Age, Gender, and Seasonal Effects on Thyroid Profile in Adults with Normal Thyroid Functions

Background: Thyroid hormone variations have been observed according to age and sex. Seasonal effects also induce variations in thyroid function even in people with normal thyroid levels. The majority of clinical laboratories follow a single reference range without the consideration of age, gender,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sajjad Ahmad, Haji Muhammad Rashid, Hiza Hassan, Muhammad Mujahid, Maryam Gul
Formato:	article
Lenguaje:	EN
Publicado:	Jinnah University for Women 2021
Materias:	Age, FT3, FT4, Gender, Seasons, TSH. Medicine R Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/73a95ba3a7f440678424de8dbe05254d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:73a95ba3a7f440678424de8dbe05254d
record_format	dspace
spelling	oai:doaj.org-article:73a95ba3a7f440678424de8dbe05254d2021-11-25T06:47:13ZAge, Gender, and Seasonal Effects on Thyroid Profile in Adults with Normal Thyroid Functions10.37962/jbas.v12i1.4052305-87222521-8573https://doaj.org/article/73a95ba3a7f440678424de8dbe05254d2021-07-01T00:00:00Zhttp://jbas.juw.edu.pk/index.php/JBAS/article/view/405https://doaj.org/toc/2305-8722https://doaj.org/toc/2521-8573 Background: Thyroid hormone variations have been observed according to age and sex. Seasonal effects also induce variations in thyroid function even in people with normal thyroid levels. The majority of clinical laboratories follow a single reference range without the consideration of age, gender, and especially seasonal variations in thyroid function tests. Objectives: To evaluate age, gender, and seasonal variations in thyroid function tests in adults with normal thyroid functions. Methodology: This cross sectional study was carried out at Pathology Department, Quaid-e-Azam Medical College, Bahawalpur. One year data from Jan 2018 to Jan 2019 of thyroid function tests (TSH, T3 and T4) and demographic details were obtained for all those patients whose Thyroid Stimulating Hormone (TSH) was in normal reference range (0.5-4.5mU/L). We found the data of 418 subjects from 16 to 75 years of age, among them 196 were females and 222 were males. Results: Serum TSH levels were higher in females (2.11mU/L ±1.54) than serum TSH levels of males (1.59mU/L ±1.2) with a p-value of 0.0002. FT4 levels (normal range: 0.89-1.76ng/dL) were significantly lower (p-value 0.0018) in females (1.33ng/dL ±0.50) as compared to males (1.48ng/dL ±0.48). In <20 years of the age group of both genders, serum TSH was at lowest levels, while highest in 20-40 years of the age group of males and >60 years of females. The mean TSH of all subjects was high (2.98mU/L) in winters and it was low (2.4mU/L) in autumn. FT4 was at the lowest level (1.16ng/dL) in winters and it was highest (1.46ng/dL) in summers. FT3 levels in the winter season were higher than in other seasons. Conclusion: Age, gender, and season affects the thyroid hormones levels, and these factors should be considered while interpreting the lab results of thyroid function tests. Sajjad AhmadHaji Muhammad RashidHiza HassanMuhammad MujahidMaryam GulJinnah University for WomenarticleAge, FT3, FT4, Gender, Seasons, TSH.MedicineRBiology (General)QH301-705.5ENRADS Journal of Biological Research & Applied Science, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Age, FT3, FT4, Gender, Seasons, TSH. Medicine R Biology (General) QH301-705.5
spellingShingle	Age, FT3, FT4, Gender, Seasons, TSH. Medicine R Biology (General) QH301-705.5 Sajjad Ahmad Haji Muhammad Rashid Hiza Hassan Muhammad Mujahid Maryam Gul Age, Gender, and Seasonal Effects on Thyroid Profile in Adults with Normal Thyroid Functions
description	Background: Thyroid hormone variations have been observed according to age and sex. Seasonal effects also induce variations in thyroid function even in people with normal thyroid levels. The majority of clinical laboratories follow a single reference range without the consideration of age, gender, and especially seasonal variations in thyroid function tests. Objectives: To evaluate age, gender, and seasonal variations in thyroid function tests in adults with normal thyroid functions. Methodology: This cross sectional study was carried out at Pathology Department, Quaid-e-Azam Medical College, Bahawalpur. One year data from Jan 2018 to Jan 2019 of thyroid function tests (TSH, T3 and T4) and demographic details were obtained for all those patients whose Thyroid Stimulating Hormone (TSH) was in normal reference range (0.5-4.5mU/L). We found the data of 418 subjects from 16 to 75 years of age, among them 196 were females and 222 were males. Results: Serum TSH levels were higher in females (2.11mU/L ±1.54) than serum TSH levels of males (1.59mU/L ±1.2) with a p-value of 0.0002. FT4 levels (normal range: 0.89-1.76ng/dL) were significantly lower (p-value 0.0018) in females (1.33ng/dL ±0.50) as compared to males (1.48ng/dL ±0.48). In <20 years of the age group of both genders, serum TSH was at lowest levels, while highest in 20-40 years of the age group of males and >60 years of females. The mean TSH of all subjects was high (2.98mU/L) in winters and it was low (2.4mU/L) in autumn. FT4 was at the lowest level (1.16ng/dL) in winters and it was highest (1.46ng/dL) in summers. FT3 levels in the winter season were higher than in other seasons. Conclusion: Age, gender, and season affects the thyroid hormones levels, and these factors should be considered while interpreting the lab results of thyroid function tests.
format	article
author	Sajjad Ahmad Haji Muhammad Rashid Hiza Hassan Muhammad Mujahid Maryam Gul
author_facet	Sajjad Ahmad Haji Muhammad Rashid Hiza Hassan Muhammad Mujahid Maryam Gul
author_sort	Sajjad Ahmad
title	Age, Gender, and Seasonal Effects on Thyroid Profile in Adults with Normal Thyroid Functions
title_short	Age, Gender, and Seasonal Effects on Thyroid Profile in Adults with Normal Thyroid Functions
title_full	Age, Gender, and Seasonal Effects on Thyroid Profile in Adults with Normal Thyroid Functions
title_fullStr	Age, Gender, and Seasonal Effects on Thyroid Profile in Adults with Normal Thyroid Functions
title_full_unstemmed	Age, Gender, and Seasonal Effects on Thyroid Profile in Adults with Normal Thyroid Functions
title_sort	age, gender, and seasonal effects on thyroid profile in adults with normal thyroid functions
publisher	Jinnah University for Women
publishDate	2021
url	https://doaj.org/article/73a95ba3a7f440678424de8dbe05254d
work_keys_str_mv	AT sajjadahmad agegenderandseasonaleffectsonthyroidprofileinadultswithnormalthyroidfunctions AT hajimuhammadrashid agegenderandseasonaleffectsonthyroidprofileinadultswithnormalthyroidfunctions AT hizahassan agegenderandseasonaleffectsonthyroidprofileinadultswithnormalthyroidfunctions AT muhammadmujahid agegenderandseasonaleffectsonthyroidprofileinadultswithnormalthyroidfunctions AT maryamgul agegenderandseasonaleffectsonthyroidprofileinadultswithnormalthyroidfunctions
_version_	1718413626078920704

Age, Gender, and Seasonal Effects on Thyroid Profile in Adults with Normal Thyroid Functions

Ejemplares similares