Early Hyperdynamic Sepsis Alters Coronary Blood Flow Regulation in Porcine Fecal Peritonitis

Background: Sepsis is a common condition known to impair blood flow regulation and microcirculation, which can ultimately lead to organ dysfunction but such contribution of the coronary circulation remains to be clarified. We investigated coronary blood flow regulatory mechanisms, including autoregu...

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Autores principales:	Céline Boudart, Fuhong Su, Lorenzo Pitisci, Arnaud Dhoine, Olivier Duranteau, Pascale Jespers, Antoine Herpain, Rebecca Vanderpool, Serge Brimioulle, Jacques Creteur, Robert Naeije, Luc Van Obbergh, Laurence Dewachter
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	coronary blood flow autoregulation sepsis metabolic regulation endothelial function microcirculation Physiology QP1-981
Acceso en línea:	https://doaj.org/article/73a1ba16fb83406b885c71c9121e144f
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spelling	oai:doaj.org-article:73a1ba16fb83406b885c71c9121e144f2021-12-03T06:14:21ZEarly Hyperdynamic Sepsis Alters Coronary Blood Flow Regulation in Porcine Fecal Peritonitis1664-042X10.3389/fphys.2021.754570https://doaj.org/article/73a1ba16fb83406b885c71c9121e144f2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.754570/fullhttps://doaj.org/toc/1664-042XBackground: Sepsis is a common condition known to impair blood flow regulation and microcirculation, which can ultimately lead to organ dysfunction but such contribution of the coronary circulation remains to be clarified. We investigated coronary blood flow regulatory mechanisms, including autoregulation, metabolic regulation, and endothelial vasodilatory response, in an experimental porcine model of early hyperdynamic sepsis.Methods: Fourteen pigs were randomized to sham (n = 7) or fecal peritonitis-induced sepsis (n = 7) procedures. At baseline, 6 and 12 h after peritonitis induction, the animals underwent general and coronary hemodynamic evaluation, including determination of autoregulatory breakpoint pressure and adenosine-induced maximal coronary vasodilation for coronary flow reserve and hyperemic microvascular resistance calculation. Endothelial-derived vasodilatory response was assessed both in vivo and ex vivo using bradykinin. Coronary arteries were sampled for pathobiological evaluation.Results: Sepsis resulted in a right shift of the autoregulatory breakpoint pressure, decreased coronary blood flow reserve and increased hyperemic microvascular resistance from the 6th h after peritonitis induction. In vivo and ex vivo endothelial vasomotor function was preserved. Sepsis increased coronary arteries expressions of nitric oxide synthases, prostaglandin I2 receptor, and prostaglandin F2α receptor.Conclusion: Autoregulation and metabolic blood flow regulation were both impaired in the coronary circulation during experimental hyperdynamic sepsis, although endothelial vasodilatory response was preserved.Céline BoudartCéline BoudartFuhong SuLorenzo PitisciArnaud DhoineArnaud DhoineOlivier DuranteauPascale JespersAntoine HerpainRebecca VanderpoolSerge BrimioulleJacques CreteurRobert NaeijeLuc Van ObberghLaurence DewachterFrontiers Media S.A.articlecoronary blood flowautoregulationsepsismetabolic regulationendothelial functionmicrocirculationPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	coronary blood flow autoregulation sepsis metabolic regulation endothelial function microcirculation Physiology QP1-981
spellingShingle	coronary blood flow autoregulation sepsis metabolic regulation endothelial function microcirculation Physiology QP1-981 Céline Boudart Céline Boudart Fuhong Su Lorenzo Pitisci Arnaud Dhoine Arnaud Dhoine Olivier Duranteau Pascale Jespers Antoine Herpain Rebecca Vanderpool Serge Brimioulle Jacques Creteur Robert Naeije Luc Van Obbergh Laurence Dewachter Early Hyperdynamic Sepsis Alters Coronary Blood Flow Regulation in Porcine Fecal Peritonitis
description	Background: Sepsis is a common condition known to impair blood flow regulation and microcirculation, which can ultimately lead to organ dysfunction but such contribution of the coronary circulation remains to be clarified. We investigated coronary blood flow regulatory mechanisms, including autoregulation, metabolic regulation, and endothelial vasodilatory response, in an experimental porcine model of early hyperdynamic sepsis.Methods: Fourteen pigs were randomized to sham (n = 7) or fecal peritonitis-induced sepsis (n = 7) procedures. At baseline, 6 and 12 h after peritonitis induction, the animals underwent general and coronary hemodynamic evaluation, including determination of autoregulatory breakpoint pressure and adenosine-induced maximal coronary vasodilation for coronary flow reserve and hyperemic microvascular resistance calculation. Endothelial-derived vasodilatory response was assessed both in vivo and ex vivo using bradykinin. Coronary arteries were sampled for pathobiological evaluation.Results: Sepsis resulted in a right shift of the autoregulatory breakpoint pressure, decreased coronary blood flow reserve and increased hyperemic microvascular resistance from the 6th h after peritonitis induction. In vivo and ex vivo endothelial vasomotor function was preserved. Sepsis increased coronary arteries expressions of nitric oxide synthases, prostaglandin I2 receptor, and prostaglandin F2α receptor.Conclusion: Autoregulation and metabolic blood flow regulation were both impaired in the coronary circulation during experimental hyperdynamic sepsis, although endothelial vasodilatory response was preserved.
format	article
author	Céline Boudart Céline Boudart Fuhong Su Lorenzo Pitisci Arnaud Dhoine Arnaud Dhoine Olivier Duranteau Pascale Jespers Antoine Herpain Rebecca Vanderpool Serge Brimioulle Jacques Creteur Robert Naeije Luc Van Obbergh Laurence Dewachter
author_facet	Céline Boudart Céline Boudart Fuhong Su Lorenzo Pitisci Arnaud Dhoine Arnaud Dhoine Olivier Duranteau Pascale Jespers Antoine Herpain Rebecca Vanderpool Serge Brimioulle Jacques Creteur Robert Naeije Luc Van Obbergh Laurence Dewachter
author_sort	Céline Boudart
title	Early Hyperdynamic Sepsis Alters Coronary Blood Flow Regulation in Porcine Fecal Peritonitis
title_short	Early Hyperdynamic Sepsis Alters Coronary Blood Flow Regulation in Porcine Fecal Peritonitis
title_full	Early Hyperdynamic Sepsis Alters Coronary Blood Flow Regulation in Porcine Fecal Peritonitis
title_fullStr	Early Hyperdynamic Sepsis Alters Coronary Blood Flow Regulation in Porcine Fecal Peritonitis
title_full_unstemmed	Early Hyperdynamic Sepsis Alters Coronary Blood Flow Regulation in Porcine Fecal Peritonitis
title_sort	early hyperdynamic sepsis alters coronary blood flow regulation in porcine fecal peritonitis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/73a1ba16fb83406b885c71c9121e144f
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Early Hyperdynamic Sepsis Alters Coronary Blood Flow Regulation in Porcine Fecal Peritonitis

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