High fidelity blood flow in a patient-specific arteriovenous fistula

Abstract An arteriovenous fistula, created by artificially connecting segments of a patient’s vasculature, is the preferred way to gain access to the bloodstream for kidney dialysis. The increasing power and availability of supercomputing infrastructure means that it is becoming more realistic to us...

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Autores principales:	J. W. S. McCullough, P. V. Coveney
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/73af98419d6846039de28a8f7d17c651
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spelling	oai:doaj.org-article:73af98419d6846039de28a8f7d17c6512021-11-21T12:23:16ZHigh fidelity blood flow in a patient-specific arteriovenous fistula10.1038/s41598-021-01435-82045-2322https://doaj.org/article/73af98419d6846039de28a8f7d17c6512021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01435-8https://doaj.org/toc/2045-2322Abstract An arteriovenous fistula, created by artificially connecting segments of a patient’s vasculature, is the preferred way to gain access to the bloodstream for kidney dialysis. The increasing power and availability of supercomputing infrastructure means that it is becoming more realistic to use simulations to help identify the best type and location of a fistula for a specific patient. We describe a 3D fistula model that uses the lattice Boltzmann method to simultaneously resolve blood flow in patient-specific arteries and veins. The simulations conducted here, comprising vasculatures of the whole forearm, demonstrate qualified validation against clinical data. Ongoing research to further encompass complex biophysics on realistic time scales will permit the use of human-scale physiological models for basic and clinical medicine.J. W. S. McCulloughP. V. CoveneyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q J. W. S. McCullough P. V. Coveney High fidelity blood flow in a patient-specific arteriovenous fistula
description	Abstract An arteriovenous fistula, created by artificially connecting segments of a patient’s vasculature, is the preferred way to gain access to the bloodstream for kidney dialysis. The increasing power and availability of supercomputing infrastructure means that it is becoming more realistic to use simulations to help identify the best type and location of a fistula for a specific patient. We describe a 3D fistula model that uses the lattice Boltzmann method to simultaneously resolve blood flow in patient-specific arteries and veins. The simulations conducted here, comprising vasculatures of the whole forearm, demonstrate qualified validation against clinical data. Ongoing research to further encompass complex biophysics on realistic time scales will permit the use of human-scale physiological models for basic and clinical medicine.
format	article
author	J. W. S. McCullough P. V. Coveney
author_facet	J. W. S. McCullough P. V. Coveney
author_sort	J. W. S. McCullough
title	High fidelity blood flow in a patient-specific arteriovenous fistula
title_short	High fidelity blood flow in a patient-specific arteriovenous fistula
title_full	High fidelity blood flow in a patient-specific arteriovenous fistula
title_fullStr	High fidelity blood flow in a patient-specific arteriovenous fistula
title_full_unstemmed	High fidelity blood flow in a patient-specific arteriovenous fistula
title_sort	high fidelity blood flow in a patient-specific arteriovenous fistula
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/73af98419d6846039de28a8f7d17c651
work_keys_str_mv	AT jwsmccullough highfidelitybloodflowinapatientspecificarteriovenousfistula AT pvcoveney highfidelitybloodflowinapatientspecificarteriovenousfistula
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High fidelity blood flow in a patient-specific arteriovenous fistula

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