Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells

The cellular origin and oncogenic drivers promoting claudin-low breast cancer are undefined. Here, the authors report that the consistent activation of oncogenic RAS signaling, as well as regulators of EMT, play a crucial role in the cellular plasticity and maintenance of the mesenchymal and stem ce...

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Autores principales:	Patrick D. Rädler, Barbara L. Wehde, Aleata A. Triplett, Hridaya Shrestha, Jonathan H. Shepherd, Adam D. Pfefferle, Hallgeir Rui, Robert D. Cardiff, Charles M. Perou, Kay-Uwe Wagner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/73b3b931199c4ef2944a84166e09403e
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spelling	oai:doaj.org-article:73b3b931199c4ef2944a84166e09403e2021-12-02T17:24:21ZHighly metastatic claudin-low mammary cancers can originate from luminal epithelial cells10.1038/s41467-021-23957-52041-1723https://doaj.org/article/73b3b931199c4ef2944a84166e09403e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23957-5https://doaj.org/toc/2041-1723The cellular origin and oncogenic drivers promoting claudin-low breast cancer are undefined. Here, the authors report that the consistent activation of oncogenic RAS signaling, as well as regulators of EMT, play a crucial role in the cellular plasticity and maintenance of the mesenchymal and stem cell characteristics of claudin-low mammary cancer cells.Patrick D. RädlerBarbara L. WehdeAleata A. TriplettHridaya ShresthaJonathan H. ShepherdAdam D. PfefferleHallgeir RuiRobert D. CardiffCharles M. PerouKay-Uwe WagnerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patrick D. Rädler Barbara L. Wehde Aleata A. Triplett Hridaya Shrestha Jonathan H. Shepherd Adam D. Pfefferle Hallgeir Rui Robert D. Cardiff Charles M. Perou Kay-Uwe Wagner Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells
description	The cellular origin and oncogenic drivers promoting claudin-low breast cancer are undefined. Here, the authors report that the consistent activation of oncogenic RAS signaling, as well as regulators of EMT, play a crucial role in the cellular plasticity and maintenance of the mesenchymal and stem cell characteristics of claudin-low mammary cancer cells.
format	article
author	Patrick D. Rädler Barbara L. Wehde Aleata A. Triplett Hridaya Shrestha Jonathan H. Shepherd Adam D. Pfefferle Hallgeir Rui Robert D. Cardiff Charles M. Perou Kay-Uwe Wagner
author_facet	Patrick D. Rädler Barbara L. Wehde Aleata A. Triplett Hridaya Shrestha Jonathan H. Shepherd Adam D. Pfefferle Hallgeir Rui Robert D. Cardiff Charles M. Perou Kay-Uwe Wagner
author_sort	Patrick D. Rädler
title	Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells
title_short	Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells
title_full	Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells
title_fullStr	Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells
title_full_unstemmed	Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells
title_sort	highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/73b3b931199c4ef2944a84166e09403e
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Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells

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