Associations between ADIPOQ rs2241766 SNP and breast cancer risk: a systematic review and a meta-analysis

Abstract Purpose We aimed to conduct a meta-analysis to accurately evaluate the potential association between ADIPOQ rs2241766 gene SNP and breast cancer risk. Methods A systematic literature search on Cochrane Library, PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI...

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Autores principales:	Xue Hu, Chunguo Cui, Tong Sun, Wan Wang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Breast Cancer Genetics Meta-analysis Polymorphism Ecology QH540-549.5 QH426-470
Acceso en línea:	https://doaj.org/article/73b182d1f69a466f8deb07f8ea1c1afa
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spelling	oai:doaj.org-article:73b182d1f69a466f8deb07f8ea1c1afa2021-11-08T10:45:26ZAssociations between ADIPOQ rs2241766 SNP and breast cancer risk: a systematic review and a meta-analysis10.1186/s41021-021-00221-21880-7062https://doaj.org/article/73b182d1f69a466f8deb07f8ea1c1afa2021-11-01T00:00:00Zhttps://doi.org/10.1186/s41021-021-00221-2https://doaj.org/toc/1880-7062Abstract Purpose We aimed to conduct a meta-analysis to accurately evaluate the potential association between ADIPOQ rs2241766 gene SNP and breast cancer risk. Methods A systematic literature search on Cochrane Library, PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI) identified 8 articles with 1692 cases and 1890 controls. Strength of association was evaluated by pooled odds ratio (OR), 95 % confidence interval (CI) and p value. Funnel plots and Begger’s regression test were applied for testing the publication bias. Statistical analysis of all data was performed by Stata 12.0. Results The meta-analysis results indicated that the ADIPOQ rs2241766 gene polymorphism did not significantly associated with the risk of breast cancer for these genetic models (TT vs. TG + GG: OR = 1.20, 95 % CI = 0.77–1.89, p=0.417; TT + TG vs. GG: OR = 1.05, 95 % CI = 0.71–1.56, p=0.805; T vs. G: OR =1.17, 95 % CI = 0.79–1.74, p=0.437). Conclusions This study indicated that no significant relationship between the ADIPOQ rs2241766 SNP and breast cancer. Further large-scale and well-designed studies will be indispensable to confirm our result.Xue HuChunguo CuiTong SunWan WangBMCarticleBreastCancerGeneticsMeta-analysisPolymorphismEcologyQH540-549.5GeneticsQH426-470ENGenes and Environment, Vol 43, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Breast Cancer Genetics Meta-analysis Polymorphism Ecology QH540-549.5 Genetics QH426-470
spellingShingle	Breast Cancer Genetics Meta-analysis Polymorphism Ecology QH540-549.5 Genetics QH426-470 Xue Hu Chunguo Cui Tong Sun Wan Wang Associations between ADIPOQ rs2241766 SNP and breast cancer risk: a systematic review and a meta-analysis
description	Abstract Purpose We aimed to conduct a meta-analysis to accurately evaluate the potential association between ADIPOQ rs2241766 gene SNP and breast cancer risk. Methods A systematic literature search on Cochrane Library, PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI) identified 8 articles with 1692 cases and 1890 controls. Strength of association was evaluated by pooled odds ratio (OR), 95 % confidence interval (CI) and p value. Funnel plots and Begger’s regression test were applied for testing the publication bias. Statistical analysis of all data was performed by Stata 12.0. Results The meta-analysis results indicated that the ADIPOQ rs2241766 gene polymorphism did not significantly associated with the risk of breast cancer for these genetic models (TT vs. TG + GG: OR = 1.20, 95 % CI = 0.77–1.89, p=0.417; TT + TG vs. GG: OR = 1.05, 95 % CI = 0.71–1.56, p=0.805; T vs. G: OR =1.17, 95 % CI = 0.79–1.74, p=0.437). Conclusions This study indicated that no significant relationship between the ADIPOQ rs2241766 SNP and breast cancer. Further large-scale and well-designed studies will be indispensable to confirm our result.
format	article
author	Xue Hu Chunguo Cui Tong Sun Wan Wang
author_facet	Xue Hu Chunguo Cui Tong Sun Wan Wang
author_sort	Xue Hu
title	Associations between ADIPOQ rs2241766 SNP and breast cancer risk: a systematic review and a meta-analysis
title_short	Associations between ADIPOQ rs2241766 SNP and breast cancer risk: a systematic review and a meta-analysis
title_full	Associations between ADIPOQ rs2241766 SNP and breast cancer risk: a systematic review and a meta-analysis
title_fullStr	Associations between ADIPOQ rs2241766 SNP and breast cancer risk: a systematic review and a meta-analysis
title_full_unstemmed	Associations between ADIPOQ rs2241766 SNP and breast cancer risk: a systematic review and a meta-analysis
title_sort	associations between adipoq rs2241766 snp and breast cancer risk: a systematic review and a meta-analysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/73b182d1f69a466f8deb07f8ea1c1afa
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Associations between ADIPOQ rs2241766 SNP and breast cancer risk: a systematic review and a meta-analysis

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