Strategies to Modulate the Redifferentiation of Chondrocytes
Because of the low self-healing capacity of articular cartilage, cartilage injuries and degenerations triggered by various diseases are almost irreversible. Previous studies have suggested that human chondrocytes cultured in vitro tend to dedifferentiate during the cell-amplification phase and lose...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:73a0ca65e44147a99d126dd5e83eab832021-11-22T06:41:17ZStrategies to Modulate the Redifferentiation of Chondrocytes2296-418510.3389/fbioe.2021.764193https://doaj.org/article/73a0ca65e44147a99d126dd5e83eab832021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.764193/fullhttps://doaj.org/toc/2296-4185Because of the low self-healing capacity of articular cartilage, cartilage injuries and degenerations triggered by various diseases are almost irreversible. Previous studies have suggested that human chondrocytes cultured in vitro tend to dedifferentiate during the cell-amplification phase and lose the physiological properties and functions of the cartilage itself, which is currently a critical limitation in the cultivation of cartilage for tissue engineering. Recently, numerous studies have focused on the modulation of chondrocyte redifferentiation. Researchers discovered the effect of various conditions (extracellular environment, cell sources, growth factors and redifferentiation inducers, and gene silencing and overexpression) on the redifferentiation of chondrocytes during the in vitro expansion of cells, and obtained cartilage tissue cultured in vitro that exhibited physiological characteristics and functions that were similar to those of human cartilage tissue. Encouragingly, several studies reported positive results regarding the modulation of the redifferentiation of chondrocytes in specific conditions. Here, the various factors and conditions that modulate the redifferentiation of chondrocytes, as well as their limitations and potential applications and challenges are reviewed. We expect to inspire research in the field of cartilage repair toward the future treatment of arthropathy.Xiaoshen HuWeiyang ZhangXiang LiDongling ZhongYuxi LiJuan LiRongjiang JinFrontiers Media S.A.articlechondrocytesredifferentiationdedifferentiationcartilage tissue engineeringarthropathyBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
chondrocytes redifferentiation dedifferentiation cartilage tissue engineering arthropathy Biotechnology TP248.13-248.65 |
| spellingShingle |
chondrocytes redifferentiation dedifferentiation cartilage tissue engineering arthropathy Biotechnology TP248.13-248.65 Xiaoshen Hu Weiyang Zhang Xiang Li Dongling Zhong Yuxi Li Juan Li Rongjiang Jin Strategies to Modulate the Redifferentiation of Chondrocytes |
| description |
Because of the low self-healing capacity of articular cartilage, cartilage injuries and degenerations triggered by various diseases are almost irreversible. Previous studies have suggested that human chondrocytes cultured in vitro tend to dedifferentiate during the cell-amplification phase and lose the physiological properties and functions of the cartilage itself, which is currently a critical limitation in the cultivation of cartilage for tissue engineering. Recently, numerous studies have focused on the modulation of chondrocyte redifferentiation. Researchers discovered the effect of various conditions (extracellular environment, cell sources, growth factors and redifferentiation inducers, and gene silencing and overexpression) on the redifferentiation of chondrocytes during the in vitro expansion of cells, and obtained cartilage tissue cultured in vitro that exhibited physiological characteristics and functions that were similar to those of human cartilage tissue. Encouragingly, several studies reported positive results regarding the modulation of the redifferentiation of chondrocytes in specific conditions. Here, the various factors and conditions that modulate the redifferentiation of chondrocytes, as well as their limitations and potential applications and challenges are reviewed. We expect to inspire research in the field of cartilage repair toward the future treatment of arthropathy. |
| format |
article |
| author |
Xiaoshen Hu Weiyang Zhang Xiang Li Dongling Zhong Yuxi Li Juan Li Rongjiang Jin |
| author_facet |
Xiaoshen Hu Weiyang Zhang Xiang Li Dongling Zhong Yuxi Li Juan Li Rongjiang Jin |
| author_sort |
Xiaoshen Hu |
| title |
Strategies to Modulate the Redifferentiation of Chondrocytes |
| title_short |
Strategies to Modulate the Redifferentiation of Chondrocytes |
| title_full |
Strategies to Modulate the Redifferentiation of Chondrocytes |
| title_fullStr |
Strategies to Modulate the Redifferentiation of Chondrocytes |
| title_full_unstemmed |
Strategies to Modulate the Redifferentiation of Chondrocytes |
| title_sort |
strategies to modulate the redifferentiation of chondrocytes |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/73a0ca65e44147a99d126dd5e83eab83 |
| work_keys_str_mv |
AT xiaoshenhu strategiestomodulatetheredifferentiationofchondrocytes AT weiyangzhang strategiestomodulatetheredifferentiationofchondrocytes AT xiangli strategiestomodulatetheredifferentiationofchondrocytes AT donglingzhong strategiestomodulatetheredifferentiationofchondrocytes AT yuxili strategiestomodulatetheredifferentiationofchondrocytes AT juanli strategiestomodulatetheredifferentiationofchondrocytes AT rongjiangjin strategiestomodulatetheredifferentiationofchondrocytes |
| _version_ |
1718418110074060800 |