Hypertension and hyperglycemia synergize to cause incipient renal tubular alterations resulting in increased NGAL urinary excretion in rats.

<h4>Background</h4>Hypertension and diabetes are the two leading causes of chronic kidney disease (CKD) eventually leading to end stage renal disease (ESRD) and the need of renal replacement therapy. Mortality among CKD and ESRD patients is high, mostly due to cardiovascular events. New...

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Autores principales:	Ana M Blázquez-Medela, Omar García-Sánchez, Víctor Blanco-Gozalo, Yaremi Quiros, María J Montero, Carlos Martínez-Salgado, José M López-Novoa, Francisco J López-Hernández
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/73a0e3e27fe94d44a6e650ef33050f6a
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spelling	oai:doaj.org-article:73a0e3e27fe94d44a6e650ef33050f6a2021-11-25T06:03:32ZHypertension and hyperglycemia synergize to cause incipient renal tubular alterations resulting in increased NGAL urinary excretion in rats.1932-620310.1371/journal.pone.0105988https://doaj.org/article/73a0e3e27fe94d44a6e650ef33050f6a2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25148248/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Hypertension and diabetes are the two leading causes of chronic kidney disease (CKD) eventually leading to end stage renal disease (ESRD) and the need of renal replacement therapy. Mortality among CKD and ESRD patients is high, mostly due to cardiovascular events. New early markers of risk are necessary to better anticipate the course of the disease, to detect the renal affection of additive risk factors, and to appropriately handle patients in a pre-emptive and personalized manner.<h4>Methods</h4>Renal function and NGAL urinary excretion was monitored in rats with spontaneous (SHR) or L-NAME induced hypertension rendered hyperglycemic (or not as controls).<h4>Results</h4>Combination of hypertension and hyperglycemia (but not each of these factors independently) causes an increased urinary excretion of neutrophil gelatinase-associated lipocalin (NGAL) in the rat, in the absence of signs of renal damage. Increased NGAL excretion is observed in diabetic animals with two independent models of hypertension. Elevated urinary NGAL results from a specific alteration in its tubular handling, rather than from an increase in its renal expression. In fact, when kidneys of hyperglycaemic-hypertensive rats are perfused in situ with Krebs-dextran solution containing exogenous NGAL, they excrete more NGAL in the urine than hypertensive rats. We also show that albuminuria is not capable of detecting the additive effect posed by the coexistence of these two risk factors.<h4>Conclusions</h4>Our results suggest that accumulation of hypertension and hyperglycemia induces an incipient and quite specific alteration in the tubular handling of NGAL resulting in its increased urinary excretion.Ana M Blázquez-MedelaOmar García-SánchezVíctor Blanco-GozaloYaremi QuirosMaría J MonteroCarlos Martínez-SalgadoJosé M López-NovoaFrancisco J López-HernándezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e105988 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ana M Blázquez-Medela Omar García-Sánchez Víctor Blanco-Gozalo Yaremi Quiros María J Montero Carlos Martínez-Salgado José M López-Novoa Francisco J López-Hernández Hypertension and hyperglycemia synergize to cause incipient renal tubular alterations resulting in increased NGAL urinary excretion in rats.
description	<h4>Background</h4>Hypertension and diabetes are the two leading causes of chronic kidney disease (CKD) eventually leading to end stage renal disease (ESRD) and the need of renal replacement therapy. Mortality among CKD and ESRD patients is high, mostly due to cardiovascular events. New early markers of risk are necessary to better anticipate the course of the disease, to detect the renal affection of additive risk factors, and to appropriately handle patients in a pre-emptive and personalized manner.<h4>Methods</h4>Renal function and NGAL urinary excretion was monitored in rats with spontaneous (SHR) or L-NAME induced hypertension rendered hyperglycemic (or not as controls).<h4>Results</h4>Combination of hypertension and hyperglycemia (but not each of these factors independently) causes an increased urinary excretion of neutrophil gelatinase-associated lipocalin (NGAL) in the rat, in the absence of signs of renal damage. Increased NGAL excretion is observed in diabetic animals with two independent models of hypertension. Elevated urinary NGAL results from a specific alteration in its tubular handling, rather than from an increase in its renal expression. In fact, when kidneys of hyperglycaemic-hypertensive rats are perfused in situ with Krebs-dextran solution containing exogenous NGAL, they excrete more NGAL in the urine than hypertensive rats. We also show that albuminuria is not capable of detecting the additive effect posed by the coexistence of these two risk factors.<h4>Conclusions</h4>Our results suggest that accumulation of hypertension and hyperglycemia induces an incipient and quite specific alteration in the tubular handling of NGAL resulting in its increased urinary excretion.
format	article
author	Ana M Blázquez-Medela Omar García-Sánchez Víctor Blanco-Gozalo Yaremi Quiros María J Montero Carlos Martínez-Salgado José M López-Novoa Francisco J López-Hernández
author_facet	Ana M Blázquez-Medela Omar García-Sánchez Víctor Blanco-Gozalo Yaremi Quiros María J Montero Carlos Martínez-Salgado José M López-Novoa Francisco J López-Hernández
author_sort	Ana M Blázquez-Medela
title	Hypertension and hyperglycemia synergize to cause incipient renal tubular alterations resulting in increased NGAL urinary excretion in rats.
title_short	Hypertension and hyperglycemia synergize to cause incipient renal tubular alterations resulting in increased NGAL urinary excretion in rats.
title_full	Hypertension and hyperglycemia synergize to cause incipient renal tubular alterations resulting in increased NGAL urinary excretion in rats.
title_fullStr	Hypertension and hyperglycemia synergize to cause incipient renal tubular alterations resulting in increased NGAL urinary excretion in rats.
title_full_unstemmed	Hypertension and hyperglycemia synergize to cause incipient renal tubular alterations resulting in increased NGAL urinary excretion in rats.
title_sort	hypertension and hyperglycemia synergize to cause incipient renal tubular alterations resulting in increased ngal urinary excretion in rats.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/73a0e3e27fe94d44a6e650ef33050f6a
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Hypertension and hyperglycemia synergize to cause incipient renal tubular alterations resulting in increased NGAL urinary excretion in rats.

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