmodiumfalciparum AT simanjuntakwasinton synthesisandantimalarialactivityofsometriphenyltinivaminobenzoatecompoundsagainstplasmodiumfalciparum AT naseermuhammadmoazzam synthesisandantimalarialactivityofsometriphenyltinivaminobenzoatecompoundsagainstplasmodiumfalciparum
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Synthesis and antimalarial activity of some triphenyltin(IV) aminobenzoate compounds against Plasmodium falciparum

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