Dynamics of the Level of Myeloperoxidase and Serum Calprotectin in Local Cold Injury

Relevance. Cold injury is defined as a complex of pathophysiological and pathomorphological changes arising as a result of local or general cooling of the human body. Endothelial dysfunction provokes a powerful cascade of cellular interactions with expressed excretory activity, which ultimately lead...

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Autores principales:	M. I. Mikhailichenko, K. G. Shapovalov, V. A. Mudrov, O. S. Gruzdeva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2020
Materias:	local cold injury endothelial dysfunction myeloperoxidase serum calprotectin microcirculation Science Q
Acceso en línea:	https://doaj.org/article/73aa2ead81c043ca9c1060e2b5d81633
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spelling	oai:doaj.org-article:73aa2ead81c043ca9c1060e2b5d816332021-11-23T06:14:44ZDynamics of the Level of Myeloperoxidase and Serum Calprotectin in Local Cold Injury2541-94202587-959610.29413/ABS.2020-5.3.3https://doaj.org/article/73aa2ead81c043ca9c1060e2b5d816332020-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2363https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Relevance. Cold injury is defined as a complex of pathophysiological and pathomorphological changes arising as a result of local or general cooling of the human body. Endothelial dysfunction provokes a powerful cascade of cellular interactions with expressed excretory activity, which ultimately leads to a pronounced remodeling of microcirculation and a protracted process of inflammation in the focus of alterations. Aim of the study. To establish the dynamics of the level of myeloperoxidase and calprotectin in the serum of patients with local cold injury. Materials and methods. The study included 80 patients with III–IV degree lesions in the late reactive period and the period of granulation and epithelialization. The average age of patients was 38 ± 8 years. The myeloperoxidase level was measured on the 5th and 30th days from the moment of cryopreservation using multiplex analysis of blood serum. Results. The level of myeloperoxidase and serum calprotectin increases. In late reactive period (day 5), MPO level in patients with frostbite is 7.25 times higher in comparison with control values, in the period of granulation and epithelialization (day 30), it remains elevated, but only 3.63 times higher than in the control group. In the late reactive period, the level of calprotectin in the blood serum of patients with local cold injury was 4.6 times higher in comparison with control values, and on the 30th day of cryopreservation, the value of calprotectin was 4.5 times higher than in the control group. Changes in the level of myeloperoxidase and serum calprotectin reflect the flow of destructive and reparative mechanisms in tissues during local cold trauma and can be used in predicting an unfavorable prolonged course of the wound process.M. I. MikhailichenkoK. G. ShapovalovV. A. MudrovO. S. GruzdevaScientific Сentre for Family Health and Human Reproduction Problemsarticlelocal cold injuryendothelial dysfunctionmyeloperoxidaseserum calprotectinmicrocirculationScienceQRUActa Biomedica Scientifica, Vol 5, Iss 3, Pp 24-28 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	local cold injury endothelial dysfunction myeloperoxidase serum calprotectin microcirculation Science Q
spellingShingle	local cold injury endothelial dysfunction myeloperoxidase serum calprotectin microcirculation Science Q M. I. Mikhailichenko K. G. Shapovalov V. A. Mudrov O. S. Gruzdeva Dynamics of the Level of Myeloperoxidase and Serum Calprotectin in Local Cold Injury
description	Relevance. Cold injury is defined as a complex of pathophysiological and pathomorphological changes arising as a result of local or general cooling of the human body. Endothelial dysfunction provokes a powerful cascade of cellular interactions with expressed excretory activity, which ultimately leads to a pronounced remodeling of microcirculation and a protracted process of inflammation in the focus of alterations. Aim of the study. To establish the dynamics of the level of myeloperoxidase and calprotectin in the serum of patients with local cold injury. Materials and methods. The study included 80 patients with III–IV degree lesions in the late reactive period and the period of granulation and epithelialization. The average age of patients was 38 ± 8 years. The myeloperoxidase level was measured on the 5th and 30th days from the moment of cryopreservation using multiplex analysis of blood serum. Results. The level of myeloperoxidase and serum calprotectin increases. In late reactive period (day 5), MPO level in patients with frostbite is 7.25 times higher in comparison with control values, in the period of granulation and epithelialization (day 30), it remains elevated, but only 3.63 times higher than in the control group. In the late reactive period, the level of calprotectin in the blood serum of patients with local cold injury was 4.6 times higher in comparison with control values, and on the 30th day of cryopreservation, the value of calprotectin was 4.5 times higher than in the control group. Changes in the level of myeloperoxidase and serum calprotectin reflect the flow of destructive and reparative mechanisms in tissues during local cold trauma and can be used in predicting an unfavorable prolonged course of the wound process.
format	article
author	M. I. Mikhailichenko K. G. Shapovalov V. A. Mudrov O. S. Gruzdeva
author_facet	M. I. Mikhailichenko K. G. Shapovalov V. A. Mudrov O. S. Gruzdeva
author_sort	M. I. Mikhailichenko
title	Dynamics of the Level of Myeloperoxidase and Serum Calprotectin in Local Cold Injury
title_short	Dynamics of the Level of Myeloperoxidase and Serum Calprotectin in Local Cold Injury
title_full	Dynamics of the Level of Myeloperoxidase and Serum Calprotectin in Local Cold Injury
title_fullStr	Dynamics of the Level of Myeloperoxidase and Serum Calprotectin in Local Cold Injury
title_full_unstemmed	Dynamics of the Level of Myeloperoxidase and Serum Calprotectin in Local Cold Injury
title_sort	dynamics of the level of myeloperoxidase and serum calprotectin in local cold injury
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2020
url	https://doaj.org/article/73aa2ead81c043ca9c1060e2b5d81633
work_keys_str_mv	AT mimikhailichenko dynamicsofthelevelofmyeloperoxidaseandserumcalprotectininlocalcoldinjury AT kgshapovalov dynamicsofthelevelofmyeloperoxidaseandserumcalprotectininlocalcoldinjury AT vamudrov dynamicsofthelevelofmyeloperoxidaseandserumcalprotectininlocalcoldinjury AT osgruzdeva dynamicsofthelevelofmyeloperoxidaseandserumcalprotectininlocalcoldinjury
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Dynamics of the Level of Myeloperoxidase and Serum Calprotectin in Local Cold Injury

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