Interoceptive insular cortex participates in sensory processing of gastrointestinal malaise and associated behaviors

Abstract The insular cortex plays a central role in the perception and regulation of bodily needs and emotions. Its modular arrangement, corresponding with different sensory modalities, denotes a complex organization, and reveals it to be a hub that is able to coordinate autonomic and behavioral res...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Marcelo Aguilar-Rivera, Sanggyun Kim, Todd P. Coleman, Pedro E. Maldonado, Fernando Torrealba
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/73b6b7eee38449dca5f97e4e937a1530
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:73b6b7eee38449dca5f97e4e937a1530
record_format	dspace
spelling	oai:doaj.org-article:73b6b7eee38449dca5f97e4e937a15302021-12-02T16:18:07ZInteroceptive insular cortex participates in sensory processing of gastrointestinal malaise and associated behaviors10.1038/s41598-020-78200-w2045-2322https://doaj.org/article/73b6b7eee38449dca5f97e4e937a15302020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78200-whttps://doaj.org/toc/2045-2322Abstract The insular cortex plays a central role in the perception and regulation of bodily needs and emotions. Its modular arrangement, corresponding with different sensory modalities, denotes a complex organization, and reveals it to be a hub that is able to coordinate autonomic and behavioral responses to many types of stimuli. Yet, little is known about the dynamics of its electrical activity at the neuronal level. We recorded single neurons in behaving rats from the posterior insula cortex (pIC), a subdivision considered as a primary interoceptive cortex, during gastrointestinal (GI) malaise, a state akin to the emotion of disgust in humans. We found that a large proportion of pIC neurons were modulated during the rodent compensatory behaviors of lying on belly (LOB) and Pica. Furthermore, we demonstrated that LOB was correlated with low-frequency oscillations in the field potentials and spikes at the theta (8 Hz) band, and that low-frequency electrical microstimulation of pIC elicited LOB and Pica. These findings demonstrate that pIC neurons play a critical role in GI malaise perception, and that the pIC influences the expression of behaviors that alleviate GI malaise. Our model provides an accessible approach at the single cell level to study innate emotional behaviors, currently elusive in humans.Marcelo Aguilar-RiveraSanggyun KimTodd P. ColemanPedro E. MaldonadoFernando TorrealbaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marcelo Aguilar-Rivera Sanggyun Kim Todd P. Coleman Pedro E. Maldonado Fernando Torrealba Interoceptive insular cortex participates in sensory processing of gastrointestinal malaise and associated behaviors
description	Abstract The insular cortex plays a central role in the perception and regulation of bodily needs and emotions. Its modular arrangement, corresponding with different sensory modalities, denotes a complex organization, and reveals it to be a hub that is able to coordinate autonomic and behavioral responses to many types of stimuli. Yet, little is known about the dynamics of its electrical activity at the neuronal level. We recorded single neurons in behaving rats from the posterior insula cortex (pIC), a subdivision considered as a primary interoceptive cortex, during gastrointestinal (GI) malaise, a state akin to the emotion of disgust in humans. We found that a large proportion of pIC neurons were modulated during the rodent compensatory behaviors of lying on belly (LOB) and Pica. Furthermore, we demonstrated that LOB was correlated with low-frequency oscillations in the field potentials and spikes at the theta (8 Hz) band, and that low-frequency electrical microstimulation of pIC elicited LOB and Pica. These findings demonstrate that pIC neurons play a critical role in GI malaise perception, and that the pIC influences the expression of behaviors that alleviate GI malaise. Our model provides an accessible approach at the single cell level to study innate emotional behaviors, currently elusive in humans.
format	article
author	Marcelo Aguilar-Rivera Sanggyun Kim Todd P. Coleman Pedro E. Maldonado Fernando Torrealba
author_facet	Marcelo Aguilar-Rivera Sanggyun Kim Todd P. Coleman Pedro E. Maldonado Fernando Torrealba
author_sort	Marcelo Aguilar-Rivera
title	Interoceptive insular cortex participates in sensory processing of gastrointestinal malaise and associated behaviors
title_short	Interoceptive insular cortex participates in sensory processing of gastrointestinal malaise and associated behaviors
title_full	Interoceptive insular cortex participates in sensory processing of gastrointestinal malaise and associated behaviors
title_fullStr	Interoceptive insular cortex participates in sensory processing of gastrointestinal malaise and associated behaviors
title_full_unstemmed	Interoceptive insular cortex participates in sensory processing of gastrointestinal malaise and associated behaviors
title_sort	interoceptive insular cortex participates in sensory processing of gastrointestinal malaise and associated behaviors
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/73b6b7eee38449dca5f97e4e937a1530
work_keys_str_mv	AT marceloaguilarrivera interoceptiveinsularcortexparticipatesinsensoryprocessingofgastrointestinalmalaiseandassociatedbehaviors AT sanggyunkim interoceptiveinsularcortexparticipatesinsensoryprocessingofgastrointestinalmalaiseandassociatedbehaviors AT toddpcoleman interoceptiveinsularcortexparticipatesinsensoryprocessingofgastrointestinalmalaiseandassociatedbehaviors AT pedroemaldonado interoceptiveinsularcortexparticipatesinsensoryprocessingofgastrointestinalmalaiseandassociatedbehaviors AT fernandotorrealba interoceptiveinsularcortexparticipatesinsensoryprocessingofgastrointestinalmalaiseandassociatedbehaviors
_version_	1718384175314108416

Interoceptive insular cortex participates in sensory processing of gastrointestinal malaise and associated behaviors

Ejemplares similares