Mapping brain response to pain in fibromyalgia patients using temporal analysis of FMRI.

<h4>Background</h4>Nociceptive stimuli may evoke brain responses longer than the stimulus duration often partially detected by conventional neuroimaging. Fibromyalgia patients typically complain of severe pain from gentle stimuli. We aimed to characterize brain response to painful pressu...

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Autores principales:	Jesus Pujol, Marina López-Solà, Héctor Ortiz, Joan Carles Vilanova, Ben J Harrison, Murat Yücel, Carles Soriano-Mas, Narcís Cardoner, Joan Deus
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/739a474db2aa4443a4348df8dd1454d0
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spelling	oai:doaj.org-article:739a474db2aa4443a4348df8dd1454d02021-11-25T06:16:04ZMapping brain response to pain in fibromyalgia patients using temporal analysis of FMRI.1932-620310.1371/journal.pone.0005224https://doaj.org/article/739a474db2aa4443a4348df8dd1454d02009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19381292/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Nociceptive stimuli may evoke brain responses longer than the stimulus duration often partially detected by conventional neuroimaging. Fibromyalgia patients typically complain of severe pain from gentle stimuli. We aimed to characterize brain response to painful pressure in fibromyalgia patients by generating activation maps adjusted for the duration of brain responses.<h4>Methodology/principal findings</h4>Twenty-seven women (mean age: 47.8 years) were assessed with fMRI. The sample included nine fibromyalgia patients and nine healthy subjects who received 4 kg/cm(2) of pressure on the thumb. Nine additional control subjects received 6.8 kg/cm(2) to match the patients for the severity of perceived pain. Independent Component Analysis characterized the temporal dynamics of the actual brain response to pressure. Statistical parametric maps were estimated using the obtained time courses. Brain response to pressure (18 seconds) consistently exceeded the stimulus application (9 seconds) in somatosensory regions in all groups. fMRI maps following such temporal dynamics showed a complete pain network response (sensory-motor cortices, operculo-insula, cingulate cortex, and basal ganglia) to 4 kg/cm(2) of pressure in fibromyalgia patients. In healthy subjects, response to this low intensity pressure involved mainly somatosensory cortices. When matched for perceived pain (6.8 kg/cm(2)), control subjects showed also comprehensive activation of pain-related regions, but fibromyalgia patients showed significantly larger activation in the anterior insula-basal ganglia complex and the cingulate cortex.<h4>Conclusions/significance</h4>The results suggest that data-driven fMRI assessments may complement conventional neuroimaging for characterizing pain responses and that enhancement of brain activation in fibromyalgia patients may be particularly relevant in emotion-related regions.Jesus PujolMarina López-SolàHéctor OrtizJoan Carles VilanovaBen J HarrisonMurat YücelCarles Soriano-MasNarcís CardonerJoan DeusPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 4, p e5224 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jesus Pujol Marina López-Solà Héctor Ortiz Joan Carles Vilanova Ben J Harrison Murat Yücel Carles Soriano-Mas Narcís Cardoner Joan Deus Mapping brain response to pain in fibromyalgia patients using temporal analysis of FMRI.
description	<h4>Background</h4>Nociceptive stimuli may evoke brain responses longer than the stimulus duration often partially detected by conventional neuroimaging. Fibromyalgia patients typically complain of severe pain from gentle stimuli. We aimed to characterize brain response to painful pressure in fibromyalgia patients by generating activation maps adjusted for the duration of brain responses.<h4>Methodology/principal findings</h4>Twenty-seven women (mean age: 47.8 years) were assessed with fMRI. The sample included nine fibromyalgia patients and nine healthy subjects who received 4 kg/cm(2) of pressure on the thumb. Nine additional control subjects received 6.8 kg/cm(2) to match the patients for the severity of perceived pain. Independent Component Analysis characterized the temporal dynamics of the actual brain response to pressure. Statistical parametric maps were estimated using the obtained time courses. Brain response to pressure (18 seconds) consistently exceeded the stimulus application (9 seconds) in somatosensory regions in all groups. fMRI maps following such temporal dynamics showed a complete pain network response (sensory-motor cortices, operculo-insula, cingulate cortex, and basal ganglia) to 4 kg/cm(2) of pressure in fibromyalgia patients. In healthy subjects, response to this low intensity pressure involved mainly somatosensory cortices. When matched for perceived pain (6.8 kg/cm(2)), control subjects showed also comprehensive activation of pain-related regions, but fibromyalgia patients showed significantly larger activation in the anterior insula-basal ganglia complex and the cingulate cortex.<h4>Conclusions/significance</h4>The results suggest that data-driven fMRI assessments may complement conventional neuroimaging for characterizing pain responses and that enhancement of brain activation in fibromyalgia patients may be particularly relevant in emotion-related regions.
format	article
author	Jesus Pujol Marina López-Solà Héctor Ortiz Joan Carles Vilanova Ben J Harrison Murat Yücel Carles Soriano-Mas Narcís Cardoner Joan Deus
author_facet	Jesus Pujol Marina López-Solà Héctor Ortiz Joan Carles Vilanova Ben J Harrison Murat Yücel Carles Soriano-Mas Narcís Cardoner Joan Deus
author_sort	Jesus Pujol
title	Mapping brain response to pain in fibromyalgia patients using temporal analysis of FMRI.
title_short	Mapping brain response to pain in fibromyalgia patients using temporal analysis of FMRI.
title_full	Mapping brain response to pain in fibromyalgia patients using temporal analysis of FMRI.
title_fullStr	Mapping brain response to pain in fibromyalgia patients using temporal analysis of FMRI.
title_full_unstemmed	Mapping brain response to pain in fibromyalgia patients using temporal analysis of FMRI.
title_sort	mapping brain response to pain in fibromyalgia patients using temporal analysis of fmri.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/739a474db2aa4443a4348df8dd1454d0
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Mapping brain response to pain in fibromyalgia patients using temporal analysis of FMRI.

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