Maternal pre-pregnancy BMI associates with neonate local and distal functional connectivity of the left superior frontal gyrus

Abstract Maternal obesity/overweight during pregnancy has reached epidemic proportions and has been linked with adverse outcomes for the offspring, including cognitive impairment and increased risk for neuropsychiatric disorders. Prior neuroimaging investigations have reported widespread aberrant fu...

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Autores principales:	Olli Rajasilta, Suvi Häkkinen, Malin Björnsdotter, Noora M. Scheinin, Satu J. Lehtola, Jani Saunavaara, Riitta Parkkola, Tuire Lähdesmäki, Linnea Karlsson, Hasse Karlsson, Jetro J. Tuulari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/73c0e07b3b3f421a9d4c99cc3d813f64
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spelling	oai:doaj.org-article:73c0e07b3b3f421a9d4c99cc3d813f642021-12-02T19:16:59ZMaternal pre-pregnancy BMI associates with neonate local and distal functional connectivity of the left superior frontal gyrus10.1038/s41598-021-98574-92045-2322https://doaj.org/article/73c0e07b3b3f421a9d4c99cc3d813f642021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98574-9https://doaj.org/toc/2045-2322Abstract Maternal obesity/overweight during pregnancy has reached epidemic proportions and has been linked with adverse outcomes for the offspring, including cognitive impairment and increased risk for neuropsychiatric disorders. Prior neuroimaging investigations have reported widespread aberrant functional connectivity and white matter tract abnormalities in neonates born to obese mothers. Here we explored whether maternal pre-pregnancy adiposity is associated with alterations in local neuronal synchrony and distal connectivity in the neonate brain. 21 healthy mother-neonate dyads from uncomplicated pregnancies were included in this study (age at scanning 26.14 ± 6.28 days, 12 male). The neonates were scanned with a 6-min resting-state functional magnetic resonance imaging (rs-fMRI) during natural sleep. Regional homogeneity (ReHo) maps were computed from obtained rs-fMRI data. Multiple regression analysis was performed to assess the association of pre-pregnancy maternal body-mass-index (BMI) and ReHo. Seed-based connectivity analysis with multiple regression was subsequently performed with seed-ROI derived from ReHo analysis. Maternal adiposity measured by pre-pregnancy BMI was positively associated with neonate ReHo values within the left superior frontal gyrus (SFG) (FWE-corrected p < 0.005). Additionally, we found both positive and negative associations (p < 0.05, FWE-corrected) for maternal pre-pregnancy BMI and seed-based connectivity between left SFG and prefrontal, amygdalae, basal ganglia and insular regions. Our results imply that maternal pre-pregnancy BMI associates with local and distal functional connectivity within the neonate left superior frontal gyrus. These findings add to the evidence that increased maternal pre-pregnancy BMI has a programming influence on the developing neonate brain functional networks.Olli RajasiltaSuvi HäkkinenMalin BjörnsdotterNoora M. ScheininSatu J. LehtolaJani SaunavaaraRiitta ParkkolaTuire LähdesmäkiLinnea KarlssonHasse KarlssonJetro J. TuulariNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Olli Rajasilta Suvi Häkkinen Malin Björnsdotter Noora M. Scheinin Satu J. Lehtola Jani Saunavaara Riitta Parkkola Tuire Lähdesmäki Linnea Karlsson Hasse Karlsson Jetro J. Tuulari Maternal pre-pregnancy BMI associates with neonate local and distal functional connectivity of the left superior frontal gyrus
description	Abstract Maternal obesity/overweight during pregnancy has reached epidemic proportions and has been linked with adverse outcomes for the offspring, including cognitive impairment and increased risk for neuropsychiatric disorders. Prior neuroimaging investigations have reported widespread aberrant functional connectivity and white matter tract abnormalities in neonates born to obese mothers. Here we explored whether maternal pre-pregnancy adiposity is associated with alterations in local neuronal synchrony and distal connectivity in the neonate brain. 21 healthy mother-neonate dyads from uncomplicated pregnancies were included in this study (age at scanning 26.14 ± 6.28 days, 12 male). The neonates were scanned with a 6-min resting-state functional magnetic resonance imaging (rs-fMRI) during natural sleep. Regional homogeneity (ReHo) maps were computed from obtained rs-fMRI data. Multiple regression analysis was performed to assess the association of pre-pregnancy maternal body-mass-index (BMI) and ReHo. Seed-based connectivity analysis with multiple regression was subsequently performed with seed-ROI derived from ReHo analysis. Maternal adiposity measured by pre-pregnancy BMI was positively associated with neonate ReHo values within the left superior frontal gyrus (SFG) (FWE-corrected p < 0.005). Additionally, we found both positive and negative associations (p < 0.05, FWE-corrected) for maternal pre-pregnancy BMI and seed-based connectivity between left SFG and prefrontal, amygdalae, basal ganglia and insular regions. Our results imply that maternal pre-pregnancy BMI associates with local and distal functional connectivity within the neonate left superior frontal gyrus. These findings add to the evidence that increased maternal pre-pregnancy BMI has a programming influence on the developing neonate brain functional networks.
format	article
author	Olli Rajasilta Suvi Häkkinen Malin Björnsdotter Noora M. Scheinin Satu J. Lehtola Jani Saunavaara Riitta Parkkola Tuire Lähdesmäki Linnea Karlsson Hasse Karlsson Jetro J. Tuulari
author_facet	Olli Rajasilta Suvi Häkkinen Malin Björnsdotter Noora M. Scheinin Satu J. Lehtola Jani Saunavaara Riitta Parkkola Tuire Lähdesmäki Linnea Karlsson Hasse Karlsson Jetro J. Tuulari
author_sort	Olli Rajasilta
title	Maternal pre-pregnancy BMI associates with neonate local and distal functional connectivity of the left superior frontal gyrus
title_short	Maternal pre-pregnancy BMI associates with neonate local and distal functional connectivity of the left superior frontal gyrus
title_full	Maternal pre-pregnancy BMI associates with neonate local and distal functional connectivity of the left superior frontal gyrus
title_fullStr	Maternal pre-pregnancy BMI associates with neonate local and distal functional connectivity of the left superior frontal gyrus
title_full_unstemmed	Maternal pre-pregnancy BMI associates with neonate local and distal functional connectivity of the left superior frontal gyrus
title_sort	maternal pre-pregnancy bmi associates with neonate local and distal functional connectivity of the left superior frontal gyrus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/73c0e07b3b3f421a9d4c99cc3d813f64
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Maternal pre-pregnancy BMI associates with neonate local and distal functional connectivity of the left superior frontal gyrus

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