Telomere shortening in patients on long-term hemodialysis

Background: Leukocyte telomere length shortening is a characteristic of premature senescence, a process that can be accelerated by oxidative stress. In general, patients with end-stage renal disease undergoing regular hemodialysis (HD) are repeatedly exposed to oxidative stress. Patients undergoing...

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Autores principales:	Yucheng Wang, Siyu Chen, Shi Feng, Cuili Wang, Hong Jiang, Song Rong, Haller Hermann, Jianghua Chen, Ping Zhang
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2021
Materias:	Telomere length Hemodialysis Chronic kidney disease Cardiovascular disease Hemoglobin Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/73c08ad2fb434e4eb8f53401bdf39b63
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spelling	oai:doaj.org-article:73c08ad2fb434e4eb8f53401bdf39b632021-12-02T18:12:15ZTelomere shortening in patients on long-term hemodialysis2095-882X10.1016/j.cdtm.2021.07.003https://doaj.org/article/73c08ad2fb434e4eb8f53401bdf39b632021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X21000499https://doaj.org/toc/2095-882XBackground: Leukocyte telomere length shortening is a characteristic of premature senescence, a process that can be accelerated by oxidative stress. In general, patients with end-stage renal disease undergoing regular hemodialysis (HD) are repeatedly exposed to oxidative stress. Patients undergoing HD tend to have cardiovascular diseases associated with oxidative stress and inflammation. Therefore, we assumed that telomere length is associated with HD vintage and the degree of vascular calcification. Methods: A total of 144 patients undergoing regular HD before kidney transplantation and 62 patients on hemodialysis, but not undergoing kidney transplantation, were enrolled. We measured common laboratory values, such as calcium, phosphate, and hemoglobin levels, and assessed the degree of vascular calcification in the patients. The leukocyte telomere length was measured using reverse transcription polymerase chain reaction, and Spearman correlation was used for correlation analysis. Results: The leukocyte telomere length was negatively associated with age (rho = −0.306, P＜0.01); it was shorter in middle-aged patients than in young patients (13.48 ± 4.80 vs. 15.86 ± 4.51, P < 0.01). The telomere length was significantly different among patients aged 52–74 years in groups with different HD vintages. Additionally, the telomere length was positively associated with serum hemoglobin (Hb) levels in all patients (rho = 0.290, P < 0.01). There was a significant difference among patients divided into three groups according to the degree of anemia (17.09 ± 5.64 vs. 14.40 ± 4.07 vs. 13.99 ± 3.95, P < 0.01). Further, a significant difference was observed in the telomere length among patients with different degrees of vascular calcification (16.79 ± 4.91 vs. 13.61 ± 2.82 vs. 14.62 ± 3.63 vs. 10.71 ± 3.74, P < 0.01). The telomere length was shorter in the patients on hemodialysis who did not receive a kidney transplant than in the surgical patients (8.12 ± 1.83 vs. 14.33 ± 4.63, P < 0.01). Conclusion: This study demonstrated that the telomere length was significantly correlated with HD vintage in patients of a certain age group. The telomere length was shorter in patients on hemodialysis who matched for age and dialysis vintage with kidney transplant patients. It was also associated with vascular calcification and serum Hb levels in all patients undergoing HD.Yucheng WangSiyu ChenShi FengCuili WangHong JiangSong RongHaller HermannJianghua ChenPing ZhangKeAi Communications Co., Ltd.articleTelomere lengthHemodialysisChronic kidney diseaseCardiovascular diseaseHemoglobinMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 7, Iss 4, Pp 266-275 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Telomere length Hemodialysis Chronic kidney disease Cardiovascular disease Hemoglobin Medicine (General) R5-920
spellingShingle	Telomere length Hemodialysis Chronic kidney disease Cardiovascular disease Hemoglobin Medicine (General) R5-920 Yucheng Wang Siyu Chen Shi Feng Cuili Wang Hong Jiang Song Rong Haller Hermann Jianghua Chen Ping Zhang Telomere shortening in patients on long-term hemodialysis
description	Background: Leukocyte telomere length shortening is a characteristic of premature senescence, a process that can be accelerated by oxidative stress. In general, patients with end-stage renal disease undergoing regular hemodialysis (HD) are repeatedly exposed to oxidative stress. Patients undergoing HD tend to have cardiovascular diseases associated with oxidative stress and inflammation. Therefore, we assumed that telomere length is associated with HD vintage and the degree of vascular calcification. Methods: A total of 144 patients undergoing regular HD before kidney transplantation and 62 patients on hemodialysis, but not undergoing kidney transplantation, were enrolled. We measured common laboratory values, such as calcium, phosphate, and hemoglobin levels, and assessed the degree of vascular calcification in the patients. The leukocyte telomere length was measured using reverse transcription polymerase chain reaction, and Spearman correlation was used for correlation analysis. Results: The leukocyte telomere length was negatively associated with age (rho = −0.306, P＜0.01); it was shorter in middle-aged patients than in young patients (13.48 ± 4.80 vs. 15.86 ± 4.51, P < 0.01). The telomere length was significantly different among patients aged 52–74 years in groups with different HD vintages. Additionally, the telomere length was positively associated with serum hemoglobin (Hb) levels in all patients (rho = 0.290, P < 0.01). There was a significant difference among patients divided into three groups according to the degree of anemia (17.09 ± 5.64 vs. 14.40 ± 4.07 vs. 13.99 ± 3.95, P < 0.01). Further, a significant difference was observed in the telomere length among patients with different degrees of vascular calcification (16.79 ± 4.91 vs. 13.61 ± 2.82 vs. 14.62 ± 3.63 vs. 10.71 ± 3.74, P < 0.01). The telomere length was shorter in the patients on hemodialysis who did not receive a kidney transplant than in the surgical patients (8.12 ± 1.83 vs. 14.33 ± 4.63, P < 0.01). Conclusion: This study demonstrated that the telomere length was significantly correlated with HD vintage in patients of a certain age group. The telomere length was shorter in patients on hemodialysis who matched for age and dialysis vintage with kidney transplant patients. It was also associated with vascular calcification and serum Hb levels in all patients undergoing HD.
format	article
author	Yucheng Wang Siyu Chen Shi Feng Cuili Wang Hong Jiang Song Rong Haller Hermann Jianghua Chen Ping Zhang
author_facet	Yucheng Wang Siyu Chen Shi Feng Cuili Wang Hong Jiang Song Rong Haller Hermann Jianghua Chen Ping Zhang
author_sort	Yucheng Wang
title	Telomere shortening in patients on long-term hemodialysis
title_short	Telomere shortening in patients on long-term hemodialysis
title_full	Telomere shortening in patients on long-term hemodialysis
title_fullStr	Telomere shortening in patients on long-term hemodialysis
title_full_unstemmed	Telomere shortening in patients on long-term hemodialysis
title_sort	telomere shortening in patients on long-term hemodialysis
publisher	KeAi Communications Co., Ltd.
publishDate	2021
url	https://doaj.org/article/73c08ad2fb434e4eb8f53401bdf39b63
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Telomere shortening in patients on long-term hemodialysis

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