Early Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases

Background: Squamous cell carcinoma (SCC) may present with perineural invasion (PNI). Objective: To investigate the characteristics of early invasive SCC with or without PNI. Methods: Consecutive SCC excisions were prospectively reviewed from a single Australian community-based practice for 2...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	John H. Pyne, Esther Myint, Simon P. Clark, Maddie Gorji, Ruihang Hou
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2020
Materias:	squamous cell carcinoma perineurial invasion grade of differentiation invasion depth anatomic site Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/739e4ce26a574b6f80d04c0ad2bdbd87
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:739e4ce26a574b6f80d04c0ad2bdbd87
record_format	dspace
spelling	oai:doaj.org-article:739e4ce26a574b6f80d04c0ad2bdbd872021-11-17T08:28:43ZEarly Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases10.5826/dpc.1003a592160-9381https://doaj.org/article/739e4ce26a574b6f80d04c0ad2bdbd872020-06-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/1116https://doaj.org/toc/2160-9381 Background: Squamous cell carcinoma (SCC) may present with perineural invasion (PNI). Objective: To investigate the characteristics of early invasive SCC with or without PNI. Methods: Consecutive SCC excisions were prospectively reviewed from a single Australian community-based practice for 2016-2018. Tumor characteristics recorded were anatomic site, maximum microscopic tumor surface diameter, invasion depth, grade of differentiation, and diameter of nerves with PNI. Results: In total, 1,772 cases were collected. No PNI cases were found on female patients. Seven of the total 10 PNI cases were on facial sites. Maximum average microscopic tumor surface diameters ranged from 10.1 mm (well differentiated) up to 11.0 mm (moderately differentiated). Maximum average invasion depths by differentiation ranged from 1.7 (well differentiated) up to 2.6 mm (poorly differentiated). The PNI cases were as follows: well differentiated (n = 0), moderately differentiated (n = 4), or poorly differentiated (n = 6). Minimum average histopathological margins for well, moderately, and poorly differentiated SCC, respectively, were 1.4, 1.1, and 1.3 mm. Minimum microscopic tumor surface diameters for PNI cases were 7 mm for moderately and 5 mm for poorly differentiated SCC. Minimum microscopic invasion depths for PNI cases were 2.2 mm for moderate and 0.9 mm for poor differentiation. Conclusions: We found early SCC with PNI displayed nerve diameters of 0.1 mm or less and were exclusively on male patients aged 60 or older, on chronically sun-exposed sites of the head and upper midline anterior chest. Histopathological features associated with PNI were moderate and poor differentiation, tumor invasion beyond 0.9 mm, and adjacent lymphocytosis. John H. PyneEsther MyintSimon P. ClarkMaddie GorjiRuihang HouMattioli1885articlesquamous cell carcinomaperineurial invasiongrade of differentiationinvasion depthanatomic siteDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 10, Iss 3 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	squamous cell carcinoma perineurial invasion grade of differentiation invasion depth anatomic site Dermatology RL1-803
spellingShingle	squamous cell carcinoma perineurial invasion grade of differentiation invasion depth anatomic site Dermatology RL1-803 John H. Pyne Esther Myint Simon P. Clark Maddie Gorji Ruihang Hou Early Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases
description	Background: Squamous cell carcinoma (SCC) may present with perineural invasion (PNI). Objective: To investigate the characteristics of early invasive SCC with or without PNI. Methods: Consecutive SCC excisions were prospectively reviewed from a single Australian community-based practice for 2016-2018. Tumor characteristics recorded were anatomic site, maximum microscopic tumor surface diameter, invasion depth, grade of differentiation, and diameter of nerves with PNI. Results: In total, 1,772 cases were collected. No PNI cases were found on female patients. Seven of the total 10 PNI cases were on facial sites. Maximum average microscopic tumor surface diameters ranged from 10.1 mm (well differentiated) up to 11.0 mm (moderately differentiated). Maximum average invasion depths by differentiation ranged from 1.7 (well differentiated) up to 2.6 mm (poorly differentiated). The PNI cases were as follows: well differentiated (n = 0), moderately differentiated (n = 4), or poorly differentiated (n = 6). Minimum average histopathological margins for well, moderately, and poorly differentiated SCC, respectively, were 1.4, 1.1, and 1.3 mm. Minimum microscopic tumor surface diameters for PNI cases were 7 mm for moderately and 5 mm for poorly differentiated SCC. Minimum microscopic invasion depths for PNI cases were 2.2 mm for moderate and 0.9 mm for poor differentiation. Conclusions: We found early SCC with PNI displayed nerve diameters of 0.1 mm or less and were exclusively on male patients aged 60 or older, on chronically sun-exposed sites of the head and upper midline anterior chest. Histopathological features associated with PNI were moderate and poor differentiation, tumor invasion beyond 0.9 mm, and adjacent lymphocytosis.
format	article
author	John H. Pyne Esther Myint Simon P. Clark Maddie Gorji Ruihang Hou
author_facet	John H. Pyne Esther Myint Simon P. Clark Maddie Gorji Ruihang Hou
author_sort	John H. Pyne
title	Early Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases
title_short	Early Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases
title_full	Early Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases
title_fullStr	Early Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases
title_full_unstemmed	Early Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases
title_sort	early squamous cell carcinoma with perineural invasion: a prospective study examining anatomic site, tumor surface diameter, invasion depth, and grade of differentiation in 1,772 consecutive cases
publisher	Mattioli1885
publishDate	2020
url	https://doaj.org/article/739e4ce26a574b6f80d04c0ad2bdbd87
work_keys_str_mv	AT johnhpyne earlysquamouscellcarcinomawithperineuralinvasionaprospectivestudyexamininganatomicsitetumorsurfacediameterinvasiondepthandgradeofdifferentiationin1772consecutivecases AT esthermyint earlysquamouscellcarcinomawithperineuralinvasionaprospectivestudyexamininganatomicsitetumorsurfacediameterinvasiondepthandgradeofdifferentiationin1772consecutivecases AT simonpclark earlysquamouscellcarcinomawithperineuralinvasionaprospectivestudyexamininganatomicsitetumorsurfacediameterinvasiondepthandgradeofdifferentiationin1772consecutivecases AT maddiegorji earlysquamouscellcarcinomawithperineuralinvasionaprospectivestudyexamininganatomicsitetumorsurfacediameterinvasiondepthandgradeofdifferentiationin1772consecutivecases AT ruihanghou earlysquamouscellcarcinomawithperineuralinvasionaprospectivestudyexamininganatomicsitetumorsurfacediameterinvasiondepthandgradeofdifferentiationin1772consecutivecases
_version_	1718425805215760384

Early Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases

Ejemplares similares