A comparative in vivo study of strontium-functionalized and SLActive™ implant surfaces in early bone healing

Vincent Offermanns,1 Ole Z Andersen,2 Michael Sillassen,2 Klaus P Almtoft,3 Inge H Andersen,3 Frank Kloss,4 Morten Foss2,5 1Department of Cranio-Maxillofacial and Oral Surgery, Medical University of Innsbruck, Innsbruck, Austria; 2Interdisciplinary Nanoscience Center (iNANO), Faculty of Science and...

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Autores principales: Offermanns V, Andersen OZ, Sillassen M, Almtoft KP, Andersen IH, Kloss F, Foss M
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Publicado: Dove Medical Press 2018
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spelling oai:doaj.org-article:73aedf3d305b42908d4614ee8f2ef48d2021-12-02T06:15:43ZA comparative in vivo study of strontium-functionalized and SLActive™ implant surfaces in early bone healing1178-2013https://doaj.org/article/73aedf3d305b42908d4614ee8f2ef48d2018-04-01T00:00:00Zhttps://www.dovepress.com/a-comparative-in-vivo-study-of-strontium-functionalized-and-slactivetm-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Vincent Offermanns,1 Ole Z Andersen,2 Michael Sillassen,2 Klaus P Almtoft,3 Inge H Andersen,3 Frank Kloss,4 Morten Foss2,5 1Department of Cranio-Maxillofacial and Oral Surgery, Medical University of Innsbruck, Innsbruck, Austria; 2Interdisciplinary Nanoscience Center (iNANO), Faculty of Science and Technology, Aarhus University, Aarhus, Denmark; 3Tribology Center, Danish Technological Institute, Aarhus, Denmark; 4Private Practice, Lienz, Austria; 5Department of Physics and Astronomy, Faculty of Science and Technology, Aarhus University, Aarhus, Denmark Purpose: Studies have shown that strontium-doped medical applications benefit bone metabolism leading to improved bone healing and osseointegration. Based on this knowledge, the aim of the study was to evaluate the performance of an implant surface, functionalized by a physical vapor deposition (PVD) coating (Ti-Sr-O), designed to yield predictable release of strontium. The Ti-Sr-O functionalized surface is compared to a routinely used, commercially available surface (SLActive™) with respect to bone-to-implant contact (BIC%) and new bone formation (BF%) in two defined regions of interest (ROI-I and ROI-II, respectively).Materials and methods: Ti-Sr-O functionalized, SLActive, and Grade 4 titanium implants were inserted in the femoral condyle of adult male New Zealand White rabbits. The PVD magnetron-sputtered Ti-Sr-O surface coating was characterized using scanning electron microscopy (SEM) for morphology and coating thickness. Strontium release and mechanical stability of the coating, under simulated insertion conditions, were evaluated. Furthermore, histomorphometrical BIC and BF were carried out 2 weeks after insertion.Results: Histomorphometry revealed increased bone formation of Ti-Sr-O with significant differences compared to SLActive and Grade 4 titanium in both regions of interest, ROI-I and ROI-II, at 0–250 µm and 250–500 µm distance from the implant surfaces. Analogous results of bone-to-implant contact were observed for the two modified surfaces. Conclusion: The results show that a nanopatterned Ti-Sr-O functionalized titanium surface, with sustained release of strontium, increases peri-implant bone volume and could potentially contribute to enhancement of bone anchorage of osseointegrated implants. Keywords: biofunctionalization, wettability, physical vapor deposition, bioactive, surface modification, bone Offermanns VAndersen OZSillassen MAlmtoft KPAndersen IHKloss FFoss MDove Medical Pressarticlebiofunctionalizationwettabilityphysical vapor depositionbioactivesurface modificationboneMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 2189-2197 (2018)
institution DOAJ
collection DOAJ
language EN
topic biofunctionalization
wettability
physical vapor deposition
bioactive
surface modification
bone
Medicine (General)
R5-920
spellingShingle biofunctionalization
wettability
physical vapor deposition
bioactive
surface modification
bone
Medicine (General)
R5-920
Offermanns V
Andersen OZ
Sillassen M
Almtoft KP
Andersen IH
Kloss F
Foss M
A comparative in vivo study of strontium-functionalized and SLActive™ implant surfaces in early bone healing
description Vincent Offermanns,1 Ole Z Andersen,2 Michael Sillassen,2 Klaus P Almtoft,3 Inge H Andersen,3 Frank Kloss,4 Morten Foss2,5 1Department of Cranio-Maxillofacial and Oral Surgery, Medical University of Innsbruck, Innsbruck, Austria; 2Interdisciplinary Nanoscience Center (iNANO), Faculty of Science and Technology, Aarhus University, Aarhus, Denmark; 3Tribology Center, Danish Technological Institute, Aarhus, Denmark; 4Private Practice, Lienz, Austria; 5Department of Physics and Astronomy, Faculty of Science and Technology, Aarhus University, Aarhus, Denmark Purpose: Studies have shown that strontium-doped medical applications benefit bone metabolism leading to improved bone healing and osseointegration. Based on this knowledge, the aim of the study was to evaluate the performance of an implant surface, functionalized by a physical vapor deposition (PVD) coating (Ti-Sr-O), designed to yield predictable release of strontium. The Ti-Sr-O functionalized surface is compared to a routinely used, commercially available surface (SLActive™) with respect to bone-to-implant contact (BIC%) and new bone formation (BF%) in two defined regions of interest (ROI-I and ROI-II, respectively).Materials and methods: Ti-Sr-O functionalized, SLActive, and Grade 4 titanium implants were inserted in the femoral condyle of adult male New Zealand White rabbits. The PVD magnetron-sputtered Ti-Sr-O surface coating was characterized using scanning electron microscopy (SEM) for morphology and coating thickness. Strontium release and mechanical stability of the coating, under simulated insertion conditions, were evaluated. Furthermore, histomorphometrical BIC and BF were carried out 2 weeks after insertion.Results: Histomorphometry revealed increased bone formation of Ti-Sr-O with significant differences compared to SLActive and Grade 4 titanium in both regions of interest, ROI-I and ROI-II, at 0–250 µm and 250–500 µm distance from the implant surfaces. Analogous results of bone-to-implant contact were observed for the two modified surfaces. Conclusion: The results show that a nanopatterned Ti-Sr-O functionalized titanium surface, with sustained release of strontium, increases peri-implant bone volume and could potentially contribute to enhancement of bone anchorage of osseointegrated implants. Keywords: biofunctionalization, wettability, physical vapor deposition, bioactive, surface modification, bone 
format article
author Offermanns V
Andersen OZ
Sillassen M
Almtoft KP
Andersen IH
Kloss F
Foss M
author_facet Offermanns V
Andersen OZ
Sillassen M
Almtoft KP
Andersen IH
Kloss F
Foss M
author_sort Offermanns V
title A comparative in vivo study of strontium-functionalized and SLActive™ implant surfaces in early bone healing
title_short A comparative in vivo study of strontium-functionalized and SLActive™ implant surfaces in early bone healing
title_full A comparative in vivo study of strontium-functionalized and SLActive™ implant surfaces in early bone healing
title_fullStr A comparative in vivo study of strontium-functionalized and SLActive™ implant surfaces in early bone healing
title_full_unstemmed A comparative in vivo study of strontium-functionalized and SLActive™ implant surfaces in early bone healing
title_sort comparative in vivo study of strontium-functionalized and slactive™ implant surfaces in early bone healing
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/73aedf3d305b42908d4614ee8f2ef48d
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