Urinary Metabolite Signatures for Predicting Elderly Stroke Survivors with Depression

Jin Chen,1,* Yan-ni Lv,2,* Xiao-bing Li,1,* Jia-jun Xiong,1,* Hui-ting Liang,1 Liang Xie,3 Chen-yi Wan,1 Yun-qing Chen,1 Han-sen Wang,3 Pan Liu,3 He-qing zheng3 1Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of C...

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Autores principales:	Chen J, Lv Y, Li X, Xiong J, Liang H, Xie L, Wan C, Chen Y, Wang H, Liu P, Zheng H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	post-stroke depression metabolomics biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/73b24e2ee705408eb2eb86229f4cc2e4
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spelling	oai:doaj.org-article:73b24e2ee705408eb2eb86229f4cc2e42021-12-02T14:02:58ZUrinary Metabolite Signatures for Predicting Elderly Stroke Survivors with Depression1178-2021https://doaj.org/article/73b24e2ee705408eb2eb86229f4cc2e42021-03-01T00:00:00Zhttps://www.dovepress.com/urinary-metabolite-signatures-for-predicting-elderly-stroke-survivors--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jin Chen,1,* Yan-ni Lv,2,* Xiao-bing Li,1,* Jia-jun Xiong,1,* Hui-ting Liang,1 Liang Xie,3 Chen-yi Wan,1 Yun-qing Chen,1 Han-sen Wang,3 Pan Liu,3 He-qing zheng3 1Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China; 2Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China; 3Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jin ChenDepartment of Neurology, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Road, Nanchang, Jiangxi, 330006, People’s Republic of ChinaEmail jin_chen080706@yeah.netBackground: Post-stroke depression (PSD) is a major complication in stroke survivors, especially in elderly stroke survivors. But there are still no objective methods to diagnose depression in elderly stroke survivors. Thus, this study was conducted to identify potential biomarkers for diagnosing elderly PSD subjects.Methods: Elderly (60 years or older) stroke survivors with depression were assigned into the PSD group, and elderly stroke survivors without depression and elderly healthy controls (HCs) were assigned into the non-depressed group. Urinary metabolite signatures obtained from gas chromatography-mass spectrometry (GC-MS)-based metabolomic platform were collected. Both univariate and multivariate statistical analysis were used to find the differential urinary metabolites between the two groups.Results: The 78 elderly HCs, 122 elderly stroke survivors without depression and 124 elderly PSD subjects were included. A set of 13 differential urinary metabolites responsible for distinguishing PSD subjects from non-depressed subjects were found. The Phenylalanine, tyrosine and tryptophan biosynthesis, Phenylalanine metabolism and Galactose metabolism were found to be significantly changed in elderly PSD subjects. The phenylalanine was significantly negatively correlated with age and depressive symptoms. Meanwhile, a biomarker panel consisting of 3-hydroxyphenylacetic acid, tyrosine, phenylalanine, sucrose, palmitic acid, glyceric acid, azelaic acid and α-aminobutyric acid was identified.Conclusion: These results provided candidate molecules for developing objective methods to diagnose depression in elderly stroke survivors, suggested that taking supplements of phenylalanine might be an effective method to prevent depression in elderly stroke survivors, and would be helpful for future revealing the pathophysiological mechanism of PSD.Keywords: post-stroke depression, metabolomics, biomarkerChen JLv YLi XXiong JLiang HXie LWan CChen YWang HLiu PZheng HDove Medical Pressarticlepost-stroke depressionmetabolomicsbiomarkerNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 925-933 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	post-stroke depression metabolomics biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	post-stroke depression metabolomics biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Chen J Lv Y Li X Xiong J Liang H Xie L Wan C Chen Y Wang H Liu P Zheng H Urinary Metabolite Signatures for Predicting Elderly Stroke Survivors with Depression
description	Jin Chen,1,* Yan-ni Lv,2,* Xiao-bing Li,1,* Jia-jun Xiong,1,* Hui-ting Liang,1 Liang Xie,3 Chen-yi Wan,1 Yun-qing Chen,1 Han-sen Wang,3 Pan Liu,3 He-qing zheng3 1Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China; 2Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China; 3Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jin ChenDepartment of Neurology, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Road, Nanchang, Jiangxi, 330006, People’s Republic of ChinaEmail jin_chen080706@yeah.netBackground: Post-stroke depression (PSD) is a major complication in stroke survivors, especially in elderly stroke survivors. But there are still no objective methods to diagnose depression in elderly stroke survivors. Thus, this study was conducted to identify potential biomarkers for diagnosing elderly PSD subjects.Methods: Elderly (60 years or older) stroke survivors with depression were assigned into the PSD group, and elderly stroke survivors without depression and elderly healthy controls (HCs) were assigned into the non-depressed group. Urinary metabolite signatures obtained from gas chromatography-mass spectrometry (GC-MS)-based metabolomic platform were collected. Both univariate and multivariate statistical analysis were used to find the differential urinary metabolites between the two groups.Results: The 78 elderly HCs, 122 elderly stroke survivors without depression and 124 elderly PSD subjects were included. A set of 13 differential urinary metabolites responsible for distinguishing PSD subjects from non-depressed subjects were found. The Phenylalanine, tyrosine and tryptophan biosynthesis, Phenylalanine metabolism and Galactose metabolism were found to be significantly changed in elderly PSD subjects. The phenylalanine was significantly negatively correlated with age and depressive symptoms. Meanwhile, a biomarker panel consisting of 3-hydroxyphenylacetic acid, tyrosine, phenylalanine, sucrose, palmitic acid, glyceric acid, azelaic acid and α-aminobutyric acid was identified.Conclusion: These results provided candidate molecules for developing objective methods to diagnose depression in elderly stroke survivors, suggested that taking supplements of phenylalanine might be an effective method to prevent depression in elderly stroke survivors, and would be helpful for future revealing the pathophysiological mechanism of PSD.Keywords: post-stroke depression, metabolomics, biomarker
format	article
author	Chen J Lv Y Li X Xiong J Liang H Xie L Wan C Chen Y Wang H Liu P Zheng H
author_facet	Chen J Lv Y Li X Xiong J Liang H Xie L Wan C Chen Y Wang H Liu P Zheng H
author_sort	Chen J
title	Urinary Metabolite Signatures for Predicting Elderly Stroke Survivors with Depression
title_short	Urinary Metabolite Signatures for Predicting Elderly Stroke Survivors with Depression
title_full	Urinary Metabolite Signatures for Predicting Elderly Stroke Survivors with Depression
title_fullStr	Urinary Metabolite Signatures for Predicting Elderly Stroke Survivors with Depression
title_full_unstemmed	Urinary Metabolite Signatures for Predicting Elderly Stroke Survivors with Depression
title_sort	urinary metabolite signatures for predicting elderly stroke survivors with depression
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/73b24e2ee705408eb2eb86229f4cc2e4
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Urinary Metabolite Signatures for Predicting Elderly Stroke Survivors with Depression

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