Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance
Red blood cells (RBCs) are phagocytosed in the spleen in sickle cell disease and malaria. Here, Cao et al. show that high mannose N-glycans, exposed on diseased or oxidized RBC surfaces, bind mannose receptor CD206 on host cells, mediating phagocytosis.
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Nature Portfolio
2021
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oai:doaj.org-article:73b50900a7f8419f8344f99ed38257e22021-12-02T16:30:42ZRed blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance10.1038/s41467-021-21814-z2041-1723https://doaj.org/article/73b50900a7f8419f8344f99ed38257e22021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21814-zhttps://doaj.org/toc/2041-1723Red blood cells (RBCs) are phagocytosed in the spleen in sickle cell disease and malaria. Here, Cao et al. show that high mannose N-glycans, exposed on diseased or oxidized RBC surfaces, bind mannose receptor CD206 on host cells, mediating phagocytosis.Huan CaoAristotelis AntonopoulosSadie HendersonHeather WassallJohn BrewinAlanna MassonJenna ShepherdGabriela KoniecznyBhinal PatelMaria-Louise WilliamsAdam DavieMegan A. ForresterLindsay HallBeverley MinterDimitris TampakisMichael MossCharlotte LennonWendy PickfordLars ErwigBeverley RobertsonAnne DellGordon D. BrownHeather M. WilsonDavid C. ReesStuart M. HaslamJ. Alexandra RoweRobert N. BarkerMark A. VickersNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Huan Cao Aristotelis Antonopoulos Sadie Henderson Heather Wassall John Brewin Alanna Masson Jenna Shepherd Gabriela Konieczny Bhinal Patel Maria-Louise Williams Adam Davie Megan A. Forrester Lindsay Hall Beverley Minter Dimitris Tampakis Michael Moss Charlotte Lennon Wendy Pickford Lars Erwig Beverley Robertson Anne Dell Gordon D. Brown Heather M. Wilson David C. Rees Stuart M. Haslam J. Alexandra Rowe Robert N. Barker Mark A. Vickers Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance |
| description |
Red blood cells (RBCs) are phagocytosed in the spleen in sickle cell disease and malaria. Here, Cao et al. show that high mannose N-glycans, exposed on diseased or oxidized RBC surfaces, bind mannose receptor CD206 on host cells, mediating phagocytosis. |
| format |
article |
| author |
Huan Cao Aristotelis Antonopoulos Sadie Henderson Heather Wassall John Brewin Alanna Masson Jenna Shepherd Gabriela Konieczny Bhinal Patel Maria-Louise Williams Adam Davie Megan A. Forrester Lindsay Hall Beverley Minter Dimitris Tampakis Michael Moss Charlotte Lennon Wendy Pickford Lars Erwig Beverley Robertson Anne Dell Gordon D. Brown Heather M. Wilson David C. Rees Stuart M. Haslam J. Alexandra Rowe Robert N. Barker Mark A. Vickers |
| author_facet |
Huan Cao Aristotelis Antonopoulos Sadie Henderson Heather Wassall John Brewin Alanna Masson Jenna Shepherd Gabriela Konieczny Bhinal Patel Maria-Louise Williams Adam Davie Megan A. Forrester Lindsay Hall Beverley Minter Dimitris Tampakis Michael Moss Charlotte Lennon Wendy Pickford Lars Erwig Beverley Robertson Anne Dell Gordon D. Brown Heather M. Wilson David C. Rees Stuart M. Haslam J. Alexandra Rowe Robert N. Barker Mark A. Vickers |
| author_sort |
Huan Cao |
| title |
Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance |
| title_short |
Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance |
| title_full |
Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance |
| title_fullStr |
Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance |
| title_full_unstemmed |
Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance |
| title_sort |
red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/73b50900a7f8419f8344f99ed38257e2 |
| work_keys_str_mv |
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