Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL

Ibrutinib, a Bruton tyrosine kinase inhibitor, provides effective treatment for chronic lymphocytic leukemia (CLL). Here, the authors describe time-dependent molecular changes to malignant cells and to the immune system in patients undergoing ibrutinib therapy, with can be used for therapy monitorin...

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Autores principales:	André F. Rendeiro, Thomas Krausgruber, Nikolaus Fortelny, Fangwen Zhao, Thomas Penz, Matthias Farlik, Linda C. Schuster, Amelie Nemc, Szabolcs Tasnády, Marienn Réti, Zoltán Mátrai, Donát Alpár, Csaba Bödör, Christian Schmidl, Christoph Bock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/73b869eadff94edea5bfbf6a4cfbce75
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spelling	oai:doaj.org-article:73b869eadff94edea5bfbf6a4cfbce752021-12-02T17:32:59ZChromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL10.1038/s41467-019-14081-62041-1723https://doaj.org/article/73b869eadff94edea5bfbf6a4cfbce752020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14081-6https://doaj.org/toc/2041-1723Ibrutinib, a Bruton tyrosine kinase inhibitor, provides effective treatment for chronic lymphocytic leukemia (CLL). Here, the authors describe time-dependent molecular changes to malignant cells and to the immune system in patients undergoing ibrutinib therapy, with can be used for therapy monitoring.André F. RendeiroThomas KrausgruberNikolaus FortelnyFangwen ZhaoThomas PenzMatthias FarlikLinda C. SchusterAmelie NemcSzabolcs TasnádyMarienn RétiZoltán MátraiDonát AlpárCsaba BödörChristian SchmidlChristoph BockNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q André F. Rendeiro Thomas Krausgruber Nikolaus Fortelny Fangwen Zhao Thomas Penz Matthias Farlik Linda C. Schuster Amelie Nemc Szabolcs Tasnády Marienn Réti Zoltán Mátrai Donát Alpár Csaba Bödör Christian Schmidl Christoph Bock Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL
description	Ibrutinib, a Bruton tyrosine kinase inhibitor, provides effective treatment for chronic lymphocytic leukemia (CLL). Here, the authors describe time-dependent molecular changes to malignant cells and to the immune system in patients undergoing ibrutinib therapy, with can be used for therapy monitoring.
format	article
author	André F. Rendeiro Thomas Krausgruber Nikolaus Fortelny Fangwen Zhao Thomas Penz Matthias Farlik Linda C. Schuster Amelie Nemc Szabolcs Tasnády Marienn Réti Zoltán Mátrai Donát Alpár Csaba Bödör Christian Schmidl Christoph Bock
author_facet	André F. Rendeiro Thomas Krausgruber Nikolaus Fortelny Fangwen Zhao Thomas Penz Matthias Farlik Linda C. Schuster Amelie Nemc Szabolcs Tasnády Marienn Réti Zoltán Mátrai Donát Alpár Csaba Bödör Christian Schmidl Christoph Bock
author_sort	André F. Rendeiro
title	Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL
title_short	Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL
title_full	Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL
title_fullStr	Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL
title_full_unstemmed	Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL
title_sort	chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in cll
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/73b869eadff94edea5bfbf6a4cfbce75
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Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL

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