Insights into Hunter syndrome from the structure of iduronate-2-sulfatase

Hunter syndrome is a lysosomal storage disease caused by mutations in the enzyme iduronate-2-sulfatase (IDS). Here, the authors present the IDS crystal structure and give mechanistic insights into mutations that cause Hunter syndrome.

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Autores principales:	Mykhaylo Demydchuk, Chris H. Hill, Aiwu Zhou, Gábor Bunkóczi, Penelope E. Stein, Denis Marchesan, Janet E. Deane, Randy J. Read
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/73c38b90598b4907b8cedce5ff4f26cb
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spelling	oai:doaj.org-article:73c38b90598b4907b8cedce5ff4f26cb2021-12-02T14:40:22ZInsights into Hunter syndrome from the structure of iduronate-2-sulfatase10.1038/ncomms157862041-1723https://doaj.org/article/73c38b90598b4907b8cedce5ff4f26cb2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15786https://doaj.org/toc/2041-1723Hunter syndrome is a lysosomal storage disease caused by mutations in the enzyme iduronate-2-sulfatase (IDS). Here, the authors present the IDS crystal structure and give mechanistic insights into mutations that cause Hunter syndrome.Mykhaylo DemydchukChris H. HillAiwu ZhouGábor BunkócziPenelope E. SteinDenis MarchesanJanet E. DeaneRandy J. ReadNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mykhaylo Demydchuk Chris H. Hill Aiwu Zhou Gábor Bunkóczi Penelope E. Stein Denis Marchesan Janet E. Deane Randy J. Read Insights into Hunter syndrome from the structure of iduronate-2-sulfatase
description	Hunter syndrome is a lysosomal storage disease caused by mutations in the enzyme iduronate-2-sulfatase (IDS). Here, the authors present the IDS crystal structure and give mechanistic insights into mutations that cause Hunter syndrome.
format	article
author	Mykhaylo Demydchuk Chris H. Hill Aiwu Zhou Gábor Bunkóczi Penelope E. Stein Denis Marchesan Janet E. Deane Randy J. Read
author_facet	Mykhaylo Demydchuk Chris H. Hill Aiwu Zhou Gábor Bunkóczi Penelope E. Stein Denis Marchesan Janet E. Deane Randy J. Read
author_sort	Mykhaylo Demydchuk
title	Insights into Hunter syndrome from the structure of iduronate-2-sulfatase
title_short	Insights into Hunter syndrome from the structure of iduronate-2-sulfatase
title_full	Insights into Hunter syndrome from the structure of iduronate-2-sulfatase
title_fullStr	Insights into Hunter syndrome from the structure of iduronate-2-sulfatase
title_full_unstemmed	Insights into Hunter syndrome from the structure of iduronate-2-sulfatase
title_sort	insights into hunter syndrome from the structure of iduronate-2-sulfatase
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/73c38b90598b4907b8cedce5ff4f26cb
work_keys_str_mv	AT mykhaylodemydchuk insightsintohuntersyndromefromthestructureofiduronate2sulfatase AT chrishhill insightsintohuntersyndromefromthestructureofiduronate2sulfatase AT aiwuzhou insightsintohuntersyndromefromthestructureofiduronate2sulfatase AT gaborbunkoczi insightsintohuntersyndromefromthestructureofiduronate2sulfatase AT penelopeestein insightsintohuntersyndromefromthestructureofiduronate2sulfatase AT denismarchesan insightsintohuntersyndromefromthestructureofiduronate2sulfatase AT janetedeane insightsintohuntersyndromefromthestructureofiduronate2sulfatase AT randyjread insightsintohuntersyndromefromthestructureofiduronate2sulfatase
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Insights into Hunter syndrome from the structure of iduronate-2-sulfatase

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