The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells

How lipid metabolism can affect cancer recurrence is still unclear. Here, the authors show that the lysophospholipase D Gdpd3 maintains self-renewal capacity of CML stem cells by regulating the quiescence, and AKT/mTORC1 and Foxo3a/β-catenin signalling in an oncogene-independent manner.

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Autores principales:	Kazuhito Naka, Ryosuke Ochiai, Eriko Matsubara, Chie Kondo, Kyung-Min Yang, Takayuki Hoshii, Masatake Araki, Kimi Araki, Yusuke Sotomaru, Ko Sasaki, Kinuko Mitani, Dong-Wook Kim, Akira Ooshima, Seong-Jin Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/73aca2b556d542e499ca1a950b353d8d
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spelling	oai:doaj.org-article:73aca2b556d542e499ca1a950b353d8d2021-12-02T18:02:24ZThe lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells10.1038/s41467-020-18491-92041-1723https://doaj.org/article/73aca2b556d542e499ca1a950b353d8d2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18491-9https://doaj.org/toc/2041-1723How lipid metabolism can affect cancer recurrence is still unclear. Here, the authors show that the lysophospholipase D Gdpd3 maintains self-renewal capacity of CML stem cells by regulating the quiescence, and AKT/mTORC1 and Foxo3a/β-catenin signalling in an oncogene-independent manner.Kazuhito NakaRyosuke OchiaiEriko MatsubaraChie KondoKyung-Min YangTakayuki HoshiiMasatake ArakiKimi ArakiYusuke SotomaruKo SasakiKinuko MitaniDong-Wook KimAkira OoshimaSeong-Jin KimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kazuhito Naka Ryosuke Ochiai Eriko Matsubara Chie Kondo Kyung-Min Yang Takayuki Hoshii Masatake Araki Kimi Araki Yusuke Sotomaru Ko Sasaki Kinuko Mitani Dong-Wook Kim Akira Ooshima Seong-Jin Kim The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells
description	How lipid metabolism can affect cancer recurrence is still unclear. Here, the authors show that the lysophospholipase D Gdpd3 maintains self-renewal capacity of CML stem cells by regulating the quiescence, and AKT/mTORC1 and Foxo3a/β-catenin signalling in an oncogene-independent manner.
format	article
author	Kazuhito Naka Ryosuke Ochiai Eriko Matsubara Chie Kondo Kyung-Min Yang Takayuki Hoshii Masatake Araki Kimi Araki Yusuke Sotomaru Ko Sasaki Kinuko Mitani Dong-Wook Kim Akira Ooshima Seong-Jin Kim
author_facet	Kazuhito Naka Ryosuke Ochiai Eriko Matsubara Chie Kondo Kyung-Min Yang Takayuki Hoshii Masatake Araki Kimi Araki Yusuke Sotomaru Ko Sasaki Kinuko Mitani Dong-Wook Kim Akira Ooshima Seong-Jin Kim
author_sort	Kazuhito Naka
title	The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells
title_short	The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells
title_full	The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells
title_fullStr	The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells
title_full_unstemmed	The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells
title_sort	lysophospholipase d enzyme gdpd3 is required to maintain chronic myelogenous leukaemia stem cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/73aca2b556d542e499ca1a950b353d8d
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The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells

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