Putative associations between inflammatory biomarkers, obesity, and obstructive sleep apnea

BACKGROUND: Previous studies have reported increased levels of inflammatory mediators in patients with obstructive sleep apnea (OSA), but their relation with the severity of OSA is controversial.OBJECTIVE: To address potential relationships between OSA-related inflammatory markers, namely, C-reactiv...

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Autores principales:	Siraj Omar Wali, Md Dilshad Manzar, Mohammed M Abdelaziz, Ranya Alshomrani, Faris Alhejaili, Jamil Al-Mughales, Wail Alamoudi, David Gozal
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	c-reactive protein fibrinogen inflammation interleukin-6 obstructive sleep apnea spo2 tumor necrosis factor-alpha Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/73ac318df1664c3181fc0ff1512553c1
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spelling	oai:doaj.org-article:73ac318df1664c3181fc0ff1512553c12021-11-12T10:08:17ZPutative associations between inflammatory biomarkers, obesity, and obstructive sleep apnea1817-17371998-355710.4103/atm.atm_644_20https://doaj.org/article/73ac318df1664c3181fc0ff1512553c12021-01-01T00:00:00Zhttp://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2021;volume=16;issue=4;spage=329;epage=336;aulast=Walihttps://doaj.org/toc/1817-1737https://doaj.org/toc/1998-3557BACKGROUND: Previous studies have reported increased levels of inflammatory mediators in patients with obstructive sleep apnea (OSA), but their relation with the severity of OSA is controversial.OBJECTIVE: To address potential relationships between OSA-related inflammatory markers, namely, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and fibrinogen, with different oxygenation parameters and with BMI.METHODS: All eligible patients with suspected OSA newly referred to the Sleep Medicine Research Center at King Abdulaziz University Hospital, Jeddah, were evaluated demographically and anthropometrically, and underwent overnight polysomnography. Fasting morning blood samples were collected to measure serum levels of CRP, fibrinogen, TNF-α, and IL-6. Potential correlations between these inflammatory mediators and severity measures of OSA and body mass index (BMI) were explored.RESULTS: Sixty-four patients completed the study (40 with OSA and 24 without OSA). Significantly increased levels of CRP, fibrinogen, IL-6, and TNF-α emerged in patients with OSA compared to non-OSA. Significant associations between log CRP and log fibrinogen levels emerged with increasing BMI. However, there was no significant association between any of the inflammatory markers and the severity of OSA based on the apnea/hypopnea index or oxyhemoglobin saturation-derived parameters.CONCLUSIONS: OSA patients exhibit increased levels of inflammatory mediators that do not appear to be associated with polysomnographic measures, but exhibit positive correlation with the degree of adiposity.Siraj Omar WaliMd Dilshad ManzarMohammed M AbdelazizRanya AlshomraniFaris AlhejailiJamil Al-MughalesWail AlamoudiDavid GozalWolters Kluwer Medknow Publicationsarticlec-reactive proteinfibrinogeninflammationinterleukin-6obstructive sleep apneaspo2tumor necrosis factor-alphaDiseases of the circulatory (Cardiovascular) systemRC666-701Diseases of the respiratory systemRC705-779ENAnnals of Thoracic Medicine, Vol 16, Iss 4, Pp 329-336 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	c-reactive protein fibrinogen inflammation interleukin-6 obstructive sleep apnea spo2 tumor necrosis factor-alpha Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the respiratory system RC705-779
spellingShingle	c-reactive protein fibrinogen inflammation interleukin-6 obstructive sleep apnea spo2 tumor necrosis factor-alpha Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the respiratory system RC705-779 Siraj Omar Wali Md Dilshad Manzar Mohammed M Abdelaziz Ranya Alshomrani Faris Alhejaili Jamil Al-Mughales Wail Alamoudi David Gozal Putative associations between inflammatory biomarkers, obesity, and obstructive sleep apnea
description	BACKGROUND: Previous studies have reported increased levels of inflammatory mediators in patients with obstructive sleep apnea (OSA), but their relation with the severity of OSA is controversial.OBJECTIVE: To address potential relationships between OSA-related inflammatory markers, namely, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and fibrinogen, with different oxygenation parameters and with BMI.METHODS: All eligible patients with suspected OSA newly referred to the Sleep Medicine Research Center at King Abdulaziz University Hospital, Jeddah, were evaluated demographically and anthropometrically, and underwent overnight polysomnography. Fasting morning blood samples were collected to measure serum levels of CRP, fibrinogen, TNF-α, and IL-6. Potential correlations between these inflammatory mediators and severity measures of OSA and body mass index (BMI) were explored.RESULTS: Sixty-four patients completed the study (40 with OSA and 24 without OSA). Significantly increased levels of CRP, fibrinogen, IL-6, and TNF-α emerged in patients with OSA compared to non-OSA. Significant associations between log CRP and log fibrinogen levels emerged with increasing BMI. However, there was no significant association between any of the inflammatory markers and the severity of OSA based on the apnea/hypopnea index or oxyhemoglobin saturation-derived parameters.CONCLUSIONS: OSA patients exhibit increased levels of inflammatory mediators that do not appear to be associated with polysomnographic measures, but exhibit positive correlation with the degree of adiposity.
format	article
author	Siraj Omar Wali Md Dilshad Manzar Mohammed M Abdelaziz Ranya Alshomrani Faris Alhejaili Jamil Al-Mughales Wail Alamoudi David Gozal
author_facet	Siraj Omar Wali Md Dilshad Manzar Mohammed M Abdelaziz Ranya Alshomrani Faris Alhejaili Jamil Al-Mughales Wail Alamoudi David Gozal
author_sort	Siraj Omar Wali
title	Putative associations between inflammatory biomarkers, obesity, and obstructive sleep apnea
title_short	Putative associations between inflammatory biomarkers, obesity, and obstructive sleep apnea
title_full	Putative associations between inflammatory biomarkers, obesity, and obstructive sleep apnea
title_fullStr	Putative associations between inflammatory biomarkers, obesity, and obstructive sleep apnea
title_full_unstemmed	Putative associations between inflammatory biomarkers, obesity, and obstructive sleep apnea
title_sort	putative associations between inflammatory biomarkers, obesity, and obstructive sleep apnea
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/73ac318df1664c3181fc0ff1512553c1
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Putative associations between inflammatory biomarkers, obesity, and obstructive sleep apnea

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